DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and AREL1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	1052	Identity:	206/1052 - (19%)
Similarity:	348/1052 - (33%)	Gaps:	354/1052 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2140 PFEVNHSGLIKAMLNYMTSETGLVERDARLR-SFMHVFAGLPLEPLLQNVGQMP--TIEPIAF-- 2199
            |:||.||...:..|.|...:.....|...|| ...||...:.: |:.|.|.|.|  .:..:||
Human    69 PYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEI-PVTQEVLQEPNSNVVKVAFTV 132

  Fly  2200 ---GAF--VAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLKC----NLQRHPQ-- 2253
               |.:  ..||.|.......: .|:  |..|....|....:..|:|..|.|    .||..|:
Human   133 RKAGRYEITVKLGGLNVAYSPY-YKI--FQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDE 194

  Fly  2254 ----CNN---LRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVA---AVV 2308
                .||   ||.....|:.|..|.                        .:|:....|:   :|.
Human   195 YDNPTNNSMSLRDEHNYTLSIHELG------------------------PQEEESTGVSFEKSVT 235

  Fly  2309 LSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYR 2373
            .::.:|:..|:.|:......:....||          .||..:.|.:.::    :...:..|
Human   236 SNRQTFQVFLRLTLHSRGCFHACISYQ----------NQPINNGEFDIIV----LSEDEKNI--- 283

  Fly  2374 PVEEEV-TSGAA---AGAASSSSSCSS-----GVQKQQSSSSSASSCVNATSSCSSSSGVASGGG 2429
             ||..| |||.:   .....::::|||     ......||....|:.|:.....|.|
Human   284 -VERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPS-------- 339

  Fly  2430 SLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHAL 2494
                :.|........||...:   ::|...| :|.|....:|..:.|.:
Human   340 ----ECHTPEKVKKPKKVYCY---VSPKQFS-VKEFYLKIIPWRLYTFR---------------- 380

  Fly  2495 NRHWDHLYGCVVRQNIIPQSDF-------IHPKIMAKANRQLQDPLVIMTGNLPQWLPQIGMACP 2552
                           :.|.:.|       :|..:....:..:|              |.:.::|
Human   381 ---------------VCPGTKFSYLGPDPVHKLLTLVVDDGIQ--------------PPVELSC- 415

  Fly  2553 FLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQAEHI 2617
                 :.|::|  |.:|  .|:|.:      ::..:|:.:.......|..|.:          |:
Human   416 -----KERNIL--AATF--IRSLHK------NIGGSETFQDKVNFFQRELRQV----------HM 455

  Fly  2618 LQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKAN 2682
            .:.  |||..|::..              :||:.:.|:.|             .:.:|.|..|..
Human   456 KRP--HSKVTLKVSR--------------HALLESSLKAT-------------RNFSISDWSKNF 491

  Fly  2683 SAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPV 2747
            ..|...|:||     |...|......|:..:...||..
Human   492 EVVFQDEEAL-----DWGGPRREWFELICKALFDTTNQ--------------------------- 524

  Fly  2748 EHSSSSAGANENALNMVIAQQFSDTNSA--NPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTT 2810
                             :..:|||.|.|  :|    ||                 |.........
Human   525 -----------------LFTRFSDNNQALVHP----NP-----------------NRPAHLRLKM 551

  Fly  2811 TSYVHAVHG--LFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSE 2873
            ..:...:.|  |:...||.:.|  |:.:|    :|...|:|: ::..||        .|::..::
Human   552 YEFAGRLVGKCLYESSLGGAYK--QLVRA----RFTRSFLAQ-IIGLRM--------HYKYFETD 601

  Fly  2874 EHSIGLADLMRVAPEVQNTLV--RLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLGL 2936
            :            ||...:.|  .|.:.:.:.|.:.::      ||..|..|||
Human   602 D------------PEFYKSKVCFILNNDMSEMELVFAE------EKYNKSGQLD----------- 637

  Fly  2937 DFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMF 3001
                   ..:||..||..||||..|...|::|:..:.|...|:::.|...:|.:.:.|...|.:|
Human   638 -------KVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIF 695

  Fly  3002 YPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH------GFHQDSQAIQYLYEILASYNRDEQR 3060
            ...|||.:.||:|.           :..|....|      .:|...:.:::.:.:::|..::|..
Human   696 DENELELLMCGTGD-----------ISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELA 749

  Fly  3061 AFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQK 3125
            ..|||.|||.:||.|||.||.|...|:...      .:..||:..||.|.|.||.|.|.|.:.:.
Human   750 RLLQFTTGSSQLPPGGFAALCPSFQIIAAP------THSTLPTAHTCFNQLCLPTYDSYEEVHRM 808

  Fly  3126 LKVAANEGSMSF 3137
            |::|.:||...|
Human   809 LQLAISEGCEGF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	84/330 (25%)
AREL1	NP_001034568.1	Filamin	52..158		24/92 (26%)
		Filamin	56..154	CDD:395505	23/85 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		7/41 (17%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		91/443 (21%)
		HECTc	486..820	CDD:214523	103/471 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900