DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and UBE3C

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_055486.2	Gene:	UBE3C / 9690	HGNCID:	16803	Length:	1083	Species:	Homo sapiens

Alignment Length:	1328	Identity:	250/1328 - (18%)
Similarity:	423/1328 - (31%)	Gaps:	490/1328 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  2032 SISHANLLAAANRERARQWVREQAV--DFVKRYTEQEAKRS--KAASESGATQSGSSGVGLSSTG 2092
            |:.|........||..|:.::...:  .|::.|.:::.:.|  ::|.:..||.|.|.|.
Human    27 SLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQQYSIQRSAFDRCATLSQSGGA------ 85

  Fly  2093 NTPLSTAGSTNVLERL------------------------SSILFK-LNGSYHDCLDALLELKTI 2132
             .|::...:..:|.|.                        ||:..| |:||  :.|..|.::|.:
Human    86 -FPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQNLIKHSSLFVKQLDGS--ERLTCLFQIKRL 147

  Fly  2133 L-----LESDISPFEVNHSGLIKAMLNYMTSETGL--VERDAR-----LRSFMHV---------- 2175
            :     |..:.:...:| ..|...||...:||...  |.:||.     :...:|.
Human   148 MSLCCRLLQNCNDDSLN-VALPMRMLEVFSSENTYLPVLQDASYVVSVIEQILHYMIHNGYYRSL 211

  Fly  2176 -------------FAGLPLEP----LLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQ--FPVKVH 2221
                         ::.|...|    ||:||     ::|:.|     ..|.|.....|  |.....
Human   212 YLLINSKLPSSIEYSDLSRVPIAKILLENV-----LKPLHF-----TYNSCPEGARQQVFTAFTE 266

  Fly  2222 DFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYG 2286
            :|.|.|   .......|.                           |..||..|.:..|
Human   267 EFLAAP---FTDQIFHFI---------------------------IPALADAQTVFPY------- 294

  Fly  2287 GIRADSDDDSEEDMDDNVAAVVLSQASFRHK---------LQFTIGDHVL----PYNMTVYQAVK 2338
                          :..:.|::|.::....|         ...|:|::.|    ...:.||..|.
Human   295 --------------EPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVL 345

  Fly  2339 QFSPLVSEQP-----------ETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSS 2392
            |  ..:|:.|           .:|:|.|:                   ||.....:......|.|
Human   346 Q--TFLSQLPVSPASASCHDSASDSEEES-------------------EEADKPSSPEDGRLSVS 389

  Fly  2393 SCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKK---AHKS-------------SSK 2441
            ..:....|:..:....::.:|.....|:|..|.:...|:...   .|:.             :::
Human   390 YITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNAR 454

  Fly  2442 FMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVV 2506
            |:|   .||              ||.||:...::|..        |:.::..::|      |..:
Human   455 FLR---HLW--------------FLISSMSTRMITGS--------MVPLLQVISR------GSPM 488

  Fly  2507 ----RQNIIP-----QSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHL 2562
                ...|||     .|.|.|..|....|....||:.:           :|.....:.||....|
Human   489 SFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEV-----------VGQRQSSMMPFTLEEL 542

  Fly  2563 LFYATSFDRDRALQRLL----DTTPD-----------LNAAESSE----------------RVAP 2596
            :..:... ||..|..:.    :|.|:           :....|||                :|..
Human   543 IMLSRCL-RDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVIT 606

  Fly  2597 RL-------DRRKRAISRTEILKQAEHILQD---------------------FGHSKALLEIQYE 2633
            .|       |.|:........|.:.|.|..|                     .|..::.|::..|
Human   607 NLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLE 671

  Fly  2634 NEVGTGLGPTLE-------------------------FYALVSAELQRTDLGLWNGSDSYKQNSV 2673
            :       |.|.                         |..|:.|:.|..            |...
Human   672 S-------PPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEV------------QGDG 717

  Fly  2674 TIVDVVKANSAVLHI-EDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHV 2737
            ..:|.:.......:| |||.     |:.:|                     ...|..:...|.|:
Human   718 PFLDGINVTIRRNYIYEDAY-----DKLSP---------------------ENEPDLKKRIRVHL 756

  Fly  2738 LRSGAGQQPVEHSSSSAGAN-----ENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNT 2797
            |.:        |....||.:     ...||.::...|            ||:.....||
Human   757 LNA--------HGLDEAGIDGGGIFREFLNELLKSGF------------NPNQGFFKTT------ 795

  Fly  2798 TTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKA---KFKFLGKFMAKAVMDSRMLD 2859
               |..:               |:|.|..      ||....:   .:.|||:.:.||:.::.:::
Human   796 ---NEGL---------------LYPNPAA------QMLVGDSFARHYYFLGRMLGKALYENMLVE 836

  Fly  2860 LPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQL 2924
            |||:..|...|:.....:.:..|..:.|||...|:.|                       |..:.
Human   837 LPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFL-----------------------KSYED 878

  Fly  2925 DLDGCPIADLGLDFVLP----GHAN-IELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEA 2984
            |::     :|||:|.:.    |.|. :||..||:|.|||..|...||.||..:.|...:::...|
Human   879 DVE-----ELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLA 938

  Fly  2985 LREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH--GFHQDSQAIQYL 3047
            .|:|..:|..::.||||..:|::.:.  ||::...|..::|..     |::  |:..|...|:..
Human   939 FRQGLANVVSLEWLRMFDQQEIQVLI--SGAQVPISLEDLKSF-----TNYSGGYSADHPVIKVF 996

  Fly  3048 YEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLK 3112
            :.::..:..:|:|..|:|||...|.|..|||.|.|...|.....|..:     ||:..||:|.||
Human   997 WRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLER-----LPTASTCMNLLK 1056

  Fly  3113 LPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            ||::....::|.|| :.|.|.:..|.||
Human  1057 LPEFYDETLLRSKL-LYAIECAAGFELS 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	8/45 (18%)
		HECTc	<2818..3138	CDD:294058	89/329 (27%)
UBE3C	NP_055486.2	Cis-determinant of acceptor ubiquitin-binding	1..60		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		2/12 (17%)
		IQ	47..64	CDD:197470	2/16 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..385		5/48 (10%)
		HECTc	725..1081	CDD:238033	110/472 (23%)
		HECTc	747..1080	CDD:214523	103/423 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900