DRSC/TRiP Functional Genomics Resources

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Protein Alignment ctrip and MAGI1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:NP_001028229.1 Gene:MAGI1 / 9223 HGNCID:946 Length:1462 Species:Homo sapiens


Alignment Length:1618 Identity:277/1618 - (17%)
Similarity:473/1618 - (29%) Gaps:586/1618 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   586 VATTTPHALTPQQHQQQRQPPQPPSHQQQQ----VHQQQQPPQLLPTHQFAHLSSFVTPTAAAAA 646
            :.|...|:|  |...:|..|.:..|:...|    ||.:.:....:|...    |||...:.    
Human   202 ITTDALHSL--QSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMN----SSFTADSG---- 256

  Fly   647 AAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTGA 711
                                        .|::|..|..|..|  .:||:..              
Human   257 ----------------------------EQEEHTLQETALPP--VNSSIIA-------------- 277

  Fly   712 GPPPALFQQQAPPQLTRYTPATATTAATFVP-PQQQQVVYNPQQQ----QHSSLRRSSRGKTGSC 771
              .|.....|..||   |.|.:|..  ...| |:..::.|....:    .|::       ||.|.
Human   278 --APITDPSQKFPQ---YLPLSAED--NLGPLPENWEMAYTENGEVYFIDHNT-------KTTSW 328

  Fly   772 VSSAAAAQQQQH----------HQQQQHSSAAAAVQQQLLPPP--GTYQYQQVGGNT----VVVA 820
            :......:||:.          |.::..|........:.:..|  |.|....:...|    .|:.
Human   329 LDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLE 393

  Fly   821 VRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQHQQQQRATLVQPGFLFSYRSNQPQQQ 885
            .:.::||:||||||         ||||.||||||.||.:...:..:.||.|..     .|.|...
Human   394 AKRKKQLEQQQQQQ---------QQQQQQQQQQQQQQTEEWTEDHSALVPPVI-----PNHPPSN 444

  Fly   886 QQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPPHAGGQQITPGANSANLSIVAAAL-SAAR 949
            .:||:::                        |..|.|.     .|...:......:...| .::|
Human   445 PEPAREV------------------------PLQGKPF-----FTRNPSELKGKFIHTKLRKSSR 480

  Fly   950 DVG----GGS-------------DGGGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASS 997
            ..|    ||.             ||..:..|.. .||....||.:|..:|.:.:......|:...
Human   481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKM-ETGDVIVSVNDTCVLGHTHAQVVKIFQSIPI 544

  Fly   998 NSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSE--------------SDDSEVGRL 1048
            .::.......|......|....|:..|       :.|.:|.|              |..|:.|::
Human   545 GASVDLELCRGYPLPFDPDDPNTSLVT-------SVAILDKEPIIVNGQETYDSPASHSSKTGKV 602

  Fly  1049 QALLEARGLPPHLFGALGPRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLV- 1112
            ..:.:||...|              .....|||....|          ::..|.::|.....|: 
Human   603 NGMKDARPSSP--------------ADVASNSSHGYPN----------DTVSLASSIATQPELIT 643

  Fly  1113 -------MGNEDTLAGFP------IKQVVPALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGT 1164
                   ||...|:|..|      :||:|.               :..||.|        :....
Human   644 VHIVKGPMGFGFTIADSPGGGGQRVKQIVD---------------SPRCRGL--------KEGDL 685

  Fly  1165 VVEAVPVFLEKLQVIQCMDVAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALA 1229
            :||.....::.|...|.:|:..:.....|:                         :::.||..|.
Human   686 IVEVNKKNVQALTHNQVVDMLVECPKGSEV-------------------------TLLVQRGGLP 725

  Fly  1230 IAANCCLNMHPEEFHFVAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQH--DGQRLQQIASP 1292
            :         |::   ..:|.|     |.::|.:             .|.||  ...|....|||
Human   726 V---------PKK---SPKSQP-----LERKDSQ-------------NSSQHSVSSHRSLHTASP 760

  Fly  1293 DLLKNCQQLLLVTPAILNTGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAA 1357
            .  .:.|.|....||.                 ...||...|              :|..:|   
Human   761 S--HSTQVLPEFPPAE-----------------AQAPDQTDS--------------SGQKKP--- 789

  Fly  1358 SATHVELISRSPSELYELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHN 1422
            ....:...|||   :||         .|||                :.|:|..:.||.:.|....
Human   790 DPFKIWAQSRS---MYE---------NRLP----------------DYQEQDIFLWRKETGFGFR 826

  Fly  1423 Y--------------------STIDSRLIEAANQSSEDEI----SLSTFGRTYTVDFHAMQQINE 1463
            .                    :..|.||      .|.||:    .....|:::.:....|||..:
Human   827 ILGGNEPGEPIYIGHIVPLGAADTDGRL------RSGDELICVDGTPVIGKSHQLVVQLMQQAAK 885

  Fly  1464 DTGTTRPVQRRL-----------------NHNYVAPMSAGQDLTT-----TSAGSAAAGGASTSA 1506
            .......|:|::                 :|:...|.|..::..|     .|..:.::|..|||.
Human   886 QGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950

  Fly  1507 AAAAASSNNNNNNNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSS 1571
            ..:...            |.|..::.|.:...::.|..   |..|..       |.::..|....
Human   951 IGSGGG------------GGSGVVSTVVQPYDVEIRRG---ENEGFG-------FVIVSSVSRPE 993

  Fly  1572 AGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQLP 1636
            ||......|:         |.|..:.::::..  .:...|.|...| ||:  |:....|..:...
Human   994 AGTTFGNACV---------AMPHKIGRIIEGS--PADRCGKLKVGD-RIL--AVNGCSITNKSHS 1044

  Fly  1637 DVFGTHFRREG--VIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPF 1699
            |:... .:..|  |..:.....:.:|......:.|..:.|.|.|.:..|:|....:....|.:.|
Human  1045 DIVNL-IKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQF 1108

  Fly  1700 FMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALD----------------- 1747
            ...:          |.:::.|.:..............|.:|.....:|                 
Human  1109 EFKA----------PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGK 1163

  Fly  1748 --------ATSSSTTA-------------GG----------------YNYSSSAPSSSSGAPAAY 1775
                    ..:..||.             ||                |:.||.....::|.....
Human  1164 MRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVP 1228

  Fly  1776 FVTQQGDPRQYVHFQQPAVPA--PPPQQELLPSGVQQQGQQVP----QVIYQP--HH-------- 1824
            .|....|.||:     |::.:  ||...:..|.|.::...:.|    :...||  ||        
Human  1229 EVRAGPDRRQH-----PSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRK 1288

  Fly  1825 ---------------QQPAHLVLASTSSGAASSSSSSSSSSSASA---LQHKMTDMLKRKAPPKR 1871
                           ::.|....|:.::|....|.......:.||   |:.:.....:|...|:|
Human  1289 PDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPER 1353

  Fly  1872 KSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSS 1936
            :.:   |:.:|:.|.:            ||....::..||.:          |.:|....| ||.
Human  1354 RRE---RSPTRRRDGS------------PSRRRRSLERLLEQ----------RRSPERRRG-GSP 1392

  Fly  1937 KSRFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSN 1994
            :.|..:.:...|.|.:.....||:  :..|:...:|.      :::...|.:|:|.|:
Human  1393 ERRAKSTDRRRARSPERRRERSLD--KRNREDRASHR------EREEANLKQDAGRSS 1442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669 8/42 (19%)
WWE 1409..1481 CDD:128922 16/112 (14%)
FAM199X <1985..2074 CDD:292442 4/10 (40%)
HECTc <2818..3138 CDD:294058
MAGI1NP_001028229.1 PDZ_signaling 15..100 CDD:238492
GuKc 122..293 CDD:214504 26/149 (17%)
WW 303..332 CDD:238122 6/35 (17%)
WW 361..390 CDD:278809 4/28 (14%)
PDZ 469..555 CDD:214570 15/86 (17%)
PDZ 640..723 CDD:214570 20/130 (15%)
MAGI_u5 722..805 CDD:293271 27/160 (17%)
PDZ_signaling 819..894 CDD:238492 11/80 (14%)
PDZ_signaling 968..1062 CDD:238492 20/118 (17%)
PDZ 1123..1205 CDD:214570 7/81 (9%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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