DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and UBE3B

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_569733.2	Gene:	UBE3B / 89910	HGNCID:	13478	Length:	1068	Species:	Homo sapiens

Alignment Length:	930	Identity:	207/930 - (22%)
Similarity:	347/930 - (37%)	Gaps:	246/930 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2326 VLPYNMTVYQA---VKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHY-----RPVEEEVTSG 2382
            |.|..:||.::   :::|...:.:|....:..|:|.|..::.:..:.:|.     |.:||| |.|
Human   270 VTPERLTVLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEE-TDG 333

  Fly  2383 AAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAH----------- 2436
            ..:....:...|...|.:::|:.:.....:...|. |...|:......:||:..
Human   334 FVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQ-SVDYGLNESMHLITKQLQFLWGVPLIRIF 397

  Fly  2437 --KSSSKFMRKKTELWH------EGIAPVVISALKPFLSSSLPADVV------TVQDASLDALCM 2487
              ...||.:.:..|..|      :.:.||.....:.|..|:...:::      .|..|.:..:|.
Human   398 FCDILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCN 462

  Fly  2488 LRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTG--NLPQWLPQIGMA 2550
            :               ||:.|..:              ....|..|.|:||  .|...||::...
Human   463 I---------------CVLYQTSL--------------TTLTQIRLQILTGLTYLDDLLPKLWAF 498

  Fly  2551 CPFLFPF---------------ETRHLLFYATSF-DRDRALQRLLDTTPDLNAAESSERVAPRLD 2599
            ...|.|.               |::.||.....| |..|.|..:||   |:...|  |:::.:|
Human   499 ICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILD---DIEVYE--EQISFKL- 557

  Fly  2600 RRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQ--------- 2655
                     |.|......|..|     :.::.::..|....|.|||.:..|...|.
Human   558 ---------EELVTISSFLNSF-----VFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRR 608

  Fly  2656 ---------RTDLG---LWNGSDSYKQNSVTIVD----VVKANSAVLHIEDALEATTTDQNTPAV 2704
                     |.||.   |:...|..::.:..|:.    |:...:.||.....:        |...
Human   609 RFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMV--------TKEK 665

  Fly  2705 AGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQ--QPVEHSSSSAGANENALNMVIAQ 2767
            ....||.:|:.:...|     |...|   ||.:|..|..|  |..:|          |:..||..
Human   666 EKLGLVETSSASPHVT-----HITIR---RSRMLEDGYEQLRQLSQH----------AMKGVIRV 712

  Fly  2768 QFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTT--------TTTSYVHAVHGLFPLP 2824
            :|.:....:.|.||...........:.........::..||        :.|||:|..:    |.
Human   713 KFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENY----LQ 773

  Fly  2825 LGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEV 2889
            |               |:|:||.:.|||.:..::|:||:..|...|:...||:..:.:..:
Human   774 L---------------FEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDEL---- 819

  Fly  2890 QNTLVRLQDLVRQREYILSDPNIDA--MEKTEKIEQLDLDGCPIADLGL-----DFVLPGHANIE 2947
                                |::|:  .:....|::.|.|   |.||||     :.|:......|
Human   820 --------------------PSLDSEFYKNLTSIKRYDGD---ITDLGLTLSYDEDVMGQLVCHE 861

  Fly  2948 LCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCG 3012
            |..||:..|||..|...||.|:.::.:...::.|..||..||.|:...:.:|||...||:.:..|
Human   862 LIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISG 926

  Fly  3013 SGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILAS-YNRDEQRAFLQFVTGSPRLPTGG 3076
            ..:|     .:::.|::......|||...:.|.:|::|||| :..||:..||:|||...|.|..|
Human   927 DNAE-----IDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLG 986

  Fly  3077 FKALTPPLTIVRKTLDENQNPNDYLPSVM-------------------TCVNYLKLPDYSSREVM 3122
            |..|.||.:|....:.::|:..|.|.||:                   ||.|.||||:||.:.|:
Human   987 FAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVL 1051

  Fly  3123 RQKLK--VAANEGSMSFHLS 3140
            |:||:  ::.|.|   |.||
Human  1052 REKLRYAISMNTG---FELS 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	96/348 (28%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	118/450 (26%)
UBE3B	NP_569733.2	HECTc	707..1065	CDD:214523	108/411 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900