DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and RSP5

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_011051.3	Gene:	RSP5 / 856862	SGDID:	S000000927	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	961	Identity:	191/961 - (19%)
Similarity:	309/961 - (32%)	Gaps:	342/961 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2298 EDMDDN--VAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGN 2360
            :|:::|  :...|..|..|:.|.|..:|    ..|:.|...:...          |.::.|..|
Yeast    58 DDINENSILTIQVFDQKKFKKKDQGFLG----VVNVRVGDVLGHL----------DEDTATSSG- 107

  Fly  2361 ASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSG-----VQKQQSSS--SSASSCVNATSSC 2418
                        ||.||.:|...   ..|:.....||     :.|..|||  |.|.|...|:||.
Yeast   108 ------------RPREETITRDL---KKSNDGMAVSGRLIVVLSKLPSSSPHSQAPSGHTASSST 157

  Fly  2419 SSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLD 2483
            ::||...:.|.|.:...:.|:|...|        |.|..|.|.|:.  .::...:..|....|.:
Yeast   158 NTSSTTRTNGHSTSSTRNHSTSHPSR--------GTAQAVESTLQS--GTTAATNTATTSHRSTN 212

  Fly  2484 ALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIG 2548
            :                                     .:.|.||.
Yeast   213 S-------------------------------------TSSATRQY------------------- 221

  Fly  2549 MACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQ 2613
                              :||:                  :...|:.|..:||.....||..:
Yeast   222 ------------------SSFE------------------DQYGRLPPGWERRTDNFGRTYYV-- 248

  Fly  2614 AEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTD-LGLWNGSDSYKQNSVTI-- 2675
             :|..:.....:..|: |.|.|.|..|.        .:.||:|.. .|......|...:|||:
Yeast   249 -DHNTRTTTWKRPTLD-QTEAERGNQLN--------ANTELERRQHRGRTLPGGSSDNSSVTVQV 303

  Fly  2676 ---VDVVKANSAVLHIEDALEATTT---------DQNTPAVAGASLVSSSTTTTTTTAQQHQ--- 2725
               .::...|.|......|...||:         :|.......|..|..:|.|||....:.|
Yeast   304 GGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYI 368

  Fly  2726 --HPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTT 2788
              :.||.::.:         ||||    |..|...:...|.:      ||:|....:|:.:.|||
Yeast   369 RTYGPTNTTIQ---------QQPV----SQLGPLPSGWEMRL------TNTARVYFVDHNTKTTT 414

  Fly  2789 ----------ATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGK---------------- 2827
                      ...|.|:........|        |..:...|..|| |:
Yeast   415 WDDPRLPSSLDQNVPQYKRDFRRKVI--------YFRSQPALRILP-GQCHIKVRRKNIFEDAYQ 470

  Fly  2828 --SSKLPQMTKAKAK-------------------------------------------------- 2840
              ..:.|:..|.:..
Yeast   471 EIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNS 535

  Fly  2841 ---------FKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRL 2896
                     |||:|:.:...|...|.||..|....|:.::.::  :.|.|:..|..||.|:|
Yeast   536 GINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKK--VVLQDMEGVDAEVYNSL--- 595

  Fly  2897 QDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGH-----ANIELCRGGRDTP 2956
                   .::|.:               .:||.    |.|.|.....     ..::|...||:..
Yeast   596 -------NWMLEN---------------SIDGV----LDLTFSADDERFGEVVTVDLKPDGRNIE 634

  Fly  2957 VTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSR 3021
            ||..|..:|:.|.|.|.:::.||:||:|..:||:.:.|...:.:|...|||.:..|..
Yeast   635 VTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIA------- 692

  Fly  3022 WEIKMLQESCRTDH-GFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALT---- 3081
             ||.:......||: |:.:..:.||:.::.::.::.:::...|||.||:.|:|..|||.|.
Yeast   693 -EIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDG 756

  Fly  3082 PPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANE 3132
            |....:.|..:..|     ||...||.|.:.||.|...:.|:|||.:|..|
Yeast   757 PRRFTIEKAGEVQQ-----LPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEE 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	87/402 (22%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	191/961 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900