Protein Alignment ctrip and UFD4

DIOPT Version :9

• Sequence 1: NP_001189170.1
• Gene: ctrip / 40596
• FlyBaseID: FBgn0260794
• Length: 3140
• Species: Drosophila melanogaster
• Sequence 2: NP_012915.3
• Gene: UFD4 / 853859
• SGDID: S000001493
• Length: 1483
• Species: Saccharomyces cerevisiae
• Alignment Length: 2233
• Identity: 447/2233 - (20%)
• Similarity: 715/2233 - (32%)
• Gaps: 952/2233 - (42%)

  Fly  1024 TQHGSGSGAAAAVDS---ESDDSEVG----RLQALLE------------ARGLPPHLFGALGPRV 1069
            ||:||........|.   ..|::|.|    .|..:||            :.||..|..|...|.:
Yeast    87 TQNGSDEDRNEEEDGLERSHDNNEFGSNPLHLPDILETFAQRLEQRRQTSEGLGQHPVGRTLPEI 151

  Fly  1070 THILHRTIGNSSSSKA-----NQLLQ--GLQSHDESQQLQAAIEMCQMLVMGNE---------DT 1118
            ..::...:..|:.|.|     ::|::  |..|.|....:::..|:.:.::|.|:         :|
Yeast   152 LSMIGGRMERSAESSARNERISKLIENTGNASEDPYIAMESLKELSENILMMNQMVVDRIIPMET 216

  Fly  1119 LAGFPIKQVVPALI--QLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVE--AVPVFLEKLQVI 1179
            |.|     .:.|::  ::||.|  .::...|||.:..:.|..|.|....|:  .:|:...||..|
Yeast   217 LIG-----NIAAILSDKILREE--LELQMQACRCMYNLFEVCPESISIAVDEHVIPILQGKLVEI 274

  Fly  1180 QCMDVAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFH 1244
            ..:|:|||.|..:|.:||.|.:.||:...:|..:.:.||.:|.|||.|:||.:|.|.::..::|.
Yeast   275 SYIDLAEQVLETVEYISRVHGRDILKTGQLSIYVQFFDFLTIHAQRKAIAIVSNACSSIRTDDFK 339

  Fly  1245 FVAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQ------HDGQRLQQIASPDLLKNCQQLLL 1303
            .:.|.||.|..:.|....:.|      ..|||.:..      |...:.:.:.|.||::...||:.
Yeast   340 TIVEVLPTLKPIFSNATDQPI------LTRLVNAMYGICGALHGVDKFETLFSLDLIERIVQLVS 398

  Fly  1304 VTPAILNTGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRS 1368
            :....|..          .|.|...  |.:..:.:|:.:..|...|...:.|..|..|   .|:|
Yeast   399 IQDTPLEN----------KLKCLDI--LTVLAMSSDVLSRELREKTDIVDMATRSFQH---YSKS 448

  Fly  1369 PSE-LYELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIE 1432
            |:. |:|..              |:..:|||
Yeast   449 PNAGLHETL--------------IYVPNSLL---------------------------------- 465

  Fly  1433 AANQSSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSA 1497
                     ||:|.|                                :..:...:|....||
Yeast   466 ---------ISISRF--------------------------------IVVLFPPEDERILSA--- 486

  Fly  1498 AAGGASTSAAAAAASSNNNNNNNNNPPGNS---VNLNQVKRRPSLDARIACLKEERGLAADFIKH 1559
                                   :...|||   |..||.|    .|:.:.||
Yeast   487 -----------------------DKYTGNSDRGVISNQEK----FDSLVQCL------------- 511

  Fly  1560 IFNVLYEVYSSSAGPNVRYKCLRALLRMVYYATP-----------ELLRQVLKYQLVSSHIAGML 1613
             ..:|.|:|:::|..:||...|.||||:|.....           :|:..:|..:..:|:..|..
Yeast   512 -IPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAINDQLIKLIGSILAQKETASNANGTY 575

  Fly  1614 GSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGVIYQFTQLT-DPNNPICANPSPKPLSATATP 1677
            .|....::||.|.:.:::.::..::|....:|||:......|: |.||
Yeast   576 SSEAGTLLVGGLSLLDLICKKFSELFFPSIKREGIFDLVKDLSVDFNN----------------- 623

  Fly  1678 TANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTP 1742
                                                                             
Yeast   624 ----------------------------------------------------------------- 623

  Fly  1743 SGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSG 1807
               :|....    |..|.|.|              .::||    :|
Yeast   624 ---IDLKED----GNENISLS--------------DEEGD----LH------------------- 644

  Fly  1808 VQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDM-LKRKAPPKR 1871
                                               ||............::.||| :.....||:
Yeast   645 -----------------------------------SSIEECDEGDEEYDYEFTDMEIPDSVKPKK 674

  Fly  1872 KSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSS 1936
            .|                                 :|  :.|..|
Yeast   675 IS---------------------------------IH--IFRTLS-------------------- 684

  Fly  1937 KSRFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSG 2001
                                                                             
Yeast   685 ----------------------------------------------------------------- 684

  Fly  2002 AGLAYTVSQHGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQE 2066
              |||..::        |:|.      :::.:|..|:                         |||
Yeast   685 --LAYIKNK--------GVNL------VNRVLSQMNV-------------------------EQE 708

  Fly  2067 AKRSKAASESGATQSGSSGVGLSSTGNTPLST----AGSTNVLERLSSILFKLNGSYHDCLDALL 2127
            |...:.....|.       |.:....:||..|    .|..:||::.         .:|:
Yeast   709 AITEELHQIEGV-------VSILENPSTPDKTEEDWKGIWSVLKKC---------IFHE------ 751

  Fly  2128 ELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMP 2192
                   :.|:|.||...:||..::...:||.|  |......:||:.||..
Yeast   752 -------DFDVSGFEFTSTGLASSITKRITSST--VSHFILAKSFLEVFED-------------- 793

  Fly  2193 TIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNL 2257
                 ....|:..|...:|:||.|.:                         :.|.|.
Yeast   794 -----CIDRFLEILQSALTRLENFSI-------------------------VDCGLH-------- 820

  Fly  2258 RQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLSQ---ASFRHKLQ 2319
               .||.|.    ::.:.|:..||..|         |.|::::..::::.::|.   |||....:
Yeast   821 ---DGGGVS----SLAKEIKIKLVYDG---------DASKDNIGTDLSSTIVSVHCIASFTSLNE 869

  Fly  2320 FTIGDHVLPYNMTVYQAVKQFSP-LVSEQPETDNESE-------------------------TLL 2358
            |      |.:.|...:.:....| |.|...|.|.|.|                         |:.
Yeast   870 F------LRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFFYDNEKVDMESTVF 928

  Fly  2359 G---NA---------SIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSS--GVQKQQSSSSSAS 2409
            |   |.         ::|...|||.:                     |.|  |..::..::..|
Yeast   929 GVIFNTFVRRNRDLKTLWDDTHTIKF---------------------CKSLEGNNRESEAAEEA- 971

  Fly  2410 SCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADV 2474
                                                     :||      ..|:.|......|.|
Yeast   972 -----------------------------------------NEG------KKLRDFYKKREFAQV 989

  Fly  2475 VTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGN 2539
            .|  .:|.|.|.:|          |.|:.|.|:.:     .||:.|:.||..|||.:|||:.:|.
Yeast   990 DT--GSSADILTLL----------DFLHSCGVKSD-----SFINSKLSAKLARQLDEPLVVASGA 1037

  Fly  2540 LPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDT---TPDLNAAESSERVAPRLDRR 2601
            ||.|...:....||||||:||.|....|||...|.:|...:.   :.||...|:.:::. |:.||
Yeast  1038 LPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQLG-RITRR 1101

  Fly  2602 KRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSD 2666
            |..|||..|......||..:|.|..:|||:|:.|.|||||||||||::||....|..|.:|. .:
Yeast  1102 KLRISRKTIFATGLKILSKYGSSPDVLEIEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMWR-CN 1165

  Fly  2667 SYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRS 2731
            ||...|...||                  |||
Yeast  1166 SYSYRSEMDVD------------------TTD--------------------------------- 1179

  Fly  2732 SSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHN 2796
                                                                             
Yeast  1180 ----------------------------------------------------------------- 1179

  Fly  2797 TTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLP 2861
                  ..|||.           |||.||...|...::.:.   |.:||.|:|::::|:|:||..
Yeast  1180 ------DYITTL-----------LFPEPLNPFSNNEKVIEL---FGYLGTFVARSLLDNRILDFR 1224

  Fly  2862 FSLPFYRWLVSEEHSIGLADLMRVAPEVQNTL--VRLQD--LVRQREYILSDPNIDAMEKTEKIE 2922
            ||..|:..|    |.:...::..|..:|:..|  :.|.|  |.:..:||:::.:
Yeast  1225 FSKVFFELL----HRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKD----------- 1274

  Fly  2923 QLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALRE 2987
                |...:..|.|.|.:||:.:|||..||.:..:...|:.:||..|....|.:|::||.:|..|
Yeast  1275 ----DNMTLESLSLTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIE 1335

  Fly  2988 GFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILA 3052
            ||..||..:|:.:.:|:||..:| |...|.    |.:..|..:...:||:..||..|.....|::
Yeast  1336 GFSKVFSYERMLILFPDELVDIF-GRVEED----WSMATLYTNLNAEHGYTMDSSIIHDFISIIS 1395

  Fly  3053 SYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYS 3117
            ::.:.|:|.||||:||||:||.||||:|.|..|:|.|..::....::||||||||.||||||.|:
Yeast  1396 AFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYT 1460

  Fly  3118 SREVMRQKLKVAANEGSMSFHLS 3140
            |:::||.:|..|..||:.:|.||
Yeast  1461 SKDIMRSRLCQAIEEGAGAFLLS 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922	4/71 (6%)
		FAM199X	<1985..2074	CDD:292442	11/88 (13%)
		HECTc	<2818..3138	CDD:294058	111/323 (34%)
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354	309/1575 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I647
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	450	1.000	Inparanoid score	I249
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102181
Panther	1	1.100	-	-	LDO	PTHR45670
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3704
SonicParanoid	1	1.000	-	-		X3310
TreeFam	1	0.960	-	-
	10	9.940