DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and HUL4

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	996	Identity:	197/996 - (19%)
Similarity:	345/996 - (34%)	Gaps:	312/996 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2337 VKQFSPLVSEQPETDNE-SETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQK 2400
            |..|..|.:::...|.. |:.||.::    ..||.:..|.....||..:..|:....|||:....
Yeast     2 VSLFDKLNAKKDGRDGSVSKELLSHS----VAHTKNRLPKSGRRTSERSLAASVKDGSCSNSKSN 62

  Fly  2401 QQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPF 2465
            :::||:|.|.  ....||..|......|..|...|  |.:||.....:        |.:...:|.
Yeast    63 KRNSSASVSG--EEDKSCLISLNCLCCGVPLRFPA--SITKFRCSACQ--------VTVIVKEPE 115

  Fly  2466 LSSSLPADVVTVQDASLDALCML----------------------------RVIHALNRHWDHLY 2502
            ::|:|.:.  |....:|:.|.|:                            .:.:.|:|..|
Yeast   116 INSNLESS--THISCTLEGLQMVVRRCHDDLQRLKKTGILDKERKGLIFQPVITYLLDRFHD--- 175

  Fly  2503 GCVVRQNIIPQSDFIHP--KIMAKANRQLQDPLVIMTGNLPQWLPQIGMAC-------------- 2551
                 .:|:.:|..:|.  |.:...|.::......:..|||...|...|.|
Yeast   176 -----VSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYYSMLCCCNDLLKRITINKG 235

  Fly  2552 PFLFPFETRHLLF------YATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEI 2610
            ..|...:.|.||.      ..|...|||..:         |..|:.:..|...:..||.|.....
Yeast   236 ENLQILQYRWLLIILNIPTIRTCLIRDRKSK---------NVFETQQIRAVSYELAKRCIGYLSN 291

  Fly  2611 L--KQAEHILQ--------DFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGS 2665
            |  |.::.::|        :|.:...:|.: |.|         .:|..|:|.||          |
Yeast   292 LSTKTSQQLIQSLRRTPTDNFSYQVEILNL-YIN---------FQFSRLLSNEL----------S 336

  Fly  2666 DSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQ------- 2723
            :...:|:|...|.:::.....|        ||        |...:|:...:..:..:|
Yeast   337 NRTAKNNVKPEDEMRSRLRRHH--------TT--------GHEFLSTRPISAQSNDKQGSGFTHP 385

  Fly  2724 ----------------HQHPPTRSSSRSHVL---RSGAG-----------------QQPVEHSSS 2752
                            |.|...:.:...:|.   |:|.|                 :|..:|...
Yeast   386 VNNKMKFKFFQYEEDWHIHSAAKLTFIYYVANTRRNGRGALSIQSFYNITLDFIDYKQDFDHWRG 450

  Fly  2753 SAGANENALNMVIAQQFSDT--------------------------------NSANPA---AIDN 2782
            .  |.:..:|.:|.:..:.|                                :.|..|   ::|.
Yeast   451 V--AQKTKMNQLIEEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDK 513

  Fly  2783 PSST------TTATTVVQHNTT------------------TNNSSIIT--------TTTTTSYVH 2815
            ..|.      .....|:.|::.                  .|...|..        ...|.|..:
Yeast   514 GKSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFN 578

  Fly  2816 AVHGLFPLPLGKSSKL------PQMTKAKAK------FKFLGKFMAKAVMDSRMLDLPFSLPFYR 2868
            .::||| :.:.:||:.      |...|:|.|      :...|..|..|:.:|.:|||.|....|:
Yeast   579 PMNGLF-IYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYK 642

  Fly  2869 WLVSEEHSIGLADLMRVAPEVQNTLVRL----------------QDLVRQREYILSDPNIDAMEK 2917
            .|.||  .:...|...:.||....|:::                :...|...:||:|      .|
Yeast   643 KLCSE--PLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILND------SK 699

  Fly  2918 TEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQF 2982
            :.|                     .:..:|||..||:.|:|..|.|:::.....::|.:.::.|:
Yeast   700 SSK---------------------EYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQY 743

  Fly  2983 EALREGFDSVF-PIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQY 3046
            .....||..|| ....:::|..||||.:.||   :::.::::.|.|:...:...||..||:|:.:
Yeast   744 NKFVSGFKRVFAECNSIKLFNSEELERLVCG---DEEQTKFDFKSLRSVTKYVGGFSDDSRAVCW 805

  Fly  3047 LYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYL 3111
            .:||:.|::...|:..|||||.|.|:|..|...:...::::      ..:.:|.||...||.|.:
Yeast   806 FWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLL------GSHDSDDLPLAHTCFNEI 864

  Fly  3112 KLPDYSSREVMRQKLKVAANE 3132
            .|.:|||::.:..||..|.||
Yeast   865 CLWNYSSKKKLELKLLWAINE 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	88/344 (26%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	197/996 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900