Protein Alignment ctrip and GAS7

DIOPT Version :9

• Sequence 1: NP_001189170.1
• Gene: ctrip / 40596
• FlyBaseID: FBgn0260794
• Length: 3140
• Species: Drosophila melanogaster
• Sequence 2: NP_958839.1
• Gene: GAS7 / 8522
• HGNCID: 4169
• Length: 476
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 113/638 - (17%)
• Similarity: 204/638 - (31%)
• Gaps: 255/638 - (39%)

  Fly  1783 PRQYVH-FQQPAVPAPPPQQE----LLPSGVQQ----QGQQ--VPQVIYQPHHQQPAHLVLASTS 1836
            |..||. .::|.:..|||.:|    :||.|.|.    ||::  |.....:...::|      |:|
Human    53 PASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERP------SSS 111

  Fly  1837 SGAASSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPS 1901
            .|..:|..|..||                 .||   :.:|..|             ||....||.
Human   112 PGIPASPGSHRSS-----------------LPP---TVNGYHA-------------SGTPAHPPE 143

  Fly  1902 SSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFLASLNPARWGR 1966
            ::    |..:.::|                           |:|.|.|||        :|::  :
Human   144 TA----HMSVRKST---------------------------GDSQNLGSS--------SPSK--K 167

  Fly  1967 QTHQN--------HHHHHQQSQQQHHGLSKD----------SGNSNSTGSGSGAGLAYTVSQHGA 2013
            |:.:|        ..|.....:||   |.|.          :...:..|:|:.||....:.:...
Human   168 QSKENTITINCVTFPHPDTMPEQQ---LLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLK 229

  Fly  2014 GSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGA 2078
            |.            .:.|.:|              :::||: :...:.|.:..||.|:  :...:
Human   230 GK------------QMQKEMS--------------EFIRER-IKIEEDYAKNLAKLSQ--NSLAS 265

  Fly  2079 TQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEV 2143
            .:.||.|   .:......|.|....|..:.|:.|
Human   266 QEEGSLG---EAWAQVKKSLADEAEVHLKFSAKL------------------------------- 296

  Fly  2144 NHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMPTIEPIAFGAFVAKLNG 2208
             ||.:.|.::|:..:    .::|  ::...|..|.|    ..|...:..::|. |..|...:...
Human   297 -HSEVEKPLMNFREN----FKKD--MKKCDHHIADL----RKQLASRYASVEK-ARKALTERQRD 349

  Fly  2209 CVTQLEQFPVKVHDFPAGPGGRSNQS-----ALRFFNTHQ----LKC-NLQRHPQCNNLRQWKGG 2263
            ...:.:|..:|:          ||::     ..|..:|..    ::| :|....|.....:....
Human   350 LEMKTQQLEIKL----------SNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTT 404

  Fly  2264 TVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLP 2328
            |::::.|    .:||..::|                               :|..|:|...|...
Human   405 TLELERL----EVERVEMIR-------------------------------QHLCQYTQLRHETD 434

  Fly  2329 -YNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQH-TIHYRPVEEEV 2379
             :|.:..:.|.|.  |....|..|.|         :||::| |.:.|||:.|:
Human   435 MFNQSTVEPVDQL--LRKVDPAKDRE---------LWVREHKTGNIRPVDMEI 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	15/98 (15%)
		HECTc	<2818..3138	CDD:294058
GAS7	NP_958839.1	SH3_GAS7	5..57	CDD:212763	1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..171		26/150 (17%)
		WW_FCH_linker	109..201	CDD:374680	31/168 (18%)
		F-BAR_GAS7	214..446	CDD:153333	52/351 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900