DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ctrip and TOM1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:NP_010745.3 Gene:TOM1 / 852068 SGDID:S000002865 Length:3268 Species:Saccharomyces cerevisiae


Alignment Length:2444 Identity:432/2444 - (17%)
Similarity:780/2444 - (31%) Gaps:821/2444 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1056 GLPPHLFGALG--PRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGNEDT 1118
            |||..:|..|.  |::.:...:|           |||....:||..::.|...:.::|....:| 
Yeast  1287 GLPSRIFTVLPFYPKLVNAFAKT-----------LLQIFTKYDEPTEVFAGRILDRILETDLDD- 1339

  Fly  1119 LAGFPIKQVVPALIQLLRMEHNFDIMNN-------ACRALAYMLEALPRSSGTVVEAVPVFLEKL 1176
                      ||.:..|  .|.|.|..|       |...:...:|.|.:|........|.|.:.|
Yeast  1340 ----------PATLSSL--IHLFGIFLNEKYIYQKASHLMQRFIEYLEKSLKPEHVNTPWFSKAL 1392

  Fly  1177 QVIQCMDVAEQSLSALEILSR-----------------------RHNKAILQANGISACLTYLDF 1218
            .|.:.: :|:..|..||.||:                       :....:::.:.||      :|
Yeast  1393 YVYEII-LAKSELPHLEELSKDVLLRYPLLSMAKVFRIPDPMKQKLFDILIRVSDIS------NF 1450

  Fly  1219 FSIVAQRAALAIAANCCLNMHPEEFHF--VAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQH 1281
            :|.:|....|...:.       :|.:.  :|.| .:|:|||                :::.||  
Yeast  1451 YSALATSRILIFYSR-------DELYANNIARS-GILSRLL----------------KVIGSF-- 1489

  Fly  1282 DGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLY 1346
              |:|.:|   :.|::  ..||:|                 ..|....:...:|:|.:|..:...
Yeast  1490 --QKLDKI---NFLES--SFLLLT-----------------RRCFETTENVDALIRAEINRSFTA 1530

  Fly  1347 LLTGNAEPAAASATHV-----ELISRSPSELYELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQ 1406
            ...|..:.|....|.:     .::.||||:..::.|                             
Yeast  1531 RPLGGGDDAVRELTTILEEKAHVVMRSPSQFIDVLC----------------------------- 1566

  Fly  1407 DQVHWQWRDDRGSWHNYSTIDSRLI---EAANQSSEDEISLSTFGRTYTVDFHAMQQINEDTGTT 1468
            :...:...||:|:..:||.  .|.:   :...|:|..|.|                .|.|.||  
Yeast  1567 ETARFHEFDDQGALVDYSL--KRFLGEKDKNTQASSTEKS----------------DIYERTG-- 1611

  Fly  1469 RPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAASSNNNNNNNNNPPGNSVNLNQV 1533
                  :.|..::.:.|..:....|                             .|.||.:|.:.
Yeast  1612 ------IMHLLLSQLMAASEKDWLS-----------------------------EPANSSDLPEN 1641

  Fly  1534 KRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKCLRALLRMVYYATPE---- 1594
            |:        |.|...|.....::..:..:|.|:.||.  ...:::.|....|..|...|.    
Yeast  1642 KK--------AQLDPSRNPVCAYMIFLLKLLVELVSSY--NQCKFEFLTFSRRNTYAERPRPRTT 1696

  Fly  1595 ----LLRQVL---------KYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRRE 1646
                .|.::|         |::.....:.|||..:   :::|.|...:.......||        
Yeast  1697 AINFFLYRLLDKPVGTDHDKHEAKRREVIGMLARS---VIIGFLATVQDDRTTKTDV-------- 1750

  Fly  1647 GVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPFF----------- 1700
                   :|.||:.......:   :.|......|| .|.|....:|.|:::.:|           
Yeast  1751 -------KLADPHMNFIRKFA---IEAIIKAIRNA-TSSSKLLESNHLKLDMWFRIITSMVYVQA 1804

  Fly  1701 ------MDSAP---------------GLSSASTTPSSSKHQSY--SVKSFSHAMNALTASAKGTP 1742
                  :||..               ||.|..|...:|...:|  |.|.|:.|:.||.       
Yeast  1805 PYLRQLLDSNKVEADQYQLCKLVIDLGLPSVITEAMASIDLNYPFSKKIFNVAVEALN------- 1862

  Fly  1743 SGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSG 1807
                  |.|||.   .|:|.            :|..:..|                   |:....
Yeast  1863 ------TISSTR---NNFSE------------HFKIEDHD-------------------EVEDEV 1887

  Fly  1808 VQQQGQQVPQVI------------YQPHHQQPAHLV----------------------------- 1831
            .:...:::|.:.            .:........|:                             
Yeast  1888 DESDKEEIPDMFKNSALGMYDVEDIEEDDDDDTSLIGDDDAMAFVDSDNGFEVVFSDEDDDMGEE 1952

  Fly  1832 ----LASTSSGAASSSSSSSSSSSASALQHKMTD----MLKRKAPPKRKSQSGGRAKSRQEDAAV 1888
                ..|.|.....||...||::..:.:.:::.|    ::....|      ||...:....||.:
Yeast  1953 DADDARSDSEENELSSEMQSSTADGTDVDYEVDDADGLIINIDQP------SGDDEEMADYDANI 2011

  Fly  1889 APAGSGPGGAPPSSSGSAMHELLSRATSLGSG--------NGGRSTPNSGGGS------GSSKSR 1939
            :.:...     .:...::|..:......|.||        :...|..:||..|      .|..|.
Yeast  2012 SHSSHS-----ENEDDASMDVIEVYDDELSSGYDVDLSDYDVDESDWDSGLSSLSISDEDSESSE 2071

  Fly  1940 FNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDS-GNSNSTGSGSGAG 2003
            ....||:..|.|:..:|.:                       :...|:.|| |.|.....|...|
Yeast  2072 DEPINSTRMGDSRRRWLIA-----------------------EGVELTDDSQGESEEDDRGVFRG 2113

  Fly  2004 LAYTVSQHGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAK 2068
            :.:..|           |.......:...:.|.|...:.||......:...::..:.|....::.
Yeast  2114 IEHIFS-----------NENEPLFRVHDEMRHRNHHRSINRTHFHSAMSAPSLSLLNRGRRNQSN 2167

  Fly  2069 RSKAASESGATQ---SGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHD--CLDALLE 2128
            .......:|..|   ..|..|.::.:|:.|.|..      ...|.:|  ::||:.|  .||.::.
Yeast  2168 LINPLGPTGLEQVENDISDQVTVAGSGSRPRSHH------LHFSEVL--VSGSFFDEPVLDGIIL 2224

  Fly  2129 LKTILLESDISPFEVNHSG------LIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEPLLQN 2187
            ..|:....||  |::.:..      :|..::|.:...:..:::|                  |:|
Yeast  2225 KSTVSRWKDI--FDMFYDSKTYANCIIPTVINRLYKVSLALQKD------------------LEN 2269

  Fly  2188 VGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHP 2252
                                    :.||..:|            |::.|  ||    :..::.|.
Yeast  2270 ------------------------KREQEKLK------------NKNLL--FN----EAKVESHN 2292

  Fly  2253 QCNNLRQWKGGTVKIDPLAMVQAIER-----YLVVRG----YGGIRADSDDDSEEDMDDNVAAVV 2308
            ..:.:      :|:.|.:........     |:.::|    .||  .|.|.:....:.|::.|.|
Yeast  2293 SSDAI------SVEQDDIQESNVTHDDHEPVYVTIQGSEVDIGG--TDIDPEFMNALPDDIRADV 2349

  Fly  2309 LSQASFRHKLQFTI-GDHVLPYNMTVYQAVKQFSPLVSEQ-----PETDNESETLLG--NASIWV 2365
            .:|.....:.:..: .||    |:...:....|...:.|.     .:|:.|.:.:.|  .:|..|
Yeast  2350 FAQHVRERRAEARLNSDH----NVHSREIDSDFLEAIPEDIREGILDTEAEEQRMFGRIGSSADV 2410

  Fly  2366 QQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGS 2430
            .:........:|||.:|...|  :|:...::..:|::.:....:..::       .:|:|    |
Yeast  2411 IRADDDVSNNDEEVENGLDHG--NSNDRNNADPEKKKPARIYFAPLID-------RAGIA----S 2462

  Fly  2431 LTKKAHKSSSKFMRKKTELWH-------------------------EGIAPV--------VISA- 2461
            |.|....|.....|   |::|                         |||...        :||: 
Yeast  2463 LMKSVFISKPYIQR---EIYHELFYRLCSSKQNRNDLMNTFLFILSEGIIDQHSLEKVYNIISSR 2524

  Fly  2462 ----LKPFLSSSLPADV--VTVQDASLDALCML-----RVIHALNRHWDHLYGCVV-------RQ 2508
                .|......||:|.  :||.:.:::.|..|     |:.:.|....|:|   :|       |:
Yeast  2525 AMGHAKTTTVRQLPSDCTPLTVANQTIEILQSLIDADSRLKYFLIAEHDNL---IVNKANNKSRK 2586

  Fly  2509 NIIPQSDFIHP--KIMAKANRQL-QDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLL------- 2563
            ..:|......|  .:.:..:|:| .|..|:|     ..|.:|...|.     :|..:|       
Yeast  2587 EALPDKKLRWPLWHLFSLLDRKLITDESVLM-----DLLTRILQVCT-----KTLAVLSTSSNGK 2641

  Fly  2564 ------FYATSFDRD----------------RALQRLLDTTPDLNAAESSERVAPRLDRRKRAIS 2606
                  |:..|||.|                |..|:.|:...:|:..:....:..: .....|||
Yeast  2642 ENLSKKFHLPSFDEDDLMKILSIIMLDSCTTRVFQQTLNIIYNLSKLQGCMSIFTK-HLVSLAIS 2705

  Fly  2607 RTEILKQA-EHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAE-------LQRTDLGLWN 2663
            ....||.| :.:.::.|.....:||..|         .|:.:.|.|::       |...|. |:.
Yeast  2706 IMSKLKSALDGLSREVGTITTGMEINSE---------LLQKFTLPSSDQAKLLKILTTVDF-LYT 2760

  Fly  2664 GSDSYKQNSV----TIVDVVKANSAVLHIEDALEATTTDQ--NTPAVAGASLVS--------SST 2714
            .....::.:|    ::.|.:........:.:.|......|  ||.|.....|:.        |..
Yeast  2761 HKRKEEERNVKDLQSLYDKMNGGPVWSSLSECLSQFEKSQAINTSATILLPLIESLMVVCRRSDL 2825

  Fly  2715 TTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEH-SSSSAGANENALNMVIAQQFSDTNSANPA 2778
            :....||.:::.......|::.          ||: ......|::..||.:|        .:||.
Yeast  2826 SQNRNTAVKYEDAKLLDFSKTR----------VENLFFPFTDAHKKLLNQMI--------RSNPK 2872

  Fly  2779 AIDNPSSTTTATTVV-------------------------------------------QHNTTTN 2800
            .:..|.:.......|                                           :.|....
Yeast  2873 LMSGPFALLVKNPKVLDFDNKRYFFNAKLKSDNQERPKLPITVRREQVFLDSYRALFFKTNDEIK 2937

  Fly  2801 NSSIITTTTTTSYVHA------------------VHGLF-PLPLGKSSKLPQMTKA-----KAKF 2841
            ||.:..|....|.|.|                  .:.|| |:|..|::..|..|..     .:.|
Yeast  2938 NSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFF 3002

  Fly  2842 KFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYI 2906
            ||:|..:.||:.|...||..||...|:.::.  ..:.|.|:..:.|:...:||          :|
Yeast  3003 KFIGMIIGKAIRDQCFLDCHFSREVYKNILG--RPVSLKDMESLDPDYYKSLV----------WI 3055

  Fly  2907 LSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTY 2971
            |.:...|.:|:|..:|..|..              .|..|.|..||:|..||..|...|:..|..
Yeast  3056 LENDITDIIEETFSVETDDYG--------------EHKVINLIEGGKDIIVTEANKQDYVKKVVE 3106

  Fly  2972 WFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHG 3036
            :.|...|::|.:....||.::.....:.:|..:|||.:..|. .:.....|      ::..|...
Yeast  3107 YKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGL-PDIDVDDW------KNNTTYVN 3164

  Fly  3037 FHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYL 3101
            :....:.:.|.:..:.|::.:|:...||||||:.::|..|||.|:....:.:.::..:...::.|
Yeast  3165 YTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERL 3229

  Fly  3102 PSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            ||..||.|.|.||.|.|.|.:|..|.:|.|||...|.|:
Yeast  3230 PSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGFGLA 3268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922 15/74 (20%)
FAM199X <1985..2074 CDD:292442 14/89 (16%)
HECTc <2818..3138 CDD:294058 86/325 (26%)
TOM1NP_010745.3 DUF908 92..387 CDD:399185
DUF913 448..>683 CDD:399192
MSCRAMM_ClfB <1879..2061 CDD:411414 24/211 (11%)
DUF4414 2328..2357 CDD:405126 8/30 (27%)
HUL4 2385..3268 CDD:227354 193/973 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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