DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and KAK

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001329354.1	Gene:	KAK / 830017	AraportID:	AT4G38600	Length:	1888	Species:	Arabidopsis thaliana

Alignment Length:	2445	Identity:	609/2445 - (24%)
Similarity:	920/2445 - (37%)	Gaps:	811/2445 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   942 AAALSAARDVGGGSDGGGSAGGATPATGASASS-VGNTSAVGASSSSNSSAGQAASSNSNNVTAT 1005
            |.|.|||          .|:..::|....|||. ...:.....||||:||......|:|....:.
plant     9 AEATSAA----------PSSSSSSPPPPPSASGPTTRSKRARLSSSSSSSLAPTPPSSSTTTRSR 63

  Fly  1006 GSGSAPGGGPTSTGT-TSGTQHG-----------------------------------------S 1028
            .|.||....|..|.| :||.:.|                                         :
plant    64 SSRSAAAAAPMDTSTDSSGFRRGGRGNRGNNNDNSDKGKEKEHDVRIRERERERDRAREQLNMDA 128

  Fly  1029 GSGAAAAVDSESD-DSEVGR--------------LQALLEARGLPPHLFGALGPRVTHILHRT-I 1077
            .:.||.:.|.:.| |||.|.              ||.||.          .||..:..:|..: |
plant   129 AAAAARSADEDDDNDSEDGNGGFMHPNMSSASSALQGLLR----------KLGAGLDDLLPSSGI 183

  Fly  1078 GNSSSSKAN----QLLQGLQSH-DESQQLQAAIEMCQMLVMGNEDTLAGFPIKQVVPALIQLLRM 1137
            |::|||..|    ::|.||::. :|.:|::|..::|:||.:|.||:|:.|.:...||.|:.||..
plant   184 GSASSSHLNGRMKKILSGLRAEGEEGKQVEALTQLCEMLSIGTEDSLSTFSVDSFVPVLVGLLNH 248

  Fly  1138 EHNFDIMNNACRALAYMLEALPRSSGTVVE--AVPVFLEKLQVIQCMDVAEQSLSALEILSRRHN 1200
            |.|.|||..|.|||.::.:.||.|...||.  ||...:.:|..|:.||:|||||.||:.:|:.|.
plant   249 ESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVSCLVARLLTIEYMDLAEQSLQALKKISQEHP 313

  Fly  1201 KAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFVAESLPLLARLLSQQDKKCI 1265
            .|.|:|..:.|.|:||||||...||.||:.|||.|..:..:...:|.|::|||..||...|.|.:
plant   314 TACLRAGALMAVLSYLDFFSTGVQRVALSTAANMCKKLPSDASDYVMEAVPLLTNLLQYHDSKVL 378

  Fly  1266 ESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVT-----PAILNTGTFTAVVRMLSLMC 1325
            |.......|:.|:|....::|.::.:..|:.....|:..:     .|.|:..|:|.::|:|| .|
plant   379 EYASICLTRIAEAFAPYPEKLDELCNHGLVTQAASLISTSNSGGGQASLSVSTYTGLIRLLS-TC 442

  Fly  1326 CSCPDLAI-SLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSELYELTCLIGELMPRLPLD 1389
            .|...|.. :||...|::.|..:|.|:...|.||.:  ..:||...::||:..|..||:|.||
plant   443 ASGSPLGFRTLLLLGISSILKDILLGSGVSANASVS--PALSRPADQIYEIVNLANELLPPLP-- 503

  Fly  1390 GIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIEAANQSSEDEISLSTFGRTYTVD 1454
                                                             |..|||.|
plant   504 -------------------------------------------------EGVISLPT-------- 511

  Fly  1455 FHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAASSNNNNNN 1519
                                                            ||:|....:....::.:
plant   512 ------------------------------------------------STNALVKGSCQKKSSPS 528

  Fly  1520 NNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKCLRAL 1584
            .:   |...::.::..|..|      |.::..|...|...:..||.::|.||....:|:|||..:
plant   529 TS---GKQEDILKISPREKL------LGDQPELLQQFGLDLLPVLVQIYGSSVNGTIRHKCLSVI 584

  Fly  1585 LRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGVI 1649
            .:::|:::.|:::.::....:||.:||:|...|.:::|.|||:|||||.:||:.|...|.||||:
plant   585 GKLMYFSSSEMIQSLIGDTNISSFLAGVLAWKDPQVLVPALQVAEILMEKLPETFSKVFVREGVV 649

  Fly  1650 YQFTQLTDPNNPICANPSPK-----PLSATA------TPTANAGGSQSA----PASANSLQVNPF 1699
            :...||.....|..|:|:.|     |.||.:      :..||:.|:||.    |||. ::..|..
plant   650 HAVDQLVLVGKPSHASPTDKDNDCVPGSARSRRYRRRSSNANSDGNQSEEPKNPASL-TIGANHN 713

  Fly  1700 FMDSAPGLSSASTTPSSSKHQSYSVKSFS---------------HAMNALTASAKGTPSGALDAT 1749
            .:|: |..|.......||..:::..|.|.               |..|..|....|.....:...
plant   714 SLDT-PTASFMLRETVSSCAKAFKDKYFPSDGGDVDVGVTDDLLHLKNLCTKLTAGIDDHKVKGK 777

  Fly  1750 SSSTTAGGY--NYSSSAPS------------------------SSSGAPAA--------YF---- 1776
            ..|..:|.:  ::|:|...                        ..||..||        ||
plant   778 GKSKASGPFLGDFSASKEEYLIGVISEILGEISKGDGVSTFEFIGSGVVAALLNYFSCGYFSKEK 842

  Fly  1777 --------VTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQG--------QQVPQVIYQPHHQ 1825
                    :.|:| .|::..|.:.|:|....:.::.|..|..|.        ::.|.|:..|
plant   843 ISELNLPKLRQEG-LRRFKAFLEVALPFDGNEGKVPPMTVLIQKLQNALSSLERFPVVLSHP--- 903

  Fly  1826 QPAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKAPPK--RKSQSG------------ 1876
                         :.|.|.|:..||..|||.|.:...|.|.:..|  |...|.
plant   904 -------------SRSLSGSARLSSGLSALAHPLKLRLCRASGEKTLRDYSSNIVLIDPLASLAA 955

  Fly  1877 ---------GRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGG 1932
                     .|::|..:.|  ||.|:...|..||.:|      :|..:|        |||.|...
plant   956 VEEFLWPRVQRSESALKPA--APIGNTEPGTLPSGAG------VSSPSS--------STPASTTR 1004

  Fly  1933 SGSSKSR--FNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNS 1995
            ..||:||  .|.|::|..           :|..                         :.|.|:|
plant  1005 RHSSRSRSAINIGDTSKK-----------DPVH-------------------------EKGTSSS 1033

  Fly  1996 TGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVK 2060
            .|.|.|                                    ::..|..::..|
plant  1034 KGKGKG------------------------------------VMKPAQADKGPQ----------- 1051

  Fly  2061 RYTEQEAKRSKAASESGATQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDA 2125
              |...|:: :|..:.......:||...|......:|..                     |..||
plant  1052 --TRSNAQK-RAVLDKDTQMKPASGDSSSEDEELEISPV---------------------DIDDA 1092

  Fly  2126 LLELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQ 2190
            |     ::.|.|||..|.:.:                                   |.:|.:...
plant  1093 L-----VIEEDDISDDEDDDN-----------------------------------EDVLDDSLP 1117

  Fly  2191 MPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDF-------------------PAGPGGRSNQSAL 2236
            |.|                       |.||||.                   ||. ||.|..:|.
plant  1118 MCT-----------------------PDKVHDVKLADSVDDDGLATSGRQMNPAS-GGTSGAAAA 1158

  Fly  2237 R--------FFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYG-----GI 2288
            |        ..|::..:                 |.:.....||.          |.|     ||
plant  1159 RASDSIDTGIGNSYGSR-----------------GALSFAAAAMA----------GLGAASGRGI 1196

  Fly  2289 RADSDDDSEEDMDDNVAAVVLSQASFR-HKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDN 2352
            |...|          :....|:::|.. .||.||.....|..::|:||||::...|..:..:...
plant  1197 RGSRD----------LHGRTLNRSSDEPSKLIFTAAGKQLSRHLTIYQAVQRQLMLDEDDDDRFG 1251

  Fly  2353 ESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSS 2417
            .|:.:..:.|.:...:||.|:..:.:|...:..||:|::.|                   .:|.|
plant  1252 GSDLVSSDGSRFNDIYTIMYQRPDSQVNRLSVGGASSTTPS-------------------KSTKS 1297

  Fly  2418 CSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASL 2482
            .:::|.|.|       ::|::                     |.|...|...||.| :...:::.
plant  1298 ATTNSSVES-------QSHRA---------------------SLLDSILQGELPCD-LEKSNSTY 1333

  Fly  2483 DALCMLRVIHALNRHWDHLYGCVVRQNI-----------------IPQSDFIHPKIMAKANRQLQ 2530
            :.|.:|||:..||:....|....:....                 :|..:|::.|:..|..||:|
plant  1334 NVLALLRVLEGLNQLCPRLRAQTLSDRFAEGKITSLDDLSTTAAKVPLDEFVNSKLTPKLARQIQ 1398

  Fly  2531 DPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERV- 2594
            |.|.:.:|:||.|..|:..||||||||:||...||:|:|...|||.||........:..::||.
plant  1399 DALALCSGSLPSWCYQLTRACPFLFPFQTRRQYFYSTAFGLSRALNRLQQQQGADGSGSTNEREM 1463

  Fly  2595 -APRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTD 2658
             ..||.|:|..:||..||..|..:::.:...||:||::|..|||||||||||||.|:|.:||:..
plant  1464 RIGRLQRQKVRVSRNRILDSAAKVMEMYSSQKAVLEVEYFGEVGTGLGPTLEFYTLLSHDLQKAS 1528

  Fly  2659 LGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQ 2723
            ||:|
plant  1529 LGMW------------------------------------------------------------- 1532

  Fly  2724 HQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTT 2788
                  ||||...|... .|:..:|....|| ||.:
plant  1533 ------RSSSGDKVSMQ-IGRDEIEDGKPSA-ANRD----------------------------- 1560

  Fly  2789 ATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLP---QMTKAKAKFKFLGKFMAK 2850
                                    .|.|..||||.|...::.:.   |..|....|:.||:.|||
plant  1561 ------------------------IVLAPLGLFPRPWPSTADISEGGQFHKVIEYFRLLGRVMAK 1601

  Fly  2851 AVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAM 2915
            |:.|.|:||:|.|..||:.::.:|  :.|.|::....|:..||..|:.:|.::.|:.....
plant  1602 ALQDGRLLDVPLSTAFYKLILGQE--LDLHDIVLFDAELGKTLQELRVVVARKHYLEGVGG---- 1660

  Fly  2916 EKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQK 2980
            :.:..|..|.|.||.|.||.|:|.|||:....|..|  |..|.:.||.:|||||....:..||.:
plant  1661 DNSSTISDLCLRGCRIEDLSLEFTLPGYPEYILRSG--DEIVDITNLEEYISLVVDATVKRGVTR 1723

  Fly  2981 QFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQ 3045
            |.||.|.||:.||.|..|::|.|.||:.:.||     :...||::.|.|..:.|||::..|.||.
plant  1724 QIEAFRSGFNQVFDITSLQIFTPSELDYLLCG-----RRELWEVETLAEHIKFDHGYNAKSPAII 1783

  Fly  3046 YLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRK----------TLDENQNPNDY 3100
            .|.||:.....|:||||.|||||:||||.||...|.|.||||||          ....::..:|.
plant  1784 NLLEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKHSSTSSAAANGAGASETADDD 1848

  Fly  3101 LPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            |||||||.||||||.||::|:|.:||..|.|||..||.||
plant  1849 LPSVMTCANYLKLPPYSTKEIMYKKLLYAINEGQGSFDLS 1888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922	5/71 (7%)
		FAM199X	<1985..2074	CDD:292442	11/88 (13%)
		HECTc	<2818..3138	CDD:294058	135/332 (41%)
KAK	NP_001329354.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	278	1.000	Domainoid score	I411
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	710	1.000	Inparanoid score	I126
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34110at2759
OrthoFinder	1	1.000	-	-		FOG0004709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102181
Panther	1	1.100	-	-	LDO	PTHR45670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830