DRSC/TRiP Functional Genomics Resources

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Protein Alignment ctrip and WWC2

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_011530571.1 Gene:WWC2 / 80014 HGNCID:24148 Length:1216 Species:Homo sapiens


Alignment Length:1351 Identity:249/1351 - (18%)
Similarity:426/1351 - (31%) Gaps:434/1351 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1775 YFV------TQQGDPRQYVHFQQPAVPAPPPQQELLPS--GVQQQGQQVPQVIYQPHHQQPAHLV 1831
            |::      ||..|||:....:         |:::|..  .|.|...:..:.:|   |.:...|.
Human    74 YYIDHINKTTQIEDPRKQWRGE---------QEKMLKDYLSVAQDALRTQKELY---HVKEQRLA 126

  Fly  1832 LA--------------STSSGAASSSSSSSSSSSASALQHKM-TDMLKRKAPPKRKSQ------- 1874
            ||              |:|..:..|.||||:......|:.:: |..|:.|...:..||       
Human   127 LALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLY 191

  Fly  1875 -SGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLSRATSLGSG------------------ 1920
             ..|....:|.|..::   .|..|...|.:.:.:.||.|...::.||                  
Human   192 KEQGFETLQQIDKKMS---GGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERF 253

  Fly  1921 ----NGGRSTPN---SGGGSGSSKSR--FNAGN----SSNAGSSKSSFLASLNPARWGRQTHQNH 1972
                |.|||.|:   |...|....||  .:||:    |.:.|....|.||  ...|...|     
Human   254 HLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLA--EKVRLSLQ----- 311

  Fly  1973 HHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASI----SKSI 2033
               ::::::                  |.|.|...:|:..:.:..|.|:.......:    .:.:
Human   312 ---YEEAKR------------------SMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELL 355

  Fly  2034 SHANLLAAANR--------ERARQWVREQAVD--------FVKRYTEQEAKR------------- 2069
            .....:....|        |..||.:.|:.:.        ..:|...:|.::             
Human   356 KELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLT 420

  Fly  2070 ----SKAASESGATQSGSSGVGL----SSTGNTPLSTAGSTNVLER----LSSILFKLNGSYHDC 2122
                |:..|.|.:|.|.|||..|    ||.|:...|:.||.|.|..    .||...:::..|...
Human   421 TYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYK 485

  Fly  2123 LDALLELK---------TILLESDI--SPFEVNHSGLIKAMLNYMTSETG----LVERDARLRSF 2172
            ||.||:.|         |.:.|:::  ||.:...|||    .....:.||    |.|....:.| 
Human   486 LDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGL----CGVAAAATGHTPPLAEAPKSVAS- 545

  Fly  2173 MHVFAGLPLEPLLQNVGQMPTIEP-----IAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSN 2232
                        |.:...:.::.|     :..|.|                        |...|:
Human   546 ------------LSSRSSLSSLSPPGSPLVLEGTF------------------------PMSSSH 574

  Fly  2233 QSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDS- 2296
            .::|..|......|.|..|                  .|.:..||..:::        |||... 
Human   575 DASLHQFTADFEDCELSSH------------------FADISLIENQILL--------DSDSGGA 613

  Fly  2297 ----EEDMDDNVAAVVLSQASFRHKLQFTIGD--HVLPYNMTVYQAVKQFSPLVSEQPETDNESE 2355
                .||.|.|..|        |..|.....|  ..||....::                     
Human   614 SQSLSEDKDLNECA--------REPLYEGTADVEKSLPKRRVIH--------------------- 649

  Fly  2356 TLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSS 2420
             |||                  |.|:..:|..:..|.:..|||  .::.....|...:.|.|...
Human   650 -LLG------------------EKTTCVSAAVSDESVAGDSGV--YEAFVKQPSEMEDVTYSEED 693

  Fly  2421 SSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADV-----VTVQDA 2480
            .:.|.:....:..:.:..||.||             |:|:.|:...:..:|...     |.|..:
Human   694 VAIVETAQVQIGLRYNAKSSSFM-------------VIIAQLRNLHAFLIPHTSKVYFRVAVLPS 745

  Fly  2481 SLDALCMLRV-IHALNRH--WDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLV---IMTGN 2539
            |.|..|:.|. :|.....  ::.::...:.|..:.|.. :...:.:.:..:.::.|.   |...:
Human   746 STDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKT-LRVDLCSVSKHRREECLAGTQISLAD 809

  Fly  2540 LP-------QW---LPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERV 2594
            ||       .|   ||...|.|.             ....:.|...|      |:....:|.:  
Human   810 LPFSSEVFTLWYNLLPSKQMPCK-------------KNEENEDSVFQ------PNQPLVDSID-- 853

  Fly  2595 APRLDRRKRAISRT--EILKQAEHILQDFGHSKALLEIQYENEVGTGL-------GPTLEFYALV 2650
               ||.....::||  |:|...:.:.|             |.|..:|.       |..|..|.|.
Human   854 ---LDAVSALLARTSAELLAVEQELAQ-------------EEEEESGQEEPRGPDGDWLNTYFLC 902

  Fly  2651 SAELQRTDLGLWNGSDSYKQNSV----TIV-----DVVKANSAVLHIEDALEATTTDQNTPAVAG 2706
            ..||:         .|.:.:.:|    |::     ::|....|.:.:.:  :::.|:..:...:.
Human   903 CWELK---------DDVFTRLTVKPLLTMLREASDEIVAEKEAEVKLPE--DSSCTEDLSSCTSV 956

  Fly  2707 ASLVSSSTTTTTTTAQQ-HQHPPTR-------SSSRSHVLRSGAGQQPVEHSSSSAGANENALNM 2763
            ..:........:..|:. ...||||       .::...........:|.|.||.|:..:....:.
Human   957 PEMNEDGNRKESNCAKDLRSQPPTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSS 1021

  Fly  2764 VI--AQQFS--DTNS----ANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGL 2820
            ||  :|.||  :.|.    .|.:  |:.|||....::...|:|...|..:..|...|.:...   
Human  1022 VIVRSQTFSPGERNQYICRLNRS--DSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRT--- 1081

  Fly  2821 FPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRV 2885
                   :.:.|..|....:.    ...|.....||:.|...:|...|..:.|..:.|..||...
Human  1082 -------TQECPVRTSLDLEL----DLQASLTRQSRLNDELQALRDLRQKLEELKAQGETDLPPG 1135

  Fly  2886 APEVQNTLVRLQDLVRQREYILSDPNIDAME--KTEKI-EQLDLDGCPIAD 2933
            ..|.:    |.|.|::|.|........:..:  ..||: .|:..|.|.:.:
Human  1136 VLEDE----RFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLRE 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922
FAM199X <1985..2074 CDD:292442 14/125 (11%)
HECTc <2818..3138 CDD:294058 23/119 (19%)
WWC2XP_011530571.1 WW 12..41 CDD:278809
WW 59..88 CDD:278809 3/13 (23%)
DUF342 <283..385 CDD:302792 20/129 (16%)
YlqD 351..>428 CDD:287979 8/76 (11%)
C2_Kibra 700..823 CDD:176062 22/136 (16%)
vWFA <1058..>1153 CDD:294047 23/112 (21%)
Phage_Nu1 <1117..1192 CDD:294991 16/70 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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