DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and herc5.2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	1070	Identity:	219/1070 - (20%)
Similarity:	368/1070 - (34%)	Gaps:	304/1070 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2218 VKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVV 2282
            :::.|......|:..|..|:......:.|.             :.|.|.:.....|..:::|.|.
Zfish    58 LRLRDEDCNQDGKLKQLDLKREKIRSIVCG-------------EDGAVLLADGGKVLLMDKYTVC 109

  Fly  2283 RGYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQ 2347
            |...|:             ||...:           |...||              |.|..:|..
Zfish   110 RPLKGL-------------DNTKVI-----------QIACGD--------------QHSVALSND 136

  Fly  2348 PETDNESETLLGNASIWVQQHTI----HYR-----PVEEEVTSG------AAAGAASSSSSCSSG 2397
            .:.....|...|...:..:|..|    |.:     ||.:....|      :.:|......|.|:|
Zfish   137 GQLFVWGENAHGQLGLRKEQALIQSPQHLQSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAG 201

  Fly  2398 --------------VQKQQSSSSSAS-SCVNATSSCSSSSGV--ASGGGSLTKKAHKS--SSKFM 2443
                          :.|..|...:.| ||....::..|..|.  ..|.|...:..|.|  .....
Zfish   202 QLGLGDTTDRFVPTIVKSLSGKKTVSISCGGEHTATLSKGGTVFTFGSGGFGQLGHNSLKDEHHP 266

  Fly  2444 RKKTELWHEGIAPV--------VISALKPFLSS-----------------SLPADVVTVQDASLD 2483
            |...|||...::.|        |:.||...:.|                 |:|..|:...|.:.:
Zfish   267 RLVAELWGSKVSQVTCGRHHTLVLVALTNRIYSFGCGMQGQLGNGEQVKQSVPLPVLLPTDCNCE 331

  Fly  2484 ALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPK-IMAKANRQLQDPLV--IMTGNLPQWLP 2545
             ..|.::| |..:|...|:    .:|  |.::...|| .|......|.|.::  .::|:.| | |
Zfish   332 -FTMEKII-AGEKHSFALF----FKN--PGNESTKPKSSMNGGILTLNDRMIDRWVSGSYP-W-P 386

  Fly  2546 QI---------GMAC---PFLFP-FETRHLLFYATSF----DRDRALQRLLDT-----TPDLN-- 2586
            .:         ...|   .||.| .:.:.......||    |.::.:..::..     .|.||
Zfish   387 TVKKEIKKVFSSAVCLNGSFLKPSLDEQDFDLVGKSFSKLTDNEKVISEVVKVIQQTLLPSLNPK 451

  Fly  2587 -AAESSER---VAPRLDRRKRAISRTEILKQ-AEHILQDFGHSKALLEIQYENEVGTGLGPTLEF 2646
             |.|.|.|   :.|.|.:......|:|:.|. |..|||....::.:||:.:.......|...::.
Zfish   452 PAHEESLRLYLLLPELIKGLEQYQRSELNKALASKILQLNSAAREMLEMFWSKLPDDWLKSLVKL 516

  Fly  2647 YALVSAEL--------QRTDLGLWNGSDSYKQNSVTIV------------DVVKANSAVLHIED- 2690
            :...||:|        ..:||       .:.||.:.|:            |:..::..:..|.|
Zfish   517 FHKESADLIDYMSVCAMDSDL-------KHLQNLLRILQMAYKVCCSTHRDITISDFIIYEISDL 574

  Fly  2691 --ALEATTTD--QNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSS 2751
              ||:||..|  ...|.|....::........|.....:.|..                 .:::|
Zfish   575 LNALQATIDDLADWDPFVDYVYMMKLRDYFIKTLEILVKFPFV-----------------ADYAS 622

  Fly  2752 SSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTT------TT 2810
            .....|...:.|:  ::.|:....|            ||..|.|   .|..|::..|      .|
Zfish   623 KRGIFNHLEIKMI--RRSSNRFLGN------------ATFNVLH---INRESLLMDTLKYLRQNT 670

  Fly  2811 TSYVHA------------VHGL----FPLPLGKS-------------SKL----PQMTKAKAKFK 2842
            .|:.|.            :.||    |.| :.||             |.|    |..|:....|.
Zfish   671 HSFSHLSRVAFIGEDGIDMRGLSAEFFSL-ISKSFLKWDKKILEVHPSSLVWFNPHHTRGNKNFY 734

  Fly  2843 FLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAP-EVQNTLVRLQDLVRQREYI 2906
            :||.....|:.:...:::.|.|..::.|:.::.|  |.||..::| |.::    |::|:::.|
Zfish   735 YLGVICGMALYNRHHINIDFPLALFKKLLQQKPS--LDDLEELSPVEARS----LKNLLKEDE-- 791

  Fly  2907 LSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTY 2971
                           |.:||       |.|||.:.||   ||...|....|...|..:|:.|...
Zfish   792 ---------------EVVDL-------LFLDFTVKGH---ELVPNGSQIQVNKVNRQKYVDLYVD 831

  Fly  2972 WFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHG 3036
            :...:.|:.|||....||....|:....||:||||:.:..||      .::..|..|:|...: |
Zfish   832 FVFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGS------PQYNWKEFQQSASYE-G 889

  Fly  3037 FHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYL 3101
            .....:.|:..:.:....:.:.::.||.|:.|:.|:|.|||....     ::.:..:..:|:|:|
Zfish   890 CSASDELIKNFWTVFFELSEEHKKKFLMFLYGTERVPAGGFSKRR-----IKISTRDCPDPDDHL 949

  Fly  3102 PSVMTCVNYLKLPDYSSREVMRQKLKVAAN 3131
            |...||...|.||.|:....:|.||..|.|
Zfish   950 PKAQTCFGRLVLPKYTDINTLRNKLTHAIN 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	86/336 (26%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274	7/53 (13%)
		RCC1	136..186	CDD:278826	8/49 (16%)
		RCC1	189..238	CDD:278826	9/48 (19%)
		RCC1	242..290	CDD:278826	10/47 (21%)
		RCC1	296..347	CDD:278826	9/52 (17%)
		HECTc	649..985	CDD:294058	94/380 (25%)
		HECTc	678..984	CDD:214523	86/348 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900