DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and Hectd3

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_780453.1	Gene:	Hectd3 / 76608	MGIID:	1923858	Length:	861	Species:	Mus musculus

Alignment Length:	295	Identity:	81/295 - (27%)
Similarity:	127/295 - (43%)	Gaps:	47/295 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  2839 AKFKFLGKFMAKAVMDSRMLDLPFSLPFYRW--LVSEEHSIGLADLMRVAPEVQNTLVRLQDLVR 2901
            ||::::|:.|..|:.....|.|  :||.:.|  |..||.|     ..:..|.|.:.||:|
Mouse   596 AKYEWIGQLMGAALRGKEFLVL--ALPGFVWKQLSGEEVS-----WSKDFPAVDSVLVKL----- 648

  Fly  2902 QREYILSDPNIDAMEKTEKIEQLDLD-GCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQY 2965
                      ::.||..:| |..:.. |   .:|....||.....:||..||....|...:..::
Mouse   649 ----------LEVMEGVDK-ETFEFKFG---KELTFTTVLSDQQVVELIPGGTGIVVEYEDRSRF 699

  Fly  2966 ISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQES 3030
            |.||....|.|. ::|..|::.|...|.|...|.:...:|||...||.      ....:..|::.
Mouse   700 IQLVRKARLEES-KEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGD------PEVTVDALRKL 757

  Fly  3031 CRTDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQ 3095
            .|.: .|......:||.:|.|.::..:::..||:||||..|||.   :....|..:..:|
Mouse   758 TRFE-DFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPA---RIYIYPDKLGYET----- 813

  Fly  3096 NPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAA 3130
              .|.||...||.:.|.||.|:|.:|..:||:.||
Mouse   814 --TDALPESSTCSSTLFLPHYASAKVCEEKLRYAA 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	81/295 (27%)
Hectd3	NP_780453.1	APC10-HECTD3	238..371	CDD:176487
		HECTc	528..849	CDD:214523	81/295 (27%)
		HECT	586..845	CDD:279026	79/292 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900