DRSC/TRiP Functional Genomics Resources

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Protein Alignment ctrip and Ubr5

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_006520242.1 Gene:Ubr5 / 70790 MGIID:1918040 Length:2800 Species:Mus musculus


Alignment Length:3588 Identity:616/3588 - (17%)
Similarity:1060/3588 - (29%) Gaps:1315/3588 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SVKSQSLSALTEGQHDDGGSTATSATLANKTSGTNTTSASNHSSQRRRNNNTNSNRNKSHHKNEK 68
            ||:...|. |.:..::||..       .|.:|||..||        |....::|....|..:...
Mouse    73 SVQPDRLE-LGKPDNNDGSK-------LNSSSGTGRTS--------RPGRTSDSPWFLSGSETLG 121

  Fly    69 RNAPATSGPAVSSSVDVVPATSTASATSTRRSRSQGRHSSAAALSSKESQIPK----RSVGAIRS 129
            |.|..|.|...||.|            ......|.||.|:.|..|.:::::.:    |..|.:.|
Mouse   122 RLAGNTLGSRWSSGV------------GGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGS 174

  Fly   130 PSSPAFNSIP--VVSDQSLSPG-------SRK---RQLNQHNNS-----NNKASSSHQSAPGGDQ 177
            ...|.   ||  |:.::.:|..       ||.   |:|.:.|..     ||..|...:....||.
Mouse   175 QPQPV---IPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDD 236

  Fly   178 LVCAPLKKRRLQQSLGSGICEGAVEINLGAASFDHTPRQASGDCVAQRTRSKTISP-EELPSTSS 241
                                                            |.|::..| |:|.|...
Mouse   237 ------------------------------------------------TASESYLPGEDLMSLLD 253

  Fly   242 AAAARHHQIRPSA---SSTSFSSSHRNKRKASIGGSIAAVETTPHRGTAAARAGRSGNLLNYYRK 303
            |..   |...||.   :...||.            .|:.......|.::.:|.|.|..||     
Mouse   254 ADI---HSAHPSVIIDADAMFSE------------DISYFGYPSFRRSSLSRLGSSRVLL----- 298

  Fly   304 TRKVSHTRSSQKSEKQSIPAEDTTANRNGSAGSGSSSKSGVIPKNRKS-LRHSQQNLLDTEAAEV 367
                             :|.|                :...:.:.|:| ||..::..||..:.:.
Mouse   299 -----------------LPLE----------------RDSELLRERESVLRLRERRWLDGASFDN 330

  Fly   368 ESAAAETGGEQQSEHGNLDVIDQLPT---------PE--------AGPNQSEASGIHNQSQLEAD 415
            |..:....||...:..|..|  |.|.         |:        .|...||...:.::.:|...
Mouse   331 ERGSTSKEGESNPDKKNTPV--QSPVSLGEDLQWWPDKDGTKFTCIGALYSELLAVSSKGELYQW 393

  Fly   416 RQPVVQDEDDEEDDEEEEEEEEEEVGFYGIVN------SAGSSYEEDTQIVAEEDEITTEEEVDD 474
            :    ..|.:...:.:..........|.|:.|      ||.|.   ...:..|.:::.|..    
Mouse   394 K----WSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSI---RATVATENNKVATWV---- 447

  Fly   475 EDDDEIEEEDLSESEFAQQLIGELGGER---------------------------QQPQRATNNA 512
               ||......|:.|...|...||.|||                           .|.::....|
Mouse   448 ---DETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENNLYWWGVVPFSQRKKMLEKA 509

  Fly   513 KKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAPGAGGGGPRATRSSNSNSSNNVVDY 577
             :.||..|..:|..:.....|..|....:.....|....|.....|.|:.          .|:..
Mouse   510 -RAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKV----------GVLME 563

  Fly   578 SI--MPHLTTVATTTPHALTPQQHQQQRQPPQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFVTP 640
            |:  |.........:|.:|...:...:....:|.| :|:.|..:..||.              :|
Mouse   564 SVWNMNDSCRFQLRSPESLKSMEKASKTLETKPES-KQEPVKTEMGPPP--------------SP 613

  Fly   641 TAAAAAAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYH------------- 692
            .:..:.|::.|    :||:..|   ::........:::.|.:.|.|......             
Mouse   614 ASTCSDASSIA----SSASMPY---KRRRSTPAPREEEKVNEEQWPLREVVFVEDVKNVPVGKVL 671

  Fly   693 ----SSVAVLHQPPPHHFTST----GAGP---PPALFQQQAPPQLTRY--TPATATTAATFVPPQ 744
                :.|||..   |...|:|    .:||   |.:|.|.   .:|.|.  .....|.....||..
Mouse   672 KVDGAYVAVKF---PGTSTNTTCQNSSGPDADPSSLLQD---CRLLRIDELQVVKTGGTPKVPDC 730

  Fly   745 QQQV---VYNPQQQQHSSLRRSSRG-----KTGS----CVSSAAAAQQQQHHQ----------QQ 787
            .|:.   :..|::.:..::...|:|     ||||    ||...|..:.:|.:.          |.
Mouse   731 FQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGSWVRYCVFDLATGKAEQENNFPTSSVAFLGQD 795

  Fly   788 QHSSAAAAVQQQL-----------------------------LPP-----PGTYQYQQVGGNT-- 816
            :.|.|.....|:.                             |||     .|.:....:..|:  
Mouse   796 ERSVAIFTAGQESPIVLRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTI 860

  Fly   817 ------VVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQ----HQQQQRATLVQP 871
                  :::||..|..:|...:...:....:....:|....:|..|..|    |:......::..
Mouse   861 KKKAAIIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNLQMLQTFISHRCDGNRNILHA 925

  Fly   872 GFLFSY-RSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPPHAGGQQITPGANS 935
            .....: .||:..::::.|::..:.......||. :|:..::.... .:||.:..|     .:||
Mouse   926 CVSVCFPTSNKETKEEEEAERSERNTFAERLSAV-EAIANAISVVS-SNGPGNRAG-----SSNS 983

  Fly   936 ANL---SIVAAALSAARDVGGGSDGGGSAGGATPATG--ASASSVGNTSAVGASSSSNSSAGQAA 995
            .:|   .::..:|.|| .:|....|..|:....|.:.  |..|.|.:..::......:.....|.
Mouse   984 RSLRLREMMRRSLRAA-GLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPSMDPDGDIDFILAPAV 1047

  Fly   996 SSNSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSESD------------DSEVGR- 1047
            .|.:  ..|||||..|     ||.|..|.     |...:.|:|:..            ||.|.: 
Mouse  1048 GSLT--TAATGSGQGP-----STSTIPGP-----STEPSVVESKDRKANAHFILKLLCDSAVLQP 1100

  Fly  1048 -LQALL---EARGLPPHLFGALG---PRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAI 1105
             |:.||   :|||:.|.:....|   |....||         ..|.::.:...|..|.:      
Mouse  1101 YLRELLSAKDARGMTPFMSAVSGRAYPAAITIL---------ETAQKIAKAEVSASEKE------ 1150

  Fly  1106 EMCQMLVMGNEDTLAGFPIKQVVPALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVEAVP 1170
                      ||...|    .|.|                                |||..:..|
Mouse  1151 ----------EDVFMG----MVCP--------------------------------SGTNPDDSP 1169

  Fly  1171 VFLEKLQVIQCMDVAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCC 1235
            ::     |:.|.|....:.:..|.:::                   |.|..   |....:.:.||
Mouse  1170 LY-----VLCCNDTCSFTWTGAEHINQ-------------------DIFEC---RTCGLLESLCC 1207

  Fly  1236 LNMHPEEFHFVAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQHDGQ--RLQQIASPDLLKNC 1298
                                        |.|  |:..|       |.|.  :|:: .||....:|
Mouse  1208 ----------------------------CTE--CARVC-------HKGHDCKLKR-TSPTAYCDC 1234

  Fly  1299 QQLLLVTPAILNTGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLY-LLTGNAEPAAASATHV 1362
            .:.                        |.|..|...  :......||| |||         ||::
Mouse  1235 WEK------------------------CKCKTLIAG--QKSARLDLLYRLLT---------ATNL 1264

  Fly  1363 ELISRSPSELYELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQW-----RDDRG---- 1418
            ..:..|..|         .|:       :|.|.      |:..|...|.|:     |:||.    
Mouse  1265 VTLPNSRGE---------HLL-------LFLVQ------TVARQTVEHCQYRPPRIREDRNRKTA 1307

  Fly  1419 ---------------------------SWHNYSTIDSRLIEAANQSSEDEISLST-FGRTYTVDF 1455
                                       .|:...:    :|...:|.::|.:|.|: .|       
Mouse  1308 SPEDSDMPDHDLEPPRFAQLALERVLQDWNALRS----MIMFGSQENKDPLSASSRIG------- 1361

  Fly  1456 HAMQQ----INEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAASSNNN 1516
            |.:.:    :|:.:||.|  .....|..:...:|...|..|..|:..                 .
Mouse  1362 HLLPEEQVYLNQQSGTIR--LDCFTHCLIVKCTADILLLDTLLGTLV-----------------K 1407

  Fly  1517 NNNNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSSAG-----PNV 1576
            ...|...||        :|..::...:..|:.        :..:|.:|....:||..     |..
Mouse  1408 ELQNKYTPG--------RREEAIAVTMRFLRS--------VARVFVILSVEMASSKKKNNFIPQP 1456

  Fly  1577 RYKCLRALLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGT 1641
            ..||.|....::.||..||                             ..:||.|:..:      
Mouse  1457 IGKCKRVFQALLPYAVEEL-----------------------------CNVAESLIVPV------ 1486

  Fly  1642 HFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPG 1706
               |.|:                          |.|||                  ||      .
Mouse  1487 ---RMGI--------------------------ARPTA------------------PF------T 1498

  Fly  1707 LSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGA 1771
            |:|.|........:.:||:                   .|....||..|          ||||.:
Mouse  1499 LASTSIDAMQGSEELFSVE-------------------PLPPRPSSDQA----------SSSSQS 1534

  Fly  1772 PAAYFVTQQGDPRQ-YVHFQQPAVPAPPPQQELLPSGVQQ-------QGQQVPQVIYQPHHQQPA 1828
            .::|.:.   :|:| .:...||.......|.:::.:.|::       .|::      ..|.:|..
Mouse  1535 QSSYIIR---NPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEE------DHHDEQEE 1590

  Fly  1829 HLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGS 1893
            |     ....|.:...........|.::   .|:|   |..:.:|.|... .|.|::|       
Mouse  1591 H-----GEENAEAEGHHDEHDEDGSDME---LDLL---AAAETESDSESN-HSNQDNA------- 1636

  Fly  1894 GPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKS----- 1953
                       |....:::.||: ||..|..|.|   .......|:.|..:.|::.||:|     
Mouse  1637 -----------SGRRSVVTAATA-GSEAGASSVP---AFFSEDDSQSNDSSDSDSSSSQSDDIEQ 1686

  Fly  1954 -SFLASLNPARWGRQTHQNHHHHHQQSQQ------QHHGLSKDSGNSNSTGSGSGAGLAYTVSQH 2011
             :|:......|....:|.|......:|.|      ||...:..:.:|.||.:.|.|||.|....:
Mouse  1687 ETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNPQHQRAASTAPSSTSTPAASSAGLIYIDPSN 1751

  Fly  2012 GAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVD---FVKRYTEQEAKRSKAA 2073
            ...||....:|||.||::..|.:.:.|.:|::..||...|..|..|   .:.:|......:..||
Mouse  1752 LRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAA 1816

  Fly  2074 SESGATQSGSSGVGLSS--------TGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELK 2130
                ...:....|.|.:        |.|..:|...||....|..|.|.......|          
Mouse  1817 ----VKLTYQDAVNLQNYVEEKLIPTWNWMVSVMDSTEAQLRYGSALASAGDPGH---------- 1867

  Fly  2131 TILLESDISPFEVNHSGLIKAMLNYMTS--ETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMPT 2193
                     |....|:....|....||:  |..|...:.|.|:.:          |....|.|. 
Mouse  1868 ---------PNHPLHASQNSARRERMTAREEASLRTLEGRRRATL----------LSARQGMMS- 1912

  Fly  2194 IEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLK----------CNL 2248
                |.|.|:                             ..||....:|..:          |:|
Mouse  1913 ----ARGDFL-----------------------------NYALSLMRSHNDEHSDVLPVLDVCSL 1944

  Fly  2249 QRHPQC-NNLRQW---KGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVL 2309
            :..... ..|..|   ......:|...:.:...|.|:..|     .|::|...|:.||...:..|
Mouse  1945 KHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELG-----IDNEDSEHENDDDTSQSATL 2004

  Fly  2310 SQAS--------------FRHKLQFTIGDHV--LPYNMTVYQAVKQFSPLVSEQP---ETDNESE 2355
            :...              ||.....|....:  .|:.:.:.:|:    || ::||   :.:...|
Mouse  2005 NDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAI----PL-ADQPHLLQPNARKE 2064

  Fly  2356 TLLGNASIWVQQHTIHYRPVEEEVTSGAAAG----AASSSSSCSSGVQKQQSSSSSASSCVNATS 2416
            .|.|             ||.:...:|.|.:|    ..:...:|...:..:.|.:::..:.:|..:
Mouse  2065 DLFG-------------RPSQGLYSSSAGSGKCIVEVTMDRNCLEVLPTKMSYAANLKNVMNMQN 2116

  Fly  2417 SCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEG-IAPVVISALKPFLSSSLPADVVTVQDA 2480
                           .:|........:.::.:....| .||.|.:.||    |||.|: :.:.::
Mouse  2117 ---------------RQKKEGEEQSLLAEEADSSKPGPSAPDVAAQLK----SSLLAE-IGLTES 2161

  Fly  2481 SLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFI-----HPKIMAKANRQLQ---------- 2530
            ....|...|                      ||..|:     |..::.:....|:          
Mouse  2162 EGPPLTSFR----------------------PQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDV 2204

  Fly  2531 --DPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLF------YATSFDRDRALQRLLDTTPDLNA 2587
              :|..|:|        ::|       .||.:...|      ......||.:|:..:|...||..
Mouse  2205 GAEPGSILT--------ELG-------GFEVKESKFRREMEKLRNQQSRDLSLEVKVDRDRDLLI 2254

  Fly  2588 AESSERVAPRLDRR----KRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYA 2648
            .::..::.....||    ..|:.|                    :::.:::|.|.|.|....||.
Mouse  2255 QQTMRQLNNHFGRRCATTPMAVHR--------------------VKVTFKDEPGEGSGVARSFYT 2299

  Fly  2649 LVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSS 2713
            .::                                         :|..:::..|.:......:..
Mouse  2300 AIA-----------------------------------------QAFLSNEKLPNLDCIQNANKG 2323

  Fly  2714 TTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPA 2778
            |.|:.....:::....|...|...:|..:|.:        ||:..:.......|...||....||
Mouse  2324 THTSLMQRLRNRGERDREREREREMRRSSGLR--------AGSRRDRDRDFRRQLSIDTRPFRPA 2380

  Fly  2779 AIDNPS-----------------------------STTTA------------------------- 2789
            :..|||                             |..|.                         
Mouse  2381 SEGNPSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVD 2445

  Fly  2790 ---TTVVQHNTTTNNSSIITTTTTTS-----------------------------------YVHA 2816
               ..::.|.......||:......|                                   |...
Mouse  2446 EAMELIIAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLEDTDDGDDNAPLFYQPG 2510

  Fly  2817 VHGLF-PLPLGKSSKLPQMTKAKAK-FKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEE---HS 2876
            ..|.: |.| ||:      |:|:.. |:.:|:.:...::.:.:..:..:....:.|:..:   |.
Mouse  2511 KRGFYTPRP-GKN------TEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHD 2568

  Fly  2877 IGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVL- 2940
            ....|     |.:..:|         |:.||:..:.||             ....:.:.|.|.: 
Mouse  2569 FAFFD-----PVMYESL---------RQLILASQSSDA-------------DAVFSAMDLAFAID 2606

  Fly  2941 ----PGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMF 3001
                .|...:||...|.:.|||..|:::|:.......::...::...|:|:|...|.|...|...
Mouse  2607 LCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDL 2671

  Fly  3002 YPEELECVFCGSGSEQQHSRWEIKMLQE--SCRTDHGFHQDS--QAIQYLYEILASYNRDEQRAF 3062
            ..|:...:..|.|..      .::||..  |...:.|.:.:.  |..::.:.|:...:..|::..
Mouse  2672 TAEDFRLLVNGCGEV------NVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDL 2730

  Fly  3063 LQFVTGSPRLPTG--GFKALTPPLTIVRKTLDENQNPND-YLPSVMTCVNYLKLPDYSSREVMRQ 3124
            :.|.|.||.||..  ||:.: |.:||        :.|:| :||:..||::.|.:|.|||:::::|
Mouse  2731 VYFWTSSPSLPASEEGFQPM-PSITI--------RPPDDQHLPTANTCISRLYVPLYSSKQILKQ 2786

  Fly  3125 KLKVAANEGSMSF 3137
            ||.:|....:..|
Mouse  2787 KLLLAIKTKNFGF 2799

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669 13/68 (19%)
WWE 1409..1481 CDD:128922 18/112 (16%)
FAM199X <1985..2074 CDD:292442 25/91 (27%)
HECTc <2818..3138 CDD:294058 73/337 (22%)
Ubr5XP_006520242.1 CUE_UBR5 184..230 CDD:270606 10/45 (22%)
ZnF_UBR1 1177..1244 CDD:197698 19/150 (13%)
PolyA 2391..2454 CDD:197769 2/62 (3%)
HECTc 2469..2797 CDD:214523 74/376 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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