DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and Herc6

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_080268.1	Gene:	Herc6 / 67138	MGIID:	1914388	Length:	1003	Species:	Mus musculus

Alignment Length:	342	Identity:	83/342 - (24%)
Similarity:	137/342 - (40%)	Gaps:	64/342 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  2810 TTSYVHAV--------HGLFPLP-LGKSSKLPQMTK-AKAKFKFLGKFMAKAVMDSRMLDLPFSL 2864
            ::.:.|.:        :.:|..| .|.|...|...| .|:.:...|.....::.:.::::|||.|
Mouse   703 SSEFFHCIFEEMTDPKYEMFIYPEKGSSMWFPVNPKFEKSSYFLFGILCGLSLHNLKVINLPFPL 767

  Fly  2865 PFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDP---NIDAMEKTEKIEQLDL 2926
            ..|:.|::::.|                   |:||..     ||.|   |:.        |.|:.
Mouse   768 ALYKKLLNQKPS-------------------LEDLKE-----LSLPLGRNLQ--------EVLNC 800

  Fly  2927 DGCPIADLGLDF-VLPGHANIELCRGGRDTPVTVHNLHQYIS-LVTYWFLIEGVQKQFEALREGF 2989
            :...|.:|.:.| :.....:::|...|...||...|...|:| .|.|.|.| .::..:|....||
Mouse   801 EAGDIEELHMYFSIYWDQKDVDLIPDGISVPVNETNKRDYVSKYVDYIFNI-SIKTIYEEFHRGF 864

  Fly  2990 DSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILASY 3054
            ..|.....:|.|.||||.....|:.:    ..|  |..:.:.:...|:.:....|...::.....
Mouse   865 YKVCNWDIIRQFQPEELMTAIIGNAT----CDW--KQFENNSKYKDGYDKSHPTILLFWKAFHDL 923

  Fly  3055 NRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVR--KTLDENQNPNDYLPSVMTCVNYLKLPDYS 3117
            ..||::.||.|:||..||..   |.|.....:.|  :|..|..||..     :||...|.||.||
Mouse   924 TLDEKKKFLLFLTGCDRLHV---KGLQNEGIVFRCSETFSEEDNPRS-----LTCHRMLDLPKYS 980

  Fly  3118 SREVMRQKLKVAANEGS 3134
            |...|::.|:||.|..:
Mouse   981 SMRRMKEALQVAINNST 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	82/326 (25%)
Herc6	NP_080268.1	RCC1 1	40..91
		RCC1	40..89	CDD:278826
		RCC1 2	92..144
		RCC1	92..142	CDD:278826
		RCC1	145..195	CDD:278826
		RCC1 3	146..197
		RCC1_2	183..211	CDD:290274
		RCC1 4	199..252
		RCC1_2	237..266	CDD:290274
		RCC1 5	253..303
		RCC1	253..300	CDD:278826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281
		chaperonin_like	<570..>652	CDD:295468
		HECTc	658..999	CDD:238033	83/342 (24%)
		HECTc	682..999	CDD:214523	83/342 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900