DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and Smurf2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_079757.2	Gene:	Smurf2 / 66313	MGIID:	1913563	Length:	748	Species:	Mus musculus

Alignment Length:	299	Identity:	90/299 - (30%)
Similarity:	141/299 - (47%)	Gaps:	47/299 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  2841 FKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREY 2905
            |.|:|:.|..||.....:|..|:||||:.|:.:  ||.|.|:..|.|::.|:||          :
Mouse   483 FHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK--SITLDDMELVDPDLHNSLV----------W 535

  Fly  2906 ILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANI---ELCRGGRDTPVTVHNLHQYIS 2967
            ||.:.....::.|..:|.                 ..:..|   ||...|:..|||..|..:|:.
Mouse   536 ILENDITGVLDHTFCVEH-----------------NAYGEIIQHELKPNGKSIPVTEENKKEYVR 583

  Fly  2968 LVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCR 3032
            |...|..:.|::.||.||::||:.|.|...|:.|..:|||.:.||.| :...|.|::....:.|.
Mouse   584 LYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLG-KIDVSDWKVNTRLKHCT 647

  Fly  3033 TDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALT----PPLTIVRKTLDE 3093
                  .||..:::.::.:..::.:.:...|||||||.|:|..|||||.    |.|..:.: :|.
Mouse   648 ------PDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQ-IDA 705

  Fly  3094 NQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANE 3132
            ..|   .||...||.|.:.:|.|.|.|.:.:||..|..|
Mouse   706 CTN---NLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEE 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	90/299 (30%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736
		WW	298..330	CDD:197736
		HECTc	393..745	CDD:238033	90/299 (30%)
		HECTc	420..745	CDD:214523	90/299 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900