DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ctrip and Huwe1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_006528996.1 Gene:Huwe1 / 59026 MGIID:1926884 Length:4456 Species:Mus musculus


Alignment Length:3362 Identity:624/3362 - (18%)
Similarity:1011/3362 - (30%) Gaps:1216/3362 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SVKSQSLSALTEGQHDDGGSTATSATLANKTSGTNTTSASNHSSQRRRNNNTNSNRNKSHHKNEK 68
            |:.||..:|       ||....||.|..::..|.:|...:....:.:..:.| |...|...|..|
Mouse  2086 SLNSQVFAA-------DGAPAETSTTGTSQGEGASTPEETREGKKDKEGDRT-SEEGKQKSKGSK 2142

  Fly    69 RNAPATS-----GPAVSSSVDV-------------------------------VPATSTASATST 97
            ...|.::     ...|.|.|.:                               :|.|..|....|
Mouse  2143 PLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDT 2207

  Fly    98 RRSRSQGRHSSAAALSSKESQIP-----KRSVG----------------AIRSPSSPAFNSIPVV 141
            .........|.|||.|..::|:.     |.::|                |:....|....|.|..
Mouse  2208 PALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMESCPST 2272

  Fly   142 SDQSLSPGSRKRQLNQHNNSNNKASSSHQSAPGGDQLVCAPLKKRRLQQSLGSGICEGAVEINLG 206
            |....|..::    .|||..||                   :.:..|::.|.:.:......::|.
Mouse  2273 SSFYSSATAK----TQHNGMNN-------------------IIRLFLKKGLVNDLARVPHSLDLS 2314

  Fly   207 AASFDHTPRQASGDCVAQRTRSKTISPEELPSTSSAAAARHHQIRPSASSTSFSSSHRNKRKASI 271
            :.:..:|...|   .....|.|:.::.......|.:|::::...:.:..::..||||  ::....
Mouse  2315 SPNMANTVNAA---LKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSH--QQDPGE 2374

  Fly   272 GGSIAAVETTPHRGTAAARAGRSGNLLNYYRKTRKVSHTRSSQKSEKQSIPAE-------DTTAN 329
            .|. |.|:...|..|....|  .|::::...:|..|......:....|.:..|       |....
Mouse  2375 PGE-AEVQEEDHDVTQTEVA--DGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLE 2436

  Fly   330 RNGSAGSGSSSKSGVIPKNRKSLRHSQQNLLDTEAAEVESAAAETGGEQQSEHGNLDVIDQLPTP 394
            |:|  |||:|:    |..:|.....||:::|..||....|.|:..   |.:...:::::|  |..
Mouse  2437 RDG--GSGNST----IIVSRSGEDESQEDVLMDEAPSNLSQASTL---QANREDSMNILD--PED 2490

  Fly   395 EAGPNQSEASGIHNQSQLEADRQPVVQDEDDEEDDEEEEEEEEEEVGFYGIVNSAGSSYEEDTQI 459
            |....|.|.|...|            :||||.:|:||||||:                 |||.| 
Mouse  2491 EEEHTQEEDSSGSN------------EDEDDSQDEEEEEEED-----------------EEDDQ- 2525

  Fly   460 VAEEDEITTEEEVDDEDDDEIEEEDLSE-------------SEFAQQLIGELGGERQQPQRATNN 511
              |:||   .||.|::|||:..|.:|.|             ..|.::  .:|..|......:..:
Mouse  2526 --EDDE---GEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDRE--DDLIIEFDNMFSSATD 2583

  Fly   512 AKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAPGAGGGGPRATRSSNSNSSNNVVD 576
            ...:..|.|               |:.....|.|.| .....|:|....|.|:....:...    
Mouse  2584 IPPSPGNIP---------------TTHPLMVRHADH-SSLTLGSGSSTTRLTQGIGRSQRT---- 2628

  Fly   577 YSIMPHLTTVATTTPHALTPQQHQQQRQPPQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFVTPT 641
                  |..:...|.|.:                |.....::|..||.:        |...:.|:
Mouse  2629 ------LRQLTANTGHTI----------------HVHYPGNRQPNPPLI--------LQRLLGPS 2663

  Fly   642 AAAAAAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHF 706
            |||.....::..|..|...|.........|........:..      .::|.......|      
Mouse  2664 AAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLD------DFFHDQSTATSQ------ 2716

  Fly   707 TSTGAGPPPALFQQQAPPQLTRYTPATAT---------TAATFVP-PQQQQVVYNPQQQQHSSLR 761
                ||...::     |..|||:|.....         .:...|| ....:.:.:.:.::....|
Mouse  2717 ----AGTLSSI-----PTALTRWTEECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKR 2772

  Fly   762 RSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAA--AVQQQL---LPPPGTYQYQQVGGNTVVVAV 821
            |....:..:.:.......::...|..|.:....  :.:|.:   .|.|.:  |.....:|.....
Mouse  2773 RKQLAEEETKIIDKGKEDKENRDQSAQCTVTKTNDSTEQNVSDGTPMPDS--YPTTPSSTDAPTS 2835

  Fly   822 RHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQHQQQQRATLVQPGFLFSYRSNQPQQQQ 886
            ..::.|...|..|||.|                             |..|..|    ...||:.|
Mouse  2836 ESKETLGTLQPSQQQPA-----------------------------LPPPPSL----GEIPQELQ 2867

  Fly   887 QPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPPHAGGQQITPGANSANLSIVAAALSAARDV 951
            .||::      |.:|:.....:....:....|||.......:::|.....:||...|..|.|...
Mouse  2868 SPAEE------VANSTQLLMPIELEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTA 2926

  Fly   952 GGGSDGGGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSNSNNVTATGSGSAPGGGPT 1016
            ......|.....::.|:.....:||:|.|.|:|..                 .|...|.||..|:
Mouse  2927 VSSQLEGSPMDTSSLASCTLEEAVGDTPAAGSSEQ-----------------PTAGSSTPGDAPS 2974

  Fly  1017 STGTTSGTQHGS---------GSGAAAAVDSESDDSEVGRLQALLEARGLPPHLFGALGPRVTHI 1072
            ......|....|         .|..|::..|.:.||.|....|  ::||               |
Mouse  2975 VVAEVQGRPDVSRESNQPPEDSSPPASSESSSTRDSAVAISGA--DSRG---------------I 3022

  Fly  1073 LHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGNEDTLAGFPIKQ-VVPALIQLLR 1136
            |...:.::||.:                               ||.|||..:.: |.|:.:..|.
Mouse  3023 LEEPLPSTSSEE-------------------------------EDPLAGISLPEGVDPSFLAALP 3056

  Fly  1137 MEHNFDIMNNACRALAYMLEALP--RSSGTVVEAVPVFLEKLQVIQCMDVAEQSLSAL------E 1193
            .:...:::.|       .|...|  ||:.:...:.|..:....|   .:|:.:.|:||      |
Mouse  3057 DDIRREVLQN-------QLGIRPPTRSAPSSNSSAPAVVGNPGV---TEVSPEFLAALPPAIQEE 3111

  Fly  1194 ILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFVAESLPLLARLLS 1258
            :|:::..:                     .||..||..|:....|.|..|   .::||...|...
Mouse  3112 VLAQQRAE---------------------QQRRELAQNASSDTPMDPVTF---IQTLPSDLRRSV 3152

  Fly  1259 QQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTAVVRMLSL 1323
            .:|.:                                   ..:|.|.|                 
Mouse  3153 LEDME-----------------------------------DSVLAVMP----------------- 3165

  Fly  1324 MCCSCPDLA--ISLLRNDIAATLLYL----LTGNAEPAAASATHVELISRSPSELYELTCLIGEL 1382
                 ||:|  ...||.:..|....|    |.|::..:|.||     |.|||:            
Mouse  3166 -----PDIAAEAQALRREQEARQRQLMHERLFGHSSTSALSA-----ILRSPA------------ 3208

  Fly  1383 MPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIEAANQSSEDEISLSTF 1447
                                                       ..|||  :.|:           
Mouse  3209 -------------------------------------------FTSRL--SGNR----------- 3217

  Fly  1448 GRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAAS 1512
            |..|               |...|||                    .|:...||:|         
Mouse  3218 GVQY---------------TRLAVQR--------------------GGTFQMGGSS--------- 3238

  Fly  1513 SNNNNNNNNNPPGNSVN-LNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSSAGPNV 1576
                  ::|.|.|::|: |.:::.|..||                                    
Mouse  3239 ------SHNRPSGSNVDTLLRLRGRLLLD------------------------------------ 3261

  Fly  1577 RYKCLRALLRMVYYATPEL----LRQVLK---YQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQ 1634
             ::.|..||.:::...|:|    |.:||:   |...:.|..       :|.::..||.:.     
Mouse  3262 -HEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWV-------IRSLLSILQRSS----- 3313

  Fly  1635 LPDVFGTHFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPF 1699
                                    .:.:|.. :|| ||     |:...|.:|:.:.|        
Mouse  3314 ------------------------ESELCIE-TPK-LS-----TSEERGKKSSKSCA-------- 3339

  Fly  1700 FMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTT-------AGG 1757
                            ||.|::..: ...|.|.:.:::.....|.::||.....|       :||
Mouse  3340 ----------------SSSHENRPL-DLLHKMESKSSNQLSWLSVSMDAALGCRTNIFQIQRSGG 3387

  Fly  1758 YNYSSSAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQP 1822
            ..::....||.|                .||....|  ||...:.:|.:.:     |:.:|.   
Mouse  3388 RKHTEKHASSGS----------------TVHIHPQA--APVVCRHVLDTLI-----QLAKVF--- 3426

  Fly  1823 HHQQPAHLVLASTSS---------GAASSSSSSSSSSSASALQHKMTDML--------KRKAPPK 1870
                |:|.....|..         |:..:.|..||.||:|.:.....|:|        .||....
Mouse  3427 ----PSHFTQQRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNS 3487

  Fly  1871 RKS---QSGGRAKSRQEDAAVAPAGS--GPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSG 1930
            .||   .|||..::.......:|.|.  .....|.....|.:.|.|.|..||.|    .:.|   
Mouse  3488 VKSVPVSSGGEGETSPHSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLIS----IALP--- 3545

  Fly  1931 GGSGSSKSRFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNS 1995
                .:|......||||:|||.::                                   :.|:::
Mouse  3546 ----ENKVSEVQTNSSNSGSSTAA-----------------------------------TSNTST 3571

  Fly  1996 TGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVK 2060
            |.:.:....|.|.:...|.:......|...|.:||.                             
Mouse  3572 TTTTTTTATAPTPTPPAATTPVTSAPALVAATAIST----------------------------- 3607

  Fly  2061 RYTEQEAKRSKAASESGATQSGSSGVGLSSTGNTPLSTA---GS---TNVLERLSSILFKLNGSY 2119
                             .|.:.|:.|...:|..|.:||:   ||   ..|.|..|.|.||     
Mouse  3608 -----------------ITVAASTTVTTPTTATTTVSTSTTKGSKSPAKVGEGGSGIDFK----- 3650

  Fly  2120 HDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEPL 2184
                         ::.|.::..::..|  ::.:.::..||.||  .||         |.:.|:..
Mouse  3651 -------------MVSSGLTENQLQLS--VEVLTSHSCSEEGL--EDA---------ANVLLQLS 3689

  Fly  2185 LQNVGQMPTIEPIAFGAFVAKLNGC----VTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLK 2245
            ..:.|...|:..:.       |||.    .|..:|....:             :.||.:|..|  
Mouse  3690 RGDSGTRDTVLKLL-------LNGARHLGYTLCKQIGTLL-------------AELREYNLEQ-- 3732

  Fly  2246 CNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLS 2310
               ||..||..|          .|..:.:...:...::|        ...|..||.:||..|   
Mouse  3733 ---QRRAQCETL----------SPDGLPEEQPQTTKLKG--------KMQSRFDMAENVVIV--- 3773

  Fly  2311 QASFRHKL-----------QFTIGDHVLPYNMTVYQAVKQFSP----LVSEQPETDNESETLLGN 2360
             ||.:..|           ..|.......:.:.|.|.:.|...    ...:..:|.....:.||:
Mouse  3774 -ASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGS 3837

  Fly  2361 AS---IWVQQHTIHYRPVEEEVTSGAAA----GAASSSSSCSS--GVQKQQS--SSSSASSCVNA 2414
            ||   ..|:|.......:.:.|..|..|    .||:|.||..|  .|::::|  .....|.....
Mouse  3838 ASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSNQSETSVRREESPMDVDQPSPSAQD 3902

  Fly  2415 TSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQD 2479
            |.|...|.|        |.:..|...:   |..||              |.||..|         
Mouse  3903 TQSIVISDG--------TPQGEKEKEE---KPPEL--------------PLLSEQL--------- 3933

  Fly  2480 ASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLPQWL 2544
             |||.|            ||.|..|:                  |...:..|...::.       
Mouse  3934 -SLDEL------------WDMLGECL------------------KELEESHDQHAVLV------- 3960

  Fly  2545 PQIGMACPFLFPFETRHLLFYATSFD--------RDRALQRLLDTTPDLNAAESSERVAPRLDR- 2600
                     |.|......|.:||..:        |:..|..:.|..|.|:.|..:......||. 
Mouse  3961 ---------LQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPF 4016

  Fly  2601 RKRAISRTEILKQAEHILQDF-----GHSKALLEIQYENEVGTGLGPTLEFYALVS--------- 2651
            ..|..|...|........|.|     .|...|.:|..::......||   |..||.         
Mouse  4017 FSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGP---FAVLVDYIRVLDFDV 4078

  Fly  2652 ------AELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHI------EDALEATTTDQNTPAV 2704
                  .||:|.|.||                  :.....:|:      ||:..           
Mouse  4079 KRKYFRQELERLDEGL------------------RKEDMAVHVRRDHVFEDSYR----------- 4114

  Fly  2705 AGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQF 2769
                             :.|:..|....:|.:::..|       .....||.......|:|::: 
Mouse  4115 -----------------ELHRKSPEEMKNRLYIVFEG-------EEGQDAGGLLREWYMIISRE- 4154

  Fly  2770 SDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQM 2834
                      :.||......|:.....|.|.|.|........||                     
Mouse  4155 ----------MFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSY--------------------- 4188

  Fly  2835 TKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDL 2899
                  |||:|:.:||||.|:|:|:..|:..||:.::.:  |:...|:..........||     
Mouse  4189 ------FKFVGRIVAKAVYDNRLLECYFTRSFYKHILGK--SVRYTDMESEDYHFYQGLV----- 4240

  Fly  2900 VRQREYIL-SDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLH 2963
                 |:| :|.:....:.|...|..:...|.:.||     .|..|||         .||..|..
Mouse  4241 -----YLLENDVSTLGYDLTFSTEVQEFGVCEVRDL-----KPNGANI---------LVTEENKK 4286

  Fly  2964 QYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQ 3028
            :|:.||....:...::||..|..|||..:.|.:.:.:|..:|||.:..|..:      .:|..|:
Mouse  4287 EYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT------IDIDDLK 4345

  Fly  3029 ESCRTDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDE 3093
            .:... |.:..:|..||:.:..|.|:::.::..|||||||:.::|..||.||.....|.:..:..
Mouse  4346 SNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHR 4409

  Fly  3094 NQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            :....|.|||..||.|.|.||.|.|.|.:|..|.:|..|.|..|.|:
Mouse  4410 DDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669 8/42 (19%)
WWE 1409..1481 CDD:128922 10/71 (14%)
FAM199X <1985..2074 CDD:292442 9/88 (10%)
HECTc <2818..3138 CDD:294058 87/320 (27%)
Huwe1XP_006528996.1 DUF908 92..367 CDD:399185
DUF913 431..892 CDD:399192
UBA_HUWE1 1395..1434 CDD:270474
WWE 1695..1756 CDD:397111
fibronec_FbpA <2809..>2992 CDD:411474 45/240 (19%)
DUF4414 3044..3071 CDD:405126 5/33 (15%)
DUF4414 3089..3120 CDD:405126 7/54 (13%)
HECTc 4101..4454 CDD:238033 107/458 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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