DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and HECW2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_006712709.1	Gene:	HECW2 / 57520	HGNCID:	29853	Length:	1579	Species:	Homo sapiens

Alignment Length:	1725	Identity:	322/1725 - (18%)
Similarity:	512/1725 - (29%)	Gaps:	635/1725 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1598 QVLKY----QLVSSHIAGMLGSNDLRIVVGALQMAEILMRQ---LPDVFGTHFRREGVIYQFTQL 1655
            |:|.|    :|.:.|::|.|   ..::.|.:....|:|...   .|:..||..   ||......|
Human   297 QMLSYNLGRRLPADHVSGYL---QFKVEVTSSVHEEMLFSHSDASPEAVGTIL---GVNSVNGDL 355

  Fly  1656 TDP-----------NNPICAN-PSPKPLSATATP---------------TANAGGSQSAPASANS 1693
            ..|           ::.:|:| |..:..:|..||               ...:..|:::|.....
Human   356 GSPSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQ 420

  Fly  1694 LQVNPFFMD-------SAPG---LSSASTTPSSSKHQSYSVKSFSHAMNALTASAK--------G 1740
            ..:|. ::|       |.||   .|..|...|.....|:...:..:||..:.:..:        |
Human   421 DSLND-YLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLG 484

  Fly  1741 TPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAY-------FVTQQGDPRQYVHFQQPAVPAPP 1798
            .|       ||....||....|.|..:..|:..:.       ...::....:...|:......|.
Human   485 YP-------SSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPE 542

  Fly  1799 PQQELLPSG-VQQQGQQVPQVIYQPHHQQPAHLVLAS-----TSSGAASSSSSSSSSSSASALQH 1857
            ..:..||:| ..::|:..|:.  ||...|.:..:..|     .:|||.:.:|.:|..|..:..:
Human   543 LAESSLPAGPAPEEGEGGPEP--QPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSE- 604

  Fly  1858 KMTDMLKRKAPPKR-KSQSGGRAKSRQEDAAVAPAGSGPGG------APPSSSGSAMHELLSRAT 1915
              |:.|.:.:.|.: .|::.....:|.|  :|:.|.:.|.|      |..|.:.|...:|.|..|
Human   605 --TESLDQGSEPSQVSSETEPSDPARTE--SVSEASTRPEGESDLECADSSCNESVTTQLSSVDT 665

  Fly  1916 SLGSGNGGR--STP-----------------NSGGGSGSSKSRFNAG--------NSSNAGSSKS 1953
            ...|....|  .||                 :||...||.:|...||        :..:.|....
Human   666 RCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGPGAE 730

  Fly  1954 SFLASLNPAR-----WGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGA 2013
            |  |::....     |.|:..........:|..|..|         |.|...|.....|..:.||
Human   731 S--ATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEG---------SAGEAQGTCEGATAQEEGA 784

  Fly  2014 --GSGAGGLNAAAVAASISKSI-------------------SHANLLAAANRERARQWVREQAVD 2057
              ||.|.|........|:.:.:                   ||..:....:..|...|.|..|..
Human   785 TGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPP 849

  Fly  2058 FVKRYTEQEAKRSKAASESGATQSGSSGVGLSSTGNTP------LSTAGSTNVLERLSSILFKLN 2116
                 ..|..:||.:..:..........:..:.|...|      :..||......:.|:...:.|
Human   850 -----APQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRREN 909

  Fly  2117 GSYHDCLDALLELKTILLESD-----ISP--FEVNHSG-----------LIKAMLNYMTSETGLV 2163
            ...|....:.:   |:||:|.     |||  |.|.||.           .:|.|:..:..:|...
Human   910 ILPHSTSRSRI---TLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHF 971

  Fly  2164 ER---DARLRSFMHVFAGLPLEPLLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPA 2225
            ||   :..|..|:::||...||                                        .|.
Human   972 ERYQHNRDLVGFLNMFANKQLE----------------------------------------LPR 996

  Fly  2226 GPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQA-------IERYLVVR 2283
            |...:.:.....||..|..:.                 |..|||...:|:       :.|..:.|
Human   997 GWEMKHDHQGKAFFVDHNSRT-----------------TTFIDPRLPLQSSRPTSALVHRQHLTR 1044

  Fly  2284 GYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVK--QFSPLVSE 2346
            .    |:.|..:..||.              ||     .|..|||...:.:..|.  |:..:|
Human  1045 Q----RSHSAGEVGEDS--------------RH-----AGPPVLPRPSSTFNTVSRPQYQDMV-- 1084

  Fly  2347 QPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSC 2411
             |...|:      ....:::|..|.      |:                  :|::|.
Human  1085 -PVAYND------KIVAFLRQPNIF------EI------------------LQERQP-------- 1110

  Fly  2412 VNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVT 2476
                              .||:. |....|....:||                    ..|..|..
Human  1111 ------------------DLTRN-HSLREKIQFIRTE--------------------GTPGLVRL 1136

  Fly  2477 VQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLP 2541
            ..||.|..|..|.....:              :.:|....:||.       ..|.|......: |
Human  1137 SSDADLVMLLSLFEEEIM--------------SYVPPHALLHPS-------YCQSPRGSPVSS-P 1179

  Fly  2542 QWLPQIGMA-----CPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRR 2601
            |..|....|     .|:...||.:...||           |.|:|        ......|
Human  1180 QNSPGTQRANARAPAPYKRDFEAKLRNFY-----------RKLET--------KGYGQGP----- 1220

  Fly  2602 KRAISRTEILKQAEHILQD-----FGHSKALLE-----IQYENEVGTGL-GPTLEFYALVSAELQ 2655
                .:.:::.:.:|:|:|     .|:|:..|:     :.:..|.|... ||:.||:.|||.||.
Human  1221 ----GKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELF 1281

  Fly  2656 RTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTT 2720
            ....||:    .|..|....|.:
Human  1282 NPYYGLF----EYSANDTYTVQI------------------------------------------ 1300

  Fly  2721 AQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSS 2785
                                                                 |...|.:||
Human  1301 -----------------------------------------------------SPMSAFVDN--- 1309

  Fly  2786 TTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAK 2850
                     |:..                                          |:|.|:.:..
Human  1310 ---------HHEW------------------------------------------FRFSGRILGL 1323

  Fly  2851 AVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAM 2915
            |::...:||..|:.|||:            .|:|:       |..|.||    ||:
Human  1324 ALIHQYLLDAFFTRPFYK------------ALLRI-------LCDLSDL----EYL--------- 1356

  Fly  2916 EKTEKIEQ-----LDLDGCPIADLGL---DFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYW 2972
              .|:..|     .|.|...|.||..   :.|.......||..||.:.|||..|..:||..:..|
Human  1357 --DEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKW 1419

  Fly  2973 FLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGF 3037
            .:..||.:|.|:|..||..|...:.:.:|...|||.|..|: :|...|.|     :.:.....|:
Human  1420 RIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGT-AEIDLSDW-----RNNTEYRGGY 1478

  Fly  3038 HQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL---TPPLTIVRKTLDENQNPND 3099
            |.:...|::.:..:..:|.:::...||||||:..:|..||.:|   ..|    |:...|......
Human  1479 HDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGP----RRFCVEKWGKIT 1539

  Fly  3100 YLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGS 3134
            .||...||.|.|.||.|.|..::.:||..|..|.|
Human  1540 ALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETS 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	21/109 (19%)
		HECTc	<2818..3138	CDD:294058	86/328 (26%)
HECW2	XP_006712709.1	HECW_N	45..164	CDD:318711
		C2_NEDL1-like	185..321	CDD:176073	7/26 (27%)
		NESP55	<471..638	CDD:115071	34/180 (19%)
		PHA03169	591..>801	CDD:223003	48/225 (21%)
		WW	816..845	CDD:306827	4/28 (14%)
		WW	994..1023	CDD:306827	7/45 (16%)
		HECTc	1223..1577	CDD:238033	113/549 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900