DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and hace1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_701235.5	Gene:	hace1 / 572430	ZFINID:	ZDB-GENE-110411-52	Length:	905	Species:	Danio rerio

Alignment Length:	1134	Identity:	211/1134 - (18%)
Similarity:	374/1134 - (32%)	Gaps:	418/1134 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  2139 SPFEVNHS-GLIKAMLNYMTSETGLVE-------RDARLRSFMHVFAGLPLEPLLQNVGQMPTIE 2195
            |.|:||:: |.:|..|.::.:..|.||       |.|. .::..:....||....:| ||...:.
Zfish    58 SKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKRGAN-PNYQDISGCTPLHLAARN-GQKKCMG 120

  Fly  2196 PIAFGAFVAKLNGC----VTQLEQFPVK-----VHDF-----PAGPGGRSNQSALRFF--NTHQ- 2243
            .:.  .:.|.:|.|    :|.:....|.     :||.     .........|:||...  |.|:
Zfish   121 RLL--EYNADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKT 183

  Fly  2244 -LKCNLQRHPQCN--NLRQWKGGTVKIDPL-----------AMVQAIE--RYL------------ 2280
             ::|.|......|  |:   .|.|    ||           |.:..:.  :||
Zfish   184 TVQCLLDSGADINRPNV---SGAT----PLYFACSHGQRDTAQILLLRGAKYLPDRNGVTPLDLC 241

  Fly  2281 VVRGYGG----------------IRADSDDDSEEDM------------DDNVAAVVLSQASFR-- 2315
            |..|||.                |:...:||.:|:|            |.|...::.|.|...
Zfish   242 VQGGYGETCEILIQHHGRLFQTLIQMTQNDDIKENMLRQVLEHVSQQNDSNYQRILTSLAEVATT 306

  Fly  2316 --HKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNAS-------------IWV 2365
              ||| .::..:......::.:.::.|..:....|.:.|....:..|.:             :|
Zfish   307 NGHKL-LSLSSNFEVQTKSLLRIIRIFCHVFCLGPSSPNNGNDMGYNGNKTPRSQVFKPLELLW- 369

  Fly  2366 QQHTIH------YRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASS-----CVNATSSCS 2419
              |::.      ...:|:|:|.   ...:||.:..:|...|:|....|.||     .::|:|...
Zfish   370 --HSLDEWLVLISTELEKEITD---TTRSSSGNDIASLFLKKQEVDHSVSSENPQLLLDASSVMK 429

  Fly  2420 SSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDA 2484
            :....|.|...::..|::.|:                 ||.|.....|..:|..:.:.
Zfish   430 TPEVYADGQDVISMIANRLSA-----------------VIQAFYMCCSCQMPHGMTSP------- 470

  Fly  2485 LCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIH-------PKIMAKANRQLQDPLVIMTGNLPQ 2542
                |.|..:.:| |.:..|.|.:|  |:..|.|       |::|::.       :.|:.|.
Zfish   471 ----RFIEFVCKH-DEVLKCFVTRN--PKIIFNHFHFLLECPELMSRF-------MHIIKGQ--- 518

  Fly  2543 WLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERV-APRLDRRKRAIS 2606
                         ||:.|...||          :.||...||      |:.| .|..:.....:.
Zfish   519 -------------PFKDRCEWFY----------EHLLAGQPD------SDMVHRPVNENDILLVH 554

  Fly  2607 RTEILKQAEHILQDFGHSKAL--LEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSDSYK 2669
            |..:.:.:..::....:.|..  :.:::..|.|.|.|...|::.::|.|:...|..|:..|
Zfish   555 RDSLFRSSCEVVSKSSNEKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIINPDYALFTQS---- 615

  Fly  2670 QNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSR 2734
                                  .:.||...|
Zfish   616 ----------------------ADGTTFQPN---------------------------------- 624

  Fly  2735 SHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTT 2799
                             |::..|.:.||.
Zfish   625 -----------------SNSSVNPDHLNY------------------------------------ 636

  Fly  2800 NNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSL 2864
                                                     |:|.|:.:..|:...:::::.|:.
Zfish   637 -----------------------------------------FRFAGQILGLALYHRQLVNIYFTR 660

  Fly  2865 PFYRWLVSEEHSIGL----ADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLD 2925
            .||:      |.:|:    .|:..:.||....|          ::||.:
Zfish   661 SFYK------HILGIPVSYQDVSSIDPEYAKNL----------QWILDN---------------- 693

  Fly  2926 LDGCPIADLGLDF-------VLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFE 2983
                .|:||||:.       |......:.|..||....||..|..:|:.|||...:...:|.|..
Zfish   694 ----DISDLGLELTFSVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQIN 754

  Fly  2984 ALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH--GFHQDSQAIQY 3046
            |..:||.:..|...:::|...|||.:..|..        ||.::.....|::  |:......||:
Zfish   755 AFLQGFHTFIPPSLIQLFDEYELELLLSGMP--------EIDVMDWKRNTEYTSGYDLQEPVIQW 811

  Fly  3047 LYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYL 3111
            .:|::.:..::|:...|||||||.|:|.|||..|.....:.:.|:......::.||:..||:|.|
Zfish   812 FWEVVENLTQEERVLLLQFVTGSSRVPHGGFAFLMGGSGLQKFTVAAVPYTSNLLPTSSTCINML 876

  Fly  3112 KLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            |||:|.|::|:|.:|.||.:.||..:.::
Zfish   877 KLPEYPSKDVLRDRLLVALHCGSYGYTMA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	82/332 (25%)
hace1	XP_701235.5	ANK repeat	71..100	CDD:293786	6/29 (21%)
		ANK	71..98	CDD:197603	6/27 (22%)
		Ank_2	74..199	CDD:289560	25/128 (20%)
		ANK	97..222	CDD:238125	26/134 (19%)
		ANK repeat	102..133	CDD:293786	7/33 (21%)
		ANK repeat	135..166	CDD:293786	4/30 (13%)
		Ank_2	140..227	CDD:289560	17/93 (18%)
		ANK repeat	168..199	CDD:293786	8/30 (27%)
		ANK repeat	201..226	CDD:293786	5/28 (18%)
		Ank_4	204..254	CDD:290365	10/53 (19%)
		ANK repeat	233..261	CDD:293786	4/27 (15%)
		HECTc	550..899	CDD:238033	99/546 (18%)
		HECTc	575..898	CDD:214523	97/520 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000