DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and plekha7a

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001129715.1	Gene:	plekha7a / 571486	ZFINID:	ZDB-GENE-050419-75	Length:	1197	Species:	Danio rerio

Alignment Length:	1149	Identity:	206/1149 - (17%)
Similarity:	349/1149 - (30%)	Gaps:	391/1149 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 FAQQLIGELGGE------RQQPQRATNNAKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHG 548
            |...:.|::..|      :.||     ..:..|..:..::.|||...|:|..::||
Zfish    81 FIHPVTGQISTENSDFRLQDQP-----GGRMLKQPSSTISEASTTVTTSTVDSTSG--------- 131

  Fly   549 QGAAPGAGGGGPRATRSSNSNSSNNVVDYSIMPHLTTVATTTPHALTPQQHQQQRQPPQPPSHQQ 613
                            |..|.||..|                 |:...:.|..:|.|. |...:.
Zfish   132 ----------------SKGSRSSGRV-----------------HSFGKRDHAIKRNPSXPVVVRG 163

  Fly   614 QQVHQQQQPPQLLPTHQF----------------AHLSSFVTPTAAAAAAAAAAHYPPASAAAA- 661
            ....|.....:|.....|                :.|.|...|:...|......|.....|..|
Zfish   164 WLYKQDSSGMRLWKRKWFVLADFCLFYYKDSREESVLGSIPLPSYTIAPVGPEDHISRKYAFKAE 228

  Fly   662 -------YF------------------AQQQHH--------QHQHQHQQQHVQQAQAPQPHYYHS 693
                   ||                  |..|.|        ...|.:..:.:::...||.::.:|
Zfish   229 HTGMRTYYFSADTQEDMNGWVRAMNQAALMQTHTVKRDECGHPDHVNVSEKLKKQAVPQTNHINS 293

  Fly   694 SVAVLHQPPPHHFTSTG-------------------------AGPPPA--------LFQQQAPPQ 725
            .|.    |.|....|.|                         .|..||        |.....||.
Zfish   294 YVI----PKPEVIQSDGLPEDKREGFVGEVEIQVTPREMEQARGKSPASRVVEVEVLAPGSTPPS 354

  Fly   726 LTRYTPATATTAATFVPPQQQQVVYNPQQQQHSSLRRSSRGKTGSC--------------VSSAA 776
               ...:.|.:.|...||..|:   |....:.:.:....||.|.|.              |.:..
Zfish   355 ---RVASRAPSRAVSTPPVVQR---NGTPIEQNGMPGCQRGATPSAQTPVQVQRRSTLEQVENWV 413

  Fly   777 AAQQQQHHQQQQHSSAAAAVQQQLLPPPGTY-QYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALH 840
            ..|:::.|......|........:.|..||. :||.:                .:..:|...|.|
Zfish   414 KVQKEERHGLVSTESTVPRRTPPIHPKYGTMDKYQSL----------------PKTSRQSPPAPH 462

  Fly   841 HQ-HQQQQHQQQQQQHQQQQHQQQQRATLVQPGF--LFSYRSNQPQQQQQPAQQIHQGPKVTHSS 902
            || ..:.::...:..|.|:.|...:|.|......  ||.::..|..:...|...::. |...:|:
Zfish   463 HQLPSEYKYSHDRLNHFQKIHGHTKRPTTHDNTVWQLFEWQQRQQFRHGSPFAPVYT-PAPDYST 526

  Fly   903 AASDA-----LTYSL-----MAQQPPSGPPHAGGQQITPGANSANLSIVAAALSAARDVGGGSDG 957
            |.|..     ::.|:     :|..||.|||  |.:.::|....
Zfish   527 AVSSTRNNPDVSRSVSVPPTLADIPPPGPP--GARLMSPRRPH---------------------- 567

  Fly   958 GGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTS 1022
                   |||...:...:.:...|           :...|||.:
Zfish   568 -------TPAERVTVRPLEDRPIV-----------EVPPSNSPH--------------------- 593

  Fly  1023 GTQHGSGSGAAAAVDSESDDSEVGRLQ----ALLEARGLPPHLFGALGPRVTHILHRTIGNSSSS 1083
                                    ||:    |.:|.|.:||..:      :||    |:...|
Zfish   594 ------------------------RLRSYKSATIERRSMPPSAY------ITH----TVSAPS-- 622

  Fly  1084 KANQLLQGLQSHDESQQLQAAIEMCQMLVMGNEDTLAGFPIKQVVPALIQLLRMEHNFDI-MNNA 1147
                 |:|..:.|....|:..:|...:.|.|.| .|.|.|.|.|..|       |.:.|: ::..
Zfish   623 -----LRGKTADDTYMHLKKGLEYLDLKVSGTE-ALKGRPAKPVKVA-------ESDVDVTLSRL 674

  Fly  1148 CRALAYMLEALPRSSGTVVEAVPVFLEKLQVIQCMDVAEQSLSALEILSRRHNKAILQANGISAC 1212
            |.....:.|...|.||...:.     :||:.:  :||:.|.:...:......:|...|...:...
Zfish   675 CEQDKILQELEFRLSGLKDDK-----DKLESV--LDVSHQQMEQYKDQPSHTDKIAYQQRLLQED 732

  Fly  1213 LTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFVAESLPLLARLLSQQDKKC------------- 1264
            |.::        ||.:: ..:..:....:::..:.:|:..|..:|..|...|
Zfish   733 LVHI--------RADIS-RVSTEMERAWDDYSGMEQSVEQLRDVLQTQMTLCTSPQEKNQLKREL 788

  Fly  1265 --IESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTAVVRMLSLMCCS 1327
              :|.|.:......|:|:         .:.|.:||.::.|:  |:::.:   |...|      |.
Zfish   789 WRMEDVMTGLSSTKETFK---------ITVDSVKNPERKLV--PSVIES---TVPSR------CM 833

  Fly  1328 CPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSELYELTCLIGELMPRLPLDGIF 1392
            .|..|      ::.:....|   .:.|.:....:.:|.:|.|...:|    ..:..||.||..::
Zfish   834 TPSAA------EVRSPQRSL---TSSPLSLPLDNEDLRNRHPVPNWE----EDDAPPRPPLPLLY 885

  Fly  1393 AVDSLLDRPTLNTQDQV--HWQWRD----------DRGSWHNYSTIDSRLIEAANQSSEDEISLS 1445
            ..|:....|.|..:..|  |...|.          ||.|  :||..|.|| |..:..||.|:.:|
Zfish   886 DEDTPPVVPPLPKETSVIRHTSVRGLKRQSDERKRDRES--SYSNGDYRL-ELRSYLSEPELPVS 947

  Fly  1446 TFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDL 1489
            ..|..:....:...|....:|::    .|:|...||..|..:||
Zfish   948 AHGADHVDPGYLTLQRRGLSGSS----SRINQYGVASCSLRRDL 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	12/75 (16%)
		WWE	1409..1481	CDD:128922	21/83 (25%)
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
plekha7a	NP_001129715.1	WW	55..84	CDD:278809	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..148		16/96 (17%)
		PH_PEPP1_2_3	153..256	CDD:270068	15/102 (15%)
		PH	159..255	CDD:278594	12/95 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..384		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..467		11/59 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..577		17/100 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..928		24/118 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1064
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900