DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and trip12

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	2692	Identity:	1023/2692 - (38%)
Similarity:	1389/2692 - (51%)	Gaps:	660/2692 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 AQQLIGELGGERQQPQRATNNAKKTKNNTPAVAAASTIKATTTATTSSGYQQR-----------A 544
            ||.:...|.| |.||::....|.....|..:.:.||....::....:.|:..|           :
Zfish    23 AQPIDHTLAG-RLQPEQVNQKANSPPENRRSNSKASKAPPSSAVGYARGHTSRRNSLSLSVGSLS 86

  Fly   545 APHGQGAAPGAG-------GGGPRATRSSNSNSSNNVVDYSIMPHLTTVATTTPHALTPQQHQQQ 602
            .|.....|.|..       |...||.:.|:.:..|  :.:|..|      ...|..::.......
Zfish    87 IPDPDLEAAGTSGQQGRREGSSTRALKRSSVSEPN--ITFSPSP------AKRPKVVSSHFSDSS 143

  Fly   603 RQPPQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQ 667
            ...|..|:...:....::.|..:....:...|::  .|..|.|.:..::.||..|.|::..:|::
Zfish   144 ASGPSAPAISPEVTEPRKAPASVSTKSKKRRLAA--EPAPARALSKKSSSYPGPSGASSTPSQKR 206

  Fly   668 HHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTGAGP-PPALFQQQA--PPQLTRY 729
                         ::|.|.    ..||.:....|.    :|:.||| ||.....:|  |.:|...
Zfish   207 -------------KKADAT----LLSSSSSSSLPS----SSSAAGPLPPRSEASRAAKPTKLASK 250

  Fly   730 TPATATTAATFVPPQQQQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAA 794
            :.|:|....:.|......   :......||...|:...|.||....|..:|.:...:.:.|.:|:
Zfish   251 SAASAKAGCSTVTDSSSS---SASSSSSSSSSSSAATGTNSCAPQGARLKQGKDQSKARRSRSAS 312

  Fly   795 AVQQQLLPPP-----GTYQYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQ 854
            :      |.|     ...|.:..|.:....|.|...::...:.:
Zfish   313 S------PSPRRSSRDKEQSKAAGSSKFDWASRFNSKVNLPKPK--------------------- 350

  Fly   855 HQQQQHQQQQRATLVQPGFLFSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPS 919
                         |..||...:..|::|            ||....:..||...:....::.||:
Zfish   351 -------------LSLPGSAKAETSSKP------------GPSGLQAKLASLRKSTKKRSESPPA 390

  Fly   920 GPP--HAGGQQITPGANSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVG 982
            ..|  ....:|.|.|         :.|.::.|..|.|..|...|    ......|.|..|.....
Zfish   391 ELPSCRRSTRQKTTG---------SCASTSRRGSGLGKRGAAEA----RRQEKMADSDNNQDGAN 442

  Fly   983 ASSSSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSESDDSEVGR 1047
            :|::......|.||::|:...|.|.            ||||             :|||||||:||
Zfish   443 SSAARTEETPQGASASSSVAGAVGM------------TTSG-------------ESESDDSEMGR 482

  Fly  1048 LQALLEARGLPPHLFGALGPRVTHILHRTIGNSSSSKANQLLQGLQ-SHDESQQLQAAIEMCQML 1111
            ||||||||||||||||..|||::.:.|||||:.:||||.||||||| :.||||||||||||||:|
Zfish   483 LQALLEARGLPPHLFGPFGPRMSQLFHRTIGSGASSKAQQLLQGLQATGDESQQLQAAIEMCQLL 547

  Fly  1112 VMGNEDTLAGFPIKQVVPALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVEAVPVFLEKL 1176
            |||||:||.|||:|.||||||.||:|||||||||:|.|||.||:|||||||..||:|:|||||||
Zfish   548 VMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHASRALTYMMEALPRSSAVVVDAIPVFLEKL 612

  Fly  1177 QVIQCMDVAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPE 1241
            ||||.:|||||:|:|||:|||||:||||||.|::.||.||:||||.|||.|||||||||.::.|:
Zfish   613 QVIQFIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPD 677

  Fly  1242 EFHFVAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTP 1306
            ||||||:|||||.:.|:.||||.:||.|..|.|||::|||:...|||:||.|||.|.||||::||
Zfish   678 EFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASRDLLTNIQQLLVLTP 742

  Fly  1307 AILNTGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSE 1371
            .:|::|.|..||||.||||.:||.||:.|::.:||.||.:||.|.:.  .:....::|:.|||.|
Zfish   743 PVLSSGMFIMVVRMFSLMCSNCPCLAVQLMKQNIAETLRFLLCGASN--GSCQEQIDLVPRSPQE 805

  Fly  1372 LYELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIEAANQ 1436
            |||||.||.||||.||.:||||||::|.:.:..|.:...||||||||.||.|:.||||:||.|:|
Zfish   806 LYELTSLICELMPCLPREGIFAVDAMLKKGSAQTTEGAIWQWRDDRGLWHPYNRIDSRIIETAHQ 870

  Fly  1437 SSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGG 1501
            :.||||||||.||.||:||::||||||||||.|.:||:.|     |::
Zfish   871 NGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPN-----PLA----------------- 913

  Fly  1502 ASTSAAAAAASSNNNNNNNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYE 1566
                              |.|..|:.    :|:|.   |||...:||:..||..|||.:|.||||
Zfish   914 ------------------NPNTGGHL----EVRRE---DARAQLMKEDPELAKCFIKTLFGVLYE 953

  Fly  1567 VYSSSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEIL 1631
            ||||||||.||:|||||:||::|:|..|||:.||:...||||||.||.|.||:||||:|||||||
Zfish   954 VYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLRNHAVSSHIASMLSSQDLKIVVGSLQMAEIL 1018

  Fly  1632 MRQLPDVFGTHFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQV 1696
            |::|||||..:||||||::|...|.:           ..:..|:.|.|...|:.|...:.
Zfish  1019 MQKLPDVFSVYFRREGVMHQVKNLAE-----------SEVFLTSPPKACTSGTASLCTTT----- 1067

  Fly  1697 NPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYS 1761
                      :::|:||.:|:........||.|:|:           .:||
Zfish  1068 ----------ITTATTTAASNVTPDLGSPSFQHSMD-----------DSLD-------------- 1097

  Fly  1762 SSAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQ 1826
                                                     |.|.|
Zfish  1098 -----------------------------------------LSPQG------------------- 1102

  Fly  1827 PAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPA 1891
                                           :::|:||||..|||    |.|.
Zfish  1103 -------------------------------RLSDVLKRKRLPKR----GPRR------------ 1120

  Fly  1892 GSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFL 1956
               |..:||.......::..|..|:                                .|.|||||
Zfish  1121 ---PKYSPPRDDDKVDNQAKSPTTT--------------------------------QSPKSSFL 1150

  Fly  1957 ASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLN 2021
            |||||..||:.                 |...:|.||..:.:...:|||....:
Zfish  1151 ASLNPKTWGKL-----------------GTQANSANSEPSRTAGVSGLARVPPK----------- 1187

  Fly  2022 AAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSSGV 2086
                     .|:|:       ||::.:.|::|||..||:||...|
Zfish  1188 ---------DSVSN-------NRDKIKAWIKEQASKFVERYFNSE-------------------- 1216

  Fly  2087 GLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKA 2151
              |..|:.|     :.|||:||.:...:||......::.|.|:.:|:.|||:|.||:.||||:|.
Zfish  1217 --SVDGSNP-----ALNVLQRLCTATEQLNLQMDSGVECLEEISSIVSESDVSSFEIQHSGLVKQ 1274

  Fly  2152 MLNYMT--SETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMP--TIEPIAFG---AFVAKLNGC 2209
            :|.|:|  ||...:.||.|::.|:|||.|.|:.      ||.|  .::|...|   |.|.|:|.|
Zfish  1275 LLLYLTSNSERDTISRDERIKRFLHVFFGCPIP------GQEPPGRLDPTENGPLLALVHKMNNC 1333

  Fly  2210 VTQLEQFPVKVHDFPAGPG-GRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMV 2273
            ::|:|||||||||||:|.| |.....||:|||||||||.|||||.|.|::|||||.|||||||:|
Zfish  1334 LSQMEQFPVKVHDFPSGNGNGSRGSQALKFFNTHQLKCQLQRHPDCTNVKQWKGGPVKIDPLALV 1398

  Fly  2274 QAIERYLVVRGYGGIR---ADSDDD-SEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVY 2334
            |||||||||||||.||   .||||| |::::|:::||..|:..|.||:|||.||:|:||||||||
Zfish  1399 QAIERYLVVRGYGRIREEDEDSDDDGSDDEIDESLAAQFLNSGSVRHRLQFYIGEHLLPYNMTVY 1463

  Fly  2335 QAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQ 2399
            |||:|||....|:.|:.::....||.|.||.:.||:.|:||.|:            ...|...|.
Zfish  1464 QAVRQFSLQAEEERESTDDEANPLGRAGIWTKTHTVWYKPVRED------------EEGCKDAVG 1516

  Fly  2400 KQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKP 2464
            .::..:.:|.:                          |:|.:..:|:.||||||:.|.|.:.|:.
Zfish  1517 GKRGRAQTAPT--------------------------KTSPRNAKKQDELWHEGVCPSVANPLET 1555

  Fly  2465 FLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQL 2529
            :|... |.:.:|..|.|::.:.:|||:|:::|:|.:||.....:.|||..:||:.|:.|||||||
Zfish  1556 YLICD-PPEGITFDDPSMEVILLLRVLHSISRYWFYLYDNAACKEIIPTGEFINSKLTAKANRQL 1619

  Fly  2530 QDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSE-R 2593
            ||||||||||:|.||.::|..|||.|||:||.:|||.|:||||||:||||||.|::|.::|.: |
Zfish  1620 QDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSR 1684

  Fly  2594 VAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTD 2658
            |||||||:||.|:|.|:|||||.::||.|.|:|:||||||||||||||||.|||||||.||||.|
Zfish  1685 VAPRLDRKKRTINRDELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTQEFYALVSQELQRAD 1749

  Fly  2659 LGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQ 2723
            ||||.|.:      ||:
Zfish  1750 LGLWRGEE------VTL------------------------------------------------ 1760

  Fly  2724 HQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTT 2788
                                      |:...|:.|.
Zfish  1761 --------------------------SNPKVGSQEG----------------------------- 1770

  Fly  2789 ATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVM 2853
                                  |.|:.:..|||.:|.|:::|...:.|.|.||:||||.||||:|
Zfish  1771 ----------------------TKYMFSSRGLFAVPFGRTTKPAHIAKIKMKFRFLGKLMAKAIM 1813

  Fly  2854 DSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKT 2918
            |.|:||||..||||:|::..|.||...||:.:.|.|..::..|:|::||::.|..|.:.......
Zfish  1814 DFRLLDLPLGLPFYKWMLRHESSISSHDLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQ 1878

  Fly  2919 EKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFE 2983
            :.:|.|:::||.:.||||||.|||..||||.:||:|.|||:|||..|:.||.||.|.|||.:|||
Zfish  1879 QALESLNMNGCSVEDLGLDFTLPGFPNIELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFE 1943

  Fly  2984 ALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLY 3048
            :.||||:||||:..|:.||||||:.:.|||.||.    |::|.|.|.||.|||:..||:|:::|:
Zfish  1944 SFREGFESVFPLHHLQYFYPEELDQLLCGSKSES----WDVKTLMECCRPDHGYTHDSRAVRFLF 2004

  Fly  3049 EILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKL 3113
            |:|:|::.::||.||||||||||||.|||::|.|||||||||.:..:||:|:|||||||||||||
Zfish  2005 EVLSSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 2069

  Fly  3114 PDYSSREVMRQKLKVAANEGSMSFHLS 3140
            |||||.|:||:||.:||.||..|||||
Zfish  2070 PDYSSIEIMREKLLIAAREGQQSFHLS 2096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	12/45 (27%)
		WWE	1409..1481	CDD:128922	47/71 (66%)
		FAM199X	<1985..2074	CDD:292442	20/88 (23%)
		HECTc	<2818..3138	CDD:294058	175/319 (55%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915	44/64 (69%)
		HECTc	1693..2094	CDD:238033	230/535 (43%)
		HECTc	1711..2090	CDD:214523	217/513 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I762
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1633	1.000	Inparanoid score	I76
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	1	1.000	-	-		FOG0004709
OrthoInspector	1	1.000	-	-		oto39886
orthoMCL	1	0.900	-	-		OOG6_102181
Panther	1	1.100	-	-	LDO	PTHR45670
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3704
SonicParanoid	1	1.000	-	-		X3310
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.950