DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and smurf2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	299	Identity:	89/299 - (29%)
Similarity:	139/299 - (46%)	Gaps:	47/299 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  2841 FKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREY 2905
            |.|:|:.|..||.....:|..|:||||:.|:.:  .|.|.|:..|.|::.|:||          :
Zfish   500 FHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK--PITLDDMESVDPDLHNSLV----------W 552

  Fly  2906 ILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANI---ELCRGGRDTPVTVHNLHQYIS 2967
            ||.:.....::.|..:|.                 ..:..|   ||...|:..|||.....:|:.
Zfish   553 ILDNDITGVLDHTFCVEH-----------------NAYGEIIQHELKPNGKSIPVTQDTKKEYVR 600

  Fly  2968 LVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCR 3032
            |...|..:.|::.||.||::||:.|.|...|:.|..:|||.:.||.|      :.:|...:.:.|
Zfish   601 LYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLG------KIDINDWKSNTR 659

  Fly  3033 TDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALT----PPLTIVRKTLDE 3093
            ..| ...||..:::.:..:.||:.:.:...|||||||.|:|..|||||.    |.|..:.: :|.
Zfish   660 LKH-CTPDSNIVKWFWRAVESYDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQ-IDA 722

  Fly  3094 NQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANE 3132
            :.|   .||...||.|.:.:|.|.|.:.:..||..|..|
Zfish   723 STN---NLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEE 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	89/299 (30%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736
		WW	298..330	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375
		HECTc	410..762	CDD:238033	89/299 (30%)
		HECTc	437..762	CDD:214523	89/299 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900