DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and hectd2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_009304826.1	Gene:	hectd2 / 562999	ZFINID:	ZDB-GENE-100405-3	Length:	756	Species:	Danio rerio

Alignment Length:	343	Identity:	88/343 - (25%)
Similarity:	153/343 - (44%)	Gaps:	68/343 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  2815 HAVHGLFPLPLGKSSKLPQMTKAK----AKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSE-- 2873
            |..:|:|...  |.|:....:..|    ::|:.:|..|..||.:|..||:.|....|:.|::.
Zfish   454 HTDYGMFTYV--KESQCYWFSSWKCDNYSEFRLVGALMGLAVYNSITLDIRFPPCVYKKLLTPPI 516

  Fly  2874 -----EHSIGLA-----DLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDA-MEKTEKIEQLDLD 2927
                 :..:|:|     ||.::.|::.:.|         .|.:..:.|::. ...|.::.|.:|.
Zfish   517 VPCDLDTPVGMATLTLDDLQQIMPDLAHGL---------GELLSYEGNVEEDFYTTFQVFQEELG 572

  Fly  2928 GCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSV 2992
                       |:..:   .|..||...|||..|..:|:.|...:.|.:.:.:||.|...||.||
Zfish   573 -----------VVKAY---NLKPGGDKIPVTNLNRKEYVQLYIDFLLNKSIYRQFAAFYHGFHSV 623

  Fly  2993 FPIQRLRMFYPEELECVFCGS-----GSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILA 3052
            .....|.:..|||:|.:.|||     ||.|:..::|            |:.:....|:..::::.
Zfish   624 CASNALMLLRPEEVEILVCGSPNLDMGSLQRVVQYE------------GYSKTDPTIRAFWDVVL 676

  Fly  3053 SYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYS 3117
            ::..:.|:..|.|.|||.|:|.||...|...::.:..:       .|:||...||.|.:.||.|.
Zfish   677 AFPLELQKKLLHFTTGSDRVPVGGMADLNFKISKIDVS-------TDWLPVSHTCFNQICLPPYK 734

  Fly  3118 SREVMRQKLKVAAN--EG 3133
            |::.:||||.:|.:  ||
Zfish   735 SKKELRQKLTIAISNAEG 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	87/340 (26%)
hectd2	XP_009304826.1	HECTc	397..754	CDD:238033	88/343 (26%)
hectd2	XP_009304826.1	HECTc	420..753	CDD:214523	88/343 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900