DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and yap1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001132952.1	Gene:	yap1 / 561411	ZFINID:	ZDB-GENE-030131-9710	Length:	442	Species:	Danio rerio

Alignment Length:	428	Identity:	90/428 - (21%)
Similarity:	146/428 - (34%)	Gaps:	94/428 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 PPQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQHH 669
            ||:|.||.:|..........:.|.|..|| ||..:....|.:..|.....||:|...:..|..:.
Zfish    58 PPEPKSHSRQASTDAGTAGTVTPHHVRAH-SSPASLQLGAVSPGALTSMGPANAPPQHLRQSSYE 121

  Fly   670 QHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTGAGPPPALFQ-QQAPPQLTRYTPAT 733
            ...........:.|:.|....|..:    |...    |:|...|..||.| .||.|
Zfish   122 IPDDMPLPPGWEMAKTPSGQRYFLN----HNDQ----TTTWQDPRKALLQMNQAAP--------- 169

  Fly   734 ATTAATFVPPQQQQVVYNPQ--------QQQHSSLRR----SSRGKTGSCVSSAAAAQQQQHHQQ 786
                |:.||.|||.:: ||.        :|..:|...    :.:.||.|.:....   ..:....
Zfish   170 ----ASPVPVQQQNIM-NPASGPLPDGWEQAITSEGEIYYINHKNKTTSWLDPRL---DPRFAMN 226

  Fly   787 QQHSSAAAAVQQ--QLLPPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQ 849
            ||..|.:|.|:|  ||   |.:.|...:.||..:       :|||...::::|.:..:..:|:.|
Zfish   227 QQRISQSAPVKQGSQL---PSSPQSGVMSGNNPI-------RLQQIHIEKERLRIKQELLRQRPQ 281

  Fly   850 QQQQQHQQQQHQQQQRATLVQPGFLFSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMA 914
            :...::|.....:|...|                          |.| |:......||...:..:
Zfish   282 ELALRNQLPTSMEQDGGT--------------------------QNP-VSSPGMGQDARNMTTNS 319

  Fly   915 QQP--PSGPPHAGGQQITPGANSANLSIVAAA---LSAARDVGGGSD-GGGSAG----------G 963
            ..|  .||..|:..:....|.:.::.|:....   |::..::..|.. |.||..          .
Zfish   320 SDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMETGDTLGPGSMATQPSRFPDYLD 384

  Fly   964 ATPATGASASSVGNTSAVGASSSSNSSAGQAASSNSNN 1001
            |.|.|.....::...|..........|..:|.||:..|
Zfish   385 AIPGTDVDLGTLEGESMAVEGEELMPSLQEALSSDILN 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	11/43 (26%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
yap1	NP_001132952.1	FAM181	<41..186	CDD:291891	39/150 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..89		11/31 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..116		4/18 (22%)
		WW	127..158	CDD:197736	6/38 (16%)
		WW	188..217	CDD:278809	5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..254		8/26 (31%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:P46937	247..442		37/210 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..374		19/114 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900