DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ctrip and HERC6

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_005263140.1 Gene:HERC6 / 55008 HGNCID:26072 Length:1034 Species:Homo sapiens


Alignment Length:1241 Identity:233/1241 - (18%)
Similarity:399/1241 - (32%) Gaps:431/1241 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1990 SGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQ 2054
            :|:....|.|....:::|..:      ...||...:   |..|..|.:.||.:...:...|.:..
Human   113 AGSEGQLGIGEFKEISFTPKK------IMTLNDIKI---IQVSCGHYHSLALSKDSQVFSWGKNS 168

  Fly  2055 ------AVDFVKRYTEQEAKRSK----AASESGATQS------GSS-GVGLSSTG---------- 2092
                  ..:|..:.:.|..:..:    |...:|...|      |:| |.|.:|.|          
Human   169 HGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVP 233

  Fly  2093 ---NTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESD--ISPFEVNHSGLIKAM 2152
               |.|||.....|           |...|..|.||    .|.:|..|  :..|..|.||     
Human   234 VQSNKPLSVGALKN-----------LGVVYISCGDA----HTAVLTQDGKVFTFGDNRSG----- 278

  Fly  2153 LNYMTSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMPTIE---PIAFGAFVAKLNGCVTQLE 2214
                                              .:|..||.|   |    ..|.:::|.|:|::
Human   279 ----------------------------------QLGYSPTPEKRGP----QLVERIDGLVSQID 305

  Fly  2215 ----------QFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDP 2269
                      ....:|..|..||...|..:                ||:..        |...|.
Human   306 CGSYHTLAYVHTTGQVVSFGHGPSDTSKPT----------------HPEAL--------TENFDI 346

  Fly  2270 LAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVY 2334
            ..::.|                      ||..|         ...:|....|..:.|     |.:
Human   347 SCLISA----------------------EDFVD---------VQVKHIFAGTYANFV-----TTH 375

  Fly  2335 QAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQ 2399
            |............||....|:::   |..|:   .:..|..|.|:.........||.:..::...
Human   376 QDTSSTRAPGKTLPEISRISQSM---AEKWI---AVKRRSTEHEMAKSEIRMIFSSPACLTASFL 434

  Fly  2400 KQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKP 2464
            |::.:..:.|..|:...:..:..       .||||                 |.|:.::.:.|:.
Human   435 KKRGTGETTSIDVDLEMARDTFK-------KLTKK-----------------EWISSMITTCLED 475

  Fly  2465 FLSSSLPADVVTVQDASLDALCML---RVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKAN 2526
            .|..:||..  :....:|....:|   .|:|. :::|.:|        ::|         .|||.
Human   476 DLLRALPCH--SPHQEALSVFLLLPECPVMHD-SKNWKNL--------VVP---------FAKAV 520

  Fly  2527 RQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESS 2591
            .::.          .|.|..:.....||                                 .|||
Human   521 CEMS----------KQSLQVLKKCWAFL---------------------------------QESS 542

  Fly  2592 ERVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYE------------------NEVGT 2638
              :.|.:...|.||. :::|.|.: ..||..:.||||.:..|                  ||   
Human   543 --LNPLIQMLKAAII-SQLLHQTK-TEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINE--- 600

  Fly  2639 GLGPTLEFYA-----------LVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDAL 2692
             |...|.||.           |:.||   |...:......:..||::.:.:::|:|   ||:..:
Human   601 -LSNLLNFYIDRGRQLFRDNHLIPAE---TPSPVIFSDFPFIFNSLSKIKLLQADS---HIKMQM 658

  Fly  2693 EATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPT----RSSSRSHVLRSGAGQQPVEHSSSS 2753
            ....          |.::...    |...::.:.||:    ....||.:::....|      .|.
Human   659 SEKK----------AYMLMHE----TILQKKDEFPPSPRFILRVRRSRLVKDALRQ------LSQ 703

  Fly  2754 AGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAV- 2817
            |.|.:....:|:  :|.:........:                             ::.:.|.: 
Human   704 AEATDFCKVLVV--EFINEICPESGGV-----------------------------SSEFFHCMF 737

  Fly  2818 -------HGLFPLP-LGKSSKLPQMTKAKAKFKFL-GKFMAKAVMDSRMLDLPFSLPFYRWLVSE 2873
                   :|:|..| :|.....|...|.:.|..|| |.....::.:..:.:|||.|..|:.|:.:
Human   738 EEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQ 802

  Fly  2874 EHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLG--- 2935
            :.|  |.||..::|.:..:|..:.|              ||.:                |:|   
Human   803 KPS--LEDLKELSPRLGKSLQEVLD--------------DAAD----------------DIGDAL 835

  Fly  2936 -LDFVLPGHAN-IELCRGGRDTPVTVHNLHQYIS-LVTYWFLIEGVQKQFEALREGFDSVFPIQR 2997
             :.|.:....| ::|...|...||...|...|:| .:.|.|.: .|:..:|..:.||..|...:.
Human   836 CIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNV-SVKAVYEEFQRGFYRVCEKEI 899

  Fly  2998 LRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILASYNRDEQRAF 3062
            ||.||||||.....|      ::.::.|..:::.:.:.|:.:....||..::.......||::.|
Human   900 LRHFYPEELMTAIIG------NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKF 958

  Fly  3063 LQFVTGSPRLPTGGFKALTPPLTIVR--KTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQK 3125
            |.|:||..||...|.:.:.   .:.|  :|..|..:|..     :||.|.|.||.||:.|.|.:.
Human   959 LFFLTGRDRLHARGIQKME---IVFRCPETFSERDHPTS-----ITCHNILSLPKYSTMERMEEA 1015

  Fly  3126 LKVAAN 3131
            |:||.|
Human  1016 LQVAIN 1021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922
FAM199X <1985..2074 CDD:292442 15/93 (16%)
HECTc <2818..3138 CDD:294058 84/324 (26%)
HERC6XP_005263140.1 RCC1_2 27..54 CDD:290274
RCC1_2 89..118 CDD:290274 1/4 (25%)
RCC1 105..155 CDD:278826 10/50 (20%)
RCC1 158..208 CDD:278826 6/49 (12%)
RCC1 215..263 CDD:278826 15/62 (24%)
RCC1_2 250..279 CDD:290274 11/71 (15%)
RCC1 266..313 CDD:278826 14/89 (16%)
HECTc 684..1026 CDD:238033 93/422 (22%)
HECTc 711..1026 CDD:214523 87/389 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.