DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and HERC5

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	1443	Identity:	241/1443 - (16%)
Similarity:	432/1443 - (29%)	Gaps:	521/1443 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1787 VHFQQP-AVPAPPPQQELLPSGVQQ--QGQQVPQVIYQPHHQQPAHLVLASTSSGAASSSSSSSS 1848
            :.|:.| .:.||||....   |..:  :|......:.:.|....:...|.|.:..|..:.|..:.
Human    75 IMFRFPLELQAPPPNSTW---GAWRPGRGSVAEAAVPRRHAAARSWFPLCSATPEAVGALSPGTR 136

  Fly  1849 SSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQ---EDAAVAPAGSGPGGAP---PSSSGSAM 1907
            .|..|.|     .:..|||..:|:|:...|...|.   :.||..||.| ||...   ||::|  :
Human   137 RSLLSPL-----GLGPRKAAMERRSRRKSRRNGRSTAGKAAATQPAKS-PGAQLWLFPSAAG--L 193

  Fly  1908 HELLSRATSLGSG---NGGRSTPNSGGGSGSSKSRFNAG------------------NSSNAGSS 1951
            |..|.|...:...   :.||......||:|....:..||                  :|.:.|:.
Human   194 HRALLRRVEVTRQLCCSPGRLAVLERGGAGVQVHQLLAGSGGARTPKCIKLGKNMKIHSVDQGAE 258

  Fly  1952 KSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGL-AYTVSQHG-AG 2014
            ....|:| :...:....:...|...:...|:...:....|:.:|.....|..| |:..:.|| .|
Human   259 HMLILSS-DGKPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLG 322

  Fly  2015 SG--------------AGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQ 2065
            .|              ..|:..|.::|      ..|:.:|.:.......|
Human   323 VGRKFPSTTTPQIVEHLAGVPLAQISA------GEAHSMALSMSGNIYSW--------------- 366

  Fly  2066 EAKRSKAASESGATQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCL---DALL 2127
                       |..:.|..|:|.:.:.:.|....|..|     ..:.|...|..|..|   |.||
Human   367 -----------GKNECGQLGLGHTESKDDPSLIEGLDN-----QKVEFVACGGSHSALLTQDGLL 415

  Fly  2128 ---------ELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEP 2183
                     :|.....::::.|.      |:..::.|..::..
Human   416 FTFGAGKHGQLGHNSTQNELRPC------LVAELVGYRVTQIA---------------------- 452

  Fly  2184 LLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALR---------FF 2239
                .|:..|:      |:|:.|.           ||..|.:|..|:......|         ..
Human   453 ----CGRWHTL------AYVSDLG-----------KVFSFGSGKDGQLGNGGTRDQLMPLPVKVS 496

  Fly  2240 NTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNV 2304
            ::.:||  |:.|.....|....||...|  |..::....|:
Human   497 SSEELK--LESHTSEKELIMIAGGNQSI--LLWIKKENSYV------------------------ 533

  Fly  2305 AAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQ-H 2368
                        .|:.||                   |.::|            |....|:.. .
Human   534 ------------NLKRTI-------------------PTLNE------------GTVKRWIADVE 555

  Fly  2369 TIHYRPVEEEVTSGAAAGAASSSSSCSSG--VQKQQSSSSSASSCVNATSSCSSSSGVASGGGSL 2431
            |..::..:.|:..      ..||.:|.:|  ::|::::...                      .:
Human   556 TKRWQSTKREIQE------IFSSPACLTGSFLRKRRTTEMM----------------------PV 592

  Fly  2432 TKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCML---RVIHA 2493
            ....:|:.:.|.....:.|   |..::.:.||..|...||..  :....:|:...:|   .::|
Human   593 YLDLNKARNIFKELTQKDW---ITNMITTCLKDNLLKRLPFH--SPPQEALEIFFLLPECPMMH- 651

  Fly  2494 LNRHWDHLYGCVVRQNIIP----------QSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIG 2548
            ::.:|:.|        ::|          ||..:..:..|.........||.|
Human   652 ISNNWESL--------VVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQM------------ 696

  Fly  2549 MACPFLFPFETR---HLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEI 2610
                    |:|.   .|.::..|.:.:..:|.||:             :..:|.|.|:
Human   697 --------FKTAVICQLDYWDESAEENGNVQALLE-------------MLKKLHRSKK------- 733

  Fly  2611 LKQAEHILQDFGHSKALLE---IQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSDSYKQNS 2672
                         .||.|.   |:.|.|....|.||.:.
Human   734 -------------HKAYLRSAAIEEERESEFALRPTFDL-------------------------- 759

  Fly  2673 VTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHV 2737
                 .|:.|..   |||.|...:..:|                              ...|..:
Human   760 -----TVRRNHL---IEDVLNQLSQFEN------------------------------EDLRKEL 786

  Fly  2738 LRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNS 2802
            ..|.:|    |......|..:.....:.|:.
Human   787 WVSFSG----EIGYDLGGVKKEFFYCLFAEM---------------------------------- 813

  Fly  2803 SIITTTTTTSYVHAVHGLFPLPLGKSSK-LPQMTK-AKAKFKFLGKFMAKAVMDSRMLDLPFSLP 2865
                       :...:|:|..|.|.|.. .|...| .|.::.|.|.....::.:..:.:|||.|.
Human   814 -----------IQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLA 867

  Fly  2866 FYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCP 2930
            .::.|:.:..|  |.||..::|::...|..|.|              |..:..|::..:
Human   868 LFKKLLDQMPS--LEDLKELSPDLGKNLQTLLD--------------DEGDNFEEVFYI------ 910

  Fly  2931 IADLGLDFVLPGHANI-------ELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREG 2988
                        |.|:       .|...|....|...|...|:|....:...:.|:..:|..|.|
Human   911 ------------HFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRG 963

  Fly  2989 FDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILAS 3053
            |..:.....:::|:||||:.|..|      ::.::.|..:::.|.:.|::.....|...::....
Human   964 FYKMCDEDIIKLFHPEELKDVIVG------NTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHK 1022

  Fly  3054 YNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSS 3118
            ...:|::.||.|:||:.||.......:.     :.....|:.|..|.: ..:||.:.|.||.||:
Human  1023 LTLEEKKKFLVFLTGTDRLQMKDLNNMK-----ITFCCPESWNERDPI-RALTCFSVLFLPKYST 1081

  Fly  3119 REVMRQKLKVAAN 3131
            .|.:.:.|:.|.|
Human  1082 METVEEALQEAIN 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	15/104 (14%)
		HECTc	<2818..3138	CDD:294058	71/323 (22%)
HERC5	XP_011530324.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900