DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Magi2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_006535806.1	Gene:	Magi2 / 50791	MGIID:	1354953	Length:	1414	Species:	Mus musculus

Alignment Length:	1175	Identity:	209/1175 - (17%)
Similarity:	322/1175 - (27%)	Gaps:	502/1175 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQSLSALT------------EGQ---------HDDGGSTATSA---------TLANKTSGTNTTS 41
            |||:..:|            :||         |||..|.|:|.         |:.....|...|.
Mouse   554 SQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTI 618

  Fly    42 ASNHSSQRRR------------------NNNTNSNRNKSH--------------------HKN-- 66
            |.:.:.||.:                  ..|..:.:|.||                    |:.
Mouse   619 ADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGF 683

  Fly    67 --------------EKRNAPAT--SGPAVSSSVDVVPATSTAS------ATSTRRSRSQGRHSSA 109
                          |.:.:|.|  |.|||..::...||...:|      |...|:......:..:
Mouse   684 FSPWKTPKPMMDRWENQGSPQTSLSAPAVPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKS 748

  Fly   110 AALSSKESQIPKRSVGAIRSPSSPAFNSIPVVSDQSLSPGSRKRQLNQHNNSNNKASSSHQSAPG 174
            .|:.....|:|.|:  :.|..||                |...::|:.|  .....|.......|
Mouse   749 RAIYESRQQVPPRT--SFRMDSS----------------GPDYKELDVH--LRRMESGFGFRILG 793

  Fly   175 GDQLVCAPLKKRRLQQSLGSGICEGAVEINLGAASFDHTPRQASGD--------CVAQRTRSKTI 231
            ||:    |          |..|..||| |.:|:|  |...|...||        .||.:|....|
Mouse   794 GDE----P----------GQPILIGAV-IAMGSA--DRDGRLHPGDELVYVDGIPVAGKTHRYVI 841

  Fly   232 SPEELPSTSSAAAARHHQIRPSASSTSFSSSHRNKRKASIGGSIAAVETTPHRGTAAARAGRSGN 296
            .            ..||..|....:.:.      :||...||     |..|..|
Mouse   842 D------------LMHHAARNGQVNLTV------RRKVLCGG-----EPCPENG----------- 872

  Fly   297 LLNYYRKTRKVSHTRSSQKSEKQSIPAEDTTANRNGSAGSGSSSKSGVIPKNRKSLRHSQQNLLD 361
                 |....||...||.:|:..      |.:|.|.:|.|.::|.    |:...|  ||.|
Mouse   873 -----RSPGSVSTHHSSPRSDYA------TYSNSNHAAPSSNASP----PEGFAS--HSLQ---- 916

  Fly   362 TEAAEVESAAAETGGEQQSEHGNLDVIDQLPTPEAGPNQSEASGIHNQSQLEADRQPVVQDEDDE 426
                                  ..||:                 ||
Mouse   917 ----------------------TSDVV-----------------IH------------------- 923

  Fly   427 EDDEEEEEEEEEEVGFYGIVNSAGSSYEEDTQIVAEEDEITTEEEVDDEDDDEIEEEDLSESEFA 491
                   .:|.|..||. |::|.
Mouse   924 -------RKENEGFGFV-IISSL------------------------------------------ 938

  Fly   492 QQLIGELGGERQQPQRATNNAKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAPGAG 556
                                      |.|...|..|:                 ||..|...
Mouse   939 --------------------------NRPESGATITV-----------------PHKIGRII--- 957

  Fly   557 GGGPRATRSSNSNSSNNVV---DYSI--MPHLTTVATTTPHALT------PQQHQQQRQPPQPPS 610
            .|.| |.|.:.....:.::   ..||  |||...|.......|:      ||  ::...|...||
Mouse   958 DGSP-ADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQ--EELNSPTSAPS 1019

  Fly   611 HQQQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQHHQHQHQH 675
            .::|....||..|       .|..|....|:.|...:..|...||..      .|.|.|::.::.
Mouse  1020 SEKQSPMAQQHSP-------LAQQSPLAQPSPATPNSPVAQPAPPQP------LQLQGHENSYRS 1071

  Fly   676 QQQHVQQAQAP--QPHY--YHSSVAVLHQPPPHHFTSTGAGPPPALFQQQAPPQLTRYTPATATT 736
            :.:..|..:..  ||.:  |........|||...::.    |||..::|.:|.  ||..|
Mouse  1072 EVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQ----PPPLDYRQHSPD--TRQYP----- 1125

  Fly   737 AATFVPPQ--------------------------------------------------QQQVVYN 751
            .:.:..||                                                  .|.:..|
Mouse  1126 LSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEIN 1190

  Fly   752 PQQQQHSSLRRS-----SRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQ---------QQLL- 801
            .:..:..:..|:     |.|:....:......|..::.:....|:||||..         :.:|
Mouse  1191 GESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPHAWSAAAAAAPGLPEVGVSLEDILS 1255

  Fly   802 ------PPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQH 860
                  |.|.:....|:|.:..                   ..:..:|..::.::.....|::|.
Mouse  1256 PFSPSHPAPPSDPSHQIGPDPT-------------------WDIQREHDVRKPKELSAGGQKKQR 1301

  Fly   861 QQQQRATLVQPGFLFSYRSNQPQQQQQPAQQ--IHQGPKVTHSSAASDALTYSLMAQQPPSGPPH 923
            ..:||.....|     .||.:|:.::.|..|  ...|...:.::...:||      :....|...
Mouse  1302 LGEQRERSASP-----QRSARPRLEEVPGGQGRPEAGRPASEAADGKEAL------RGRREGLGA 1355

  Fly   924 AGGQQITPGANSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVGASSSSN 988
            ||.::.     .|.:.:.:.|..|||..     |||.|..||.|.| .....|:....||.....
Mouse  1356 AGAREA-----EAKVGVRSGARPAARPT-----GGGPARKATMAPG-PWKVPGSDKLPGALQPGA 1409

  Fly   989 SSAGQ 993
            |:||:
Mouse  1410 SAAGR 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	12/44 (27%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Magi2	XP_006535806.1	PDZ_signaling	22..96	CDD:238492
		NK	118..290	CDD:388413
		WW	303..332	CDD:366073
		WW	349..378	CDD:366073
		PDZ	427..508	CDD:214570
		PDZ	601..682	CDD:214570	11/80 (14%)
		MAGI_u5	681..755	CDD:374709	13/73 (18%)
		PDZ	774..860	CDD:214570	26/122 (21%)
		PDZ_signaling	919..1006	CDD:238492	28/219 (13%)
		PDZ_signaling	1138..1218	CDD:238492	5/79 (6%)
		MAGI_u1	1245..1285	CDD:374706	5/58 (9%)
		PHA03307	<1255..>1407	CDD:223039	37/192 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900