DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and NEDD4

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001271267.1	Gene:	NEDD4 / 4734	HGNCID:	7727	Length:	1319	Species:	Homo sapiens

Alignment Length:	1792	Identity:	346/1792 - (19%)
Similarity:	551/1792 - (30%)	Gaps:	704/1792 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1529 NLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYS---SSAGPNVRYKCLRALLRMVYY 1590
            |:.|:|..|...|....:||             ||..:..|   ||...|.:..||:..|:...|
Human    45 NVVQMKLTPRQTALAPLIKE-------------NVQSQERSSVPSSENVNKKSSCLQISLQPTRY 96

  Fly  1591 ATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGVIYQFTQL 1655
            :                               |.||.:.:| ....|...|...::| ||.
Human    97 S-------------------------------GYLQSSNVL-ADSDDASFTCILKDG-IYS---- 124

  Fly  1656 TDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTTP-SSSKH 1719
                            ||......||              ||...:.|:|.:.|.|.:. |:|.:
Human   125 ----------------SAVVDNELNA--------------VNDGHLVSSPAICSGSLSNFSTSDN 159

  Fly  1720 QSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVTQQGDPR 1784
            .||              |:.|:..|    :.:|.|:|| :|::|..|.||
Human   160 GSY--------------SSNGSDFG----SCASITSGG-SYTNSVISDSS--------------- 190

  Fly  1785 QYVHFQQPAVPAPPPQQEL-----LPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASSSS 1844
            .|..         ||..:.     |||. ....:.||.               .:|:.....|.|
Human   191 SYTF---------PPSDDTFLGGNLPSD-STSNRSVPN---------------RNTTPCEIFSRS 230

  Fly  1845 SSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHE 1909
            :|:.......|:|.:..|   |.|..|.::.   ...|.....:.|  ..|....|:|. :::..
Human   231 TSTDPFVQDDLEHGLEIM---KLPVSRNTKI---PLKRYSSLVIFP--RSPSTTRPTSP-TSLCT 286

  Fly  1910 LLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNA----GSSKSSFLASLNPARWGRQTHQ 1970
            |||:                  ||..:..:|....|..|    |:|...||::
Human   287 LLSK------------------GSYQTSHQFIISPSEIAHNEDGTSAKGFLST------------ 321

  Fly  1971 NHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASISKSISH 2035
                                       :.:|..|:.|:...|.......|:.   ..|:.|.|..
Human   322 ---------------------------AVNGLRLSKTICTPGEVRDIRPLHR---KGSLQKKIVL 356

  Fly  2036 ANLLAAANRERARQWVREQAVDFVK----RYTEQEAKRSKAASESGATQSGSSGVGLSSTG---- 2092
            :|       ...||.|.|::.:...    .:|:::|......:.:|..:...|.:.|:|..
Human   357 SN-------NTPRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIK 414

  Fly  2093 ---NTPLSTAGSTNV---------LERLSSILFK----------LNGSYHD--CLDALLELKTIL 2133
               .|......|.||         |||..|.:.|          |.|:|.:  ||.:|
Human   415 LMHRTSACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSL------- 472

  Fly  2134 LESDISPFEVNHSGLIKAMLNYMTSETGLVE---RDARLRSFMHV---------FAG---LPLEP 2183
                  ....:..|..:.::.:.:...|.|:   ||:.......:         |.|   :||.|
Human   473 ------KHNCSKGGPSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYP 531

  Fly  2184 L-LQNVGQMPTIE-PIAFGAFV---------------------AKLNG----------------- 2208
            | .:|    |.:| |..|..||                     .|.:|
Human   532 LPTEN----PRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWV 592

  Fly  2209 --------CVTQLEQFPVKVHDFPAGPGGRSNQSAL--RFFNTHQLKCNLQRHP-QCNNLRQWKG 2262
                    |..|.:|.|     .|..||....|..|  .::..|:.:....:.| ..:||...:.
Human   593 VLDQPDAACHLQQQQEP-----SPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAEN 652

  Fly  2263 GTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSE-----EDMDDNVAAVVLSQA--SFRHKLQF 2320
            |.:::      || :|....|.......:|.|:.|     |.:.::.|.:..:||  |.......
Human   653 GNIQL------QA-QRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNL 710

  Fly  2321 TIGDHV---LPYNMTVYQAVKQFSPLVSEQPETDNESETLLGN--ASIWVQQHTIHYRPVEEEVT 2380
            .:..|:   |...:|:      |......||.:.:...:..|:  |..:.:|.|:   ||....:
Human   711 DVPTHLAEELNARLTI------FGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTL---PVLLPTS 766

  Fly  2381 SGAAAG----------------------------------AASSSSSCSSGVQKQQSSSSSASSC 2411
            ||...|                                  :..:||..|:|.|.|.|:|.|..
Human   767 SGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQ-- 829

  Fly  2412 VNATSSCSSSSGVASGGGSLTKKAHKSSSKFM--RKKTELWHEGIAPVVISALKPFLSSSLPADV 2474
             ..|.......|....|..: :.|......|:  ..||..|.:           |.|  .:||.:
Human   830 -QVTQPSEIEQGFLPKGWEV-RHAPNGRPFFIDHNTKTTTWED-----------PRL--KIPAHL 879

  Fly  2475 --VTVQDASLDALCMLRVIHALNRHWD---HLYGCV--VRQNIIPQSDFIHPKIMAKANRQLQDP 2532
              .|..|.|.|       :..|...|:   |..|.:  :..||              ...|.:||
Human   880 RGKTSLDTSND-------LGPLPPGWEERTHTDGRIFYINHNI--------------KRTQWEDP 923

  Fly  2533 L---VIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDL-NAAESSER 2593
            .   |.:|          |.|.|:...::.::..|           :|.|....|: |..|...|
Human   924 RLENVAIT----------GPAVPYSRDYKRKYEFF-----------RRKLKKQNDIPNKFEMKLR 967

  Fly  2594 VAPRLD---RRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTL-EFYALVSAEL 2654
            .|..|:   ||...:.|.:.|             ||.|.|:::.|.|...|... |::.|:|.|:
Human   968 RATVLEDSYRRIMGVKRADFL-------------KARLWIEFDGEKGLDYGGVAREWFFLISKEM 1019

  Fly  2655 QRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTT 2719
            .....||:                              |.:.||..|
Human  1020 FNPYYGLF------------------------------EYSATDNYT------------------ 1036

  Fly  2720 TAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPS 2784
                                       ::.:.:|...||:.|
Human  1037 ---------------------------LQINPNSGLCNEDHL----------------------- 1051

  Fly  2785 STTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMA 2849
                                       ||                           |||:|:...
Human  1052 ---------------------------SY---------------------------FKFIGRVAG 1062

  Fly  2850 KAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDA 2914
            .||...::||..|..|||:.::.:  .|.|.|:..|..|..|:|         |..:.:||
Human  1063 MAVYHGKLLDGFFIRPFYKMMLHK--PITLHDMESVDSEYYNSL---------RWILENDP---- 1112

  Fly  2915 MEKTEKIEQLDLDGCPIADLGLDFVL------PGHANIELCRGGRDTPVTVHNLHQYISLVTYWF 2973
                             .:|.|.|::      ..|.: ||..||.:..||..|..:||.||..|.
Human  1113 -----------------TELDLRFIIDEELFGQTHQH-ELKNGGSEIVVTNKNKKEYIYLVIQWR 1159

  Fly  2974 LIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFH 3038
            .:..:|||..|.:|||..:.|...:::|...|||.:.||.|....:. |     :|..:..:|:.
Human  1160 FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVND-W-----REHTKYKNGYS 1218

  Fly  3039 QDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL---TPPLTIVRKTLDENQNPNDY 3100
            .:.|.||:.::.:...:.:::...||||||:.|:|..||..|   ..|.:.   |:::...| :.
Human  1219 ANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSF---TVEQWGTP-EK 1279

  Fly  3101 LPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSF 3137
            ||...||.|.|.||.|.|.|.:..||::|. |.:..|
Human  1280 LPRAHTCFNRLDLPPYESFEELWDKLQMAI-ENTQGF 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	15/92 (16%)
		HECTc	<2818..3138	CDD:294058	89/329 (27%)
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..229		6/40 (15%)
		C2	<517..570	CDD:417471	13/56 (23%)
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		91/482 (19%)
		WW	611..643	CDD:197736	7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..780		7/27 (26%)
		WW	769..798	CDD:395320	1/28 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..834		10/40 (25%)
		WW	842..871	CDD:395320	6/40 (15%)
		WW	893..925	CDD:197736	9/45 (20%)
		HECTc	986..1315	CDD:214523	112/537 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900