DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Ube3a

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	202/944 - (21%)
Similarity:	341/944 - (36%)	Gaps:	253/944 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2292 SDDDSE---------EDMDDNVAAVVLSQ---ASFRHKLQFTIGDHVLPYNMTVYQAVKQF--SP 2342
            |..|||         ..:|.|....:..|   |....::...||        .|:.:|.:.  |.
  Fly   171 SSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIG--------VVFSSVDRLGKSF 227

  Fly  2343 LVSEQPETDNESETLLGNASIWVQQHTIH------------YRPVEEEVTSGAAAGAASSSSSCS 2395
            :.|.:|...:..:.||.|:...:.:..:.            .:.|:|:  |.:||.|.:::.|..
  Fly   228 IRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQ--SESAANATATAESVE 290

  Fly  2396 SGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVIS 2460
            |..:.::...       :..||.||.:.|...|              :|:...|    :....|.
  Fly   291 SEAEPEEEDD-------DVCSSQSSDTLVDLPG--------------LRRVQRL----LFGCQIR 330

  Fly  2461 ALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVV--------RQNIIPQSDFI 2517
            |:...|:||    |:.:.|         .||: :...|:.:..|:|        ..|.:...|::
  Fly   331 AITEKLTSS----VIQLSD---------WVIY-MRTDWERVIHCLVICFDLATNTNNSVVDMDYL 381

  Fly  2518 H---PKIMAKANRQ---LQDPLV-IMTGNLPQWLPQIGMAC------PFLFPFETRH-------- 2561
            .   ||:...|:..   .|..|. |...:....|..:..||      ..|...|:..
  Fly   382 DRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISV 446

  Fly  2562 -----LLFY----ATSFDRDRALQRLLDTTPDLNAAESS-------------------------- 2591
                 ::||    |:..:|......|.|.|....|:.|:
  Fly   447 TKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFE 511

  Fly  2592 -ERVAPRLDRRKRAISRTEILKQA--EHIL--QDFGHSKALLEIQYENEVGTGLGPTLEF--YAL 2649
             |.....:|.||..|...|...:|  |:|.  .|:...|.|   ..|:|:|:|......|  ||.
  Fly   512 KELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTL---AMESEIGSGHANYFSFMLYAF 573

  Fly  2650 VSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIED----ALEATT-TDQ-NTPAVAGAS 2708
            :.....:.|...::..........:.:..:..|...:..||    .|:.|. .|| ...|:.|..
  Fly   574 ILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLE 638

  Fly  2709 LVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTN 2773
            :|:.|..               ...:..::....|:|.::    ..|.::....:::.:.|
  Fly   639 MVAMSNP---------------KDLKKQLVVEFVGEQGID----EGGVSKEFFQLIVEEIF---- 680

  Fly  2774 SANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAK 2838
              |||          ....:|...|.|           .:.:|.    |...|
  Fly   681 --NPA----------FGMFIQQEETNN-----------MWFNAT----PFENG------------ 706

  Fly  2839 AKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQR 2903
            |:|..:|..:..|:.::..|.:.|.:..||.|:.  :....|||...:|.:..:|..:.|
  Fly   707 AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIG--YCGTFADLSDWSPALYKSLKSMLD----- 764

  Fly  2904 EYILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISL 2968
             |...|.. :..|:|.||...|:.|        |.|     ..||...|:|..|..||...:::|
  Fly   765 -YQGQDME-EVFEQTFKISYSDVFG--------DVV-----QHELVPNGQDVLVGQHNKELFVNL 814

  Fly  2969 VTYWFLIEGVQKQFEALREGFDSVFPIQRLR-MFYPEELECVFCGSGSEQQHSRWEIKMLQESCR 3032
            .:.:.|...:::||.|.|:||:.|.....|: :|.|||:|.:.|||      ..::...|:.|..
  Fly   815 YSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGS------REFDFVELENSTV 873

  Fly  3033 TDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNP 3097
            .:.|:.:.||.||..:.|:.:...:::...|:|.|||.|:|.||.|.|.  |.|.|...|
  Fly   874 YEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLR--LLITRHGPD----- 931

  Fly  3098 NDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAAN 3131
            :|.||:..||.|.|.||:|||||.:.::|..|.|
  Fly   932 SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAIN 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	92/315 (29%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	111/443 (25%)
		HECTc	647..970	CDD:214523	103/401 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900