DRSC/TRiP Functional Genomics Resources

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Protein Alignment ctrip and Hectd1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_006240148.1 Gene:Hectd1 / 362736 RGDID:1561653 Length:2610 Species:Rattus norvegicus


Alignment Length:2827 Identity:554/2827 - (19%)
Similarity:909/2827 - (32%) Gaps:1004/2827 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1089 LQGLQSHDESQQLQAAIEMCQMLVMGN--EDTLAGFPIKQVVPALIQLLRMEHNFD-IMNNACRA 1150
            ||..|..:...||.|..::|.:|:|.:  :......|.:..:|||.::...|...| ::....||
  Rat    13 LQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDESAPDNVLEVTARA 77

  Fly  1151 LAYMLEALPRSSGTVV---EAVPVFLEKLQVIQ-----CMDVAEQSLSALEILSRRHNKAILQAN 1207
            :.|.|:.....:..:|   .|:.....:|.|::     ..|:|||.:..||::..|.:.|:.:|.
  Rat    78 ITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELICTRESGAVFEAG 142

  Fly  1208 GISACLTYL-DFFSIVAQ---RAALAIAANCCLNMHPEE--FHFVAESLPLLARLLSQQDKKCIE 1266
            |::..||:: |...:|.:   .:|:|:.:..|..|.|::  .....||   |:.||..:|.:..:
  Rat   143 GLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVES---LSSLLKHEDHQVSD 204

  Fly  1267 SVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVT------------PAILNTGTFTA--- 1316
            .....|..|.:.|...|.....:|...|.:.....:...            |....||..:|   
  Rat   205 GALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGGTVSGPSSACKPGRSTTGAPSAAAD 269

  Fly  1317 ---------VVRMLSLMCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSEL 1372
                     :|.:||.:|...|.:...|||:::..::...|.|:......:...|:|        
  Rat   270 SKLSNQVSTIVSLLSTLCRGSPLVTHDLLRSELPDSIESALQGDERCVLDTMRLVDL-------- 326

  Fly  1373 YELTCLIGELMPRLP---------LDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDS 1428
              |..|:.|....||         :.|:..:||        :.::.|.|..|...|....:.||:
  Rat   327 --LLVLLFEGRKALPKSSAGSTGRIPGLRRLDS--------SGERSHRQLIDCIRSKDTDALIDA 381

  Fly  1429 RLIEAANQSSEDEIS------LSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVA----PM 1483
            ....|...:..|::.      .|.||....|:|...:..:.:.|     ||..:.:|.|    |.
  Rat   382 IDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRG-----QRSSSLHYAACFGRPQ 441

  Fly  1484 --------SAGQDLT----TTSAGSAAAGGASTSAAAAAASSNNNNNNNNNPPGN---SVNLNQV 1533
                    .|..||.    .|....|...|.|...|...:            ||:   .||....
  Rat   442 VAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQS------------PGDWMCPVNKGDD 494

  Fly  1534 KRRPSLDARIACLKEERG---LAADFIKHIFNVLYEVYSSSAGPNVRYKCLRALLRMVYYATPEL 1595
            |::...:.......|.:|   :|..::|.:..|..:.:..:..|::|...|..:.:|:::.:..|
  Rat   495 KKKKDTNKDEEECNEPKGDPEMAPVYLKRLLPVFAQTFQHTMLPSIRKASLALIRKMIHFCSEAL 559

  Fly  1596 LRQV--------LKYQLV--SSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGVIY 1650
            |::|        |...||  ::.:......:|..::  |||:...|:.:..|:|.....|.|||.
  Rat   560 LKEVCDSDAGHNLPTALVEITATVLDQEDDDDGHLL--ALQIIRDLVDKGGDIFLDQLARLGVIS 622

  Fly  1651 QFTQLTDPNNPICANPSPKP------------------------------------LSATATPTA 1679
            :.:.|..|::........||                                    ..|.|...:
  Rat   623 KVSALAGPSSDDENEEESKPEKEDEPQEDAKELQQGKPYHWRDWSVIRGRDCLYIWSDAAALELS 687

  Fly  1680 NA-----------------------GGSQSAPASANSL--------QVNPFFMD----SAPG--- 1706
            |.                       |||.|:.:.:..|        ||.|....    ||||   
  Rat   688 NGSNGWFRFILDGKLATMYSSGSPEGGSDSSESRSEFLEKLQRARGQVKPSTSSQPILSAPGPTK 752

  Fly  1707 ----------LSSASTTPSSSKHQSYSV-------------KSFSHAMNALTASAKGTPSG---- 1744
                      |........:|..|..::             :...|:..|.|:......:|    
  Rat   753 LTVGNWSLTCLKEGEIAIHNSDGQQATILKEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWTGK 817

  Fly  1745 -------ALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVTQQGDPRQY-----VHFQQPAVPAP 1797
                   .|:.|.........:.......:....|....||.:....|.     :|..:..:...
  Rat   818 RGRKLKSKLEKTKQKVRTMARDLYDDHFKAVESMPRGVVVTLRNIATQLESSWELHTNRQCIEGE 882

  Fly  1798 PPQQELLPSGVQ-------QQGQQVPQVIYQPHHQQPAHLVLASTSS-----------------G 1838
            ...::|:.:.::       .:....|..:......|....||.|:..                 .
  Rat   883 NTWRDLMKTALENLIVLLKDESTISPYEMCSSGLVQALLTVLNSSIDLDMKQDCSQLVERINVFK 947

  Fly  1839 AASSSSSSSSSSSASALQHKMTDMLK--RKAPPKRKSQSGG---------RAKSRQEDAAVAPAG 1892
            .|.|.|....|..|.||..|:..:|:  .:.|.......|.         |.:.|.|.|      
  Rat   948 TAFSESEDDESRPAVALIRKLIAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERA------ 1006

  Fly  1893 SGPGGA------------PPSSSGSAMHELLSRATS----------------LGSG--------- 1920
              ||..            .|.::..::.:.|.:..:                |..|         
  Rat  1007 --PGETALIDRTGRMLKMEPLATVESLEQYLLKMVAKQWYDFDRSSFVFVRKLREGQNFIFRHQH 1069

  Fly  1921 ----NG------------------------------GRSTPNSGGGSGSSKSRFNAGNSSNAGSS 1951
                ||                              ||:.|.  |......||.|:..:.::...
  Rat  1070 DFDENGIIYWIGTNAKTAYEWVNPAAYGLVVVTSSEGRNLPY--GRLEDILSRDNSALNCHSNDD 1132

  Fly  1952 KSSFLA------------SLNPAR-WGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAG 2003
            |:::.|            :|..|| :||...:|....          :|||..|..|        
  Rat  1133 KNAWFAIDLGVWVIPSAYTLRHARGYGRSALRNWVFQ----------VSKDGQNWTS-------- 1179

  Fly  2004 LAYT----VSQHGAGSGAG---------------------GLNAAAVAASISKS----------- 2032
             .||    .|.:..||.|.                     |.||:.....:|.|           
  Rat  1180 -LYTHVDDCSLNEPGSTATWPLDPAKDEKQGWRHVRLKQMGKNASGQTHYLSLSGFELYGTVNGV 1243

  Fly  2033 ----ISHANLLAAANRERARQWVREQAVDFVK-----------RYTEQE---------------- 2066
                :..|...|.||..|.|:.||.|.:.::.           ::.:|:                
  Rat  1244 CEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVTGELHNG 1308

  Fly  2067 ------------------------------------AKRSKAASESGATQSGSS----------- 2084
                                                :.:..:::.||.|||.||           
  Rat  1309 WIDVTWDAGGSNSYRMGAEGKFDLKLAPGYDPDTVASPKPVSSTVSGTTQSWSSLVKNNCPDKTS 1373

  Fly  2085 -GVGLSS---TGNTPLSTAGSTNV------LERLSSILFK---LNGSYHDCLDALLELKTILLES 2136
             ..|.||   :.::..|.|.|:::      .||.|.|:.:   ::|:  |..:.::.|.:   ..
  Rat  1374 AAAGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGA--DVHEPIVVLSS---AE 1433

  Fly  2137 DISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLE-------------PLLQNV 2188
            ::...||..|.  .|..:.:|:|||....:.:|.....|.|  |.|             |.:.:|
  Rat  1434 NVPQTEVGSSS--SASTSTLTAETGSENAERKLGPDSSVRA--PGESSAISMGIVSVSSPDVSSV 1494

  Fly  2189 GQMPTIE-------------------------PIAFGAFVAKLNGCVT-QLEQFPVKVHDFPAGP 2227
            .::...|                         |::..|.|..|:...| .||.|..:|.:. |..
  Rat  1495 SELTNKEAASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANI-ART 1558

  Fly  2228 GGRSNQSALRFF---NTHQLKCNL-----------QRHPQCNNLRQWKGGTVKIDPLAMVQAIER 2278
            ...:|.:..|..   ||:.|..|:           |..|...........|:....:.....:..
  Rat  1559 NATNNMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVAT 1623

  Fly  2279 YLVVRGYG--------------------------------------GIRADSDDD---------S 2296
            ...|...|                                      .:.|:.|||         .
  Rat  1624 ATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEPDEED 1688

  Fly  2297 EEDMDDN------VAAVVLSQASFRHKL--QFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNE 2353
            :|:.|||      ...::|.:.|.:.:.  :..:..|.:...:....:.....| :.||.|  .|
  Rat  1689 DENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPSGAGSRP-IGEQEE--EE 1750

  Fly  2354 SETLLGNASIW-------------------------VQQ---------HTIHYRPVEE-EVTSG- 2382
            .||..|....|                         |||         .|.|...:|| |.|.. 
  Rat  1751 YETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSELLEEVECTPSP 1815

  Fly  2383 ------AAAGAASSSS----------------------SCSSGVQKQ--------------QSSS 2405
                  ...|..::..                      ||:..|:..              :...
  Rat  1816 RLALTLKVTGLGTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYTIMYREMK 1880

  Fly  2406 SSASSCVNATSSCSSSSGVASGGGS-----------LTKKAHKS---------SSKFMRKKTELW 2450
            .|.....|....|.|...|....|:           |.|.|..:         ::|.:||...  
  Rat  1881 DSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTNKSIRKNRN-- 1943

  Fly  2451 HEGIAPVVISALKPF------------LSSSL-PADVVTVQDAS--------------LDALCML 2488
                ...:|:|.|.|            .|||| .:|::.:....              .|.|.:|
  Rat  1944 ----CSQLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKAGNGQNPCGVEDVLQLL 2004

  Fly  2489 RVIHALNRHWDHLYGCVVRQN-------IIPQSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQ 2546
            |:::.:.   ...|..:.:::       ..|..:|...||..|..:|:::||.:.:|.||.|..|
  Rat  2005 RILYIVA---SDPYSRISQEDGDEQPQFTFPPDEFTSKKITTKILQQIEEPLALASGALPDWCEQ 2066

  Fly  2547 IGMACPFLFPFETRHLLFYATSFDRDRALQRLLD----------TTPDLNAAESSERVAPRLDRR 2601
            :...||||.|||||.|.|..|:|...||:..|.:          ||..:...:..|....||...
  Rat  2067 LTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRVGRLKHE 2131

  Fly  2602 KRAISRTE-ILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGS 2665
            :..:.|.| :::.||:::|.....|::||:::..|.||||||||||||||:||.||||||.|...
  Rat  2132 RVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQRTDLGTWLCD 2196

  Fly  2666 DSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTR 2730
            |::..:....||:                                                    
  Rat  2197 DNFPDDESRHVDL---------------------------------------------------- 2209

  Fly  2731 SSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQH 2795
                      |.|.:|..:                                              
  Rat  2210 ----------GGGLKPPGY---------------------------------------------- 2218

  Fly  2796 NTTTNNSSIITTTTTTSYVHAVHGLFPLPLGK-SSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLD 2859
                             ||....|||..|..: |.:|.::||.   |.|||.|:||.:.|:|::|
  Rat  2219 -----------------YVQRSCGLFTAPFPQDSDELERITKL---FHFLGIFLAKCIQDNRLVD 2263

  Fly  2860 LPFSLPFYRWL--------------------------------VSEEH---SIG----------- 2878
            ||.|.||::.:                                ..|.|   |:|           
  Rat  2264 LPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFI 2328

  Fly  2879 -----------------LADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDL 2926
                             ..|...|.|.....|..::||..:|..||.:.::...||..|:::|.|
  Rat  2329 LDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQELVL 2393

  Fly  2927 -----DGCP--IADLGLDFV------LPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGV 2978
                 .|.|  |.||||:|.      :.|...::|...|.|..:|:.|..:|:.|:..:.:..|:
  Rat  2394 KNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGI 2458

  Fly  2979 QKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQA 3043
            |||.||.|:||:.|||:::|..|..||::.:.||:    |...|..:.:........|:.:||..
  Rat  2459 QKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN----QSPSWAAEDIINYTEPKLGYTRDSPG 2519

  Fly  3044 IQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCV 3108
            ......:|...:.||::|||||.||...||.||...|.|.||:|||.   :.....| |||.|||
  Rat  2520 FLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKV---DATDASY-PSVNTCV 2580

  Fly  3109 NYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            :|||||:|||.|:||::|..|..|  ..|||:
  Rat  2581 HYLKLPEYSSEEIMRERLLAATME--KGFHLN 2610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922 17/77 (22%)
FAM199X <1985..2074 CDD:292442 26/191 (14%)
HECTc <2818..3138 CDD:294058 122/396 (31%)
Hectd1XP_006240148.1 Ank_2 366..457 CDD:289560 20/95 (21%)
ANK repeat 366..393 CDD:293786 5/26 (19%)
ANK 369..479 CDD:238125 24/114 (21%)
ANK repeat 396..426 CDD:293786 6/34 (18%)
ANK repeat 428..457 CDD:293786 6/28 (21%)
F5_F8_type_C 1107..1240 CDD:304887 30/153 (20%)
MIB_HERC2 1277..1335 CDD:284184 1/57 (2%)
HECTc 2131..2608 CDD:238033 162/614 (26%)
HECTc 2155..2607 CDD:214523 157/589 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10145at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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