DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Herc3

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001102101.1	Gene:	Herc3 / 362377	RGDID:	1307803	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	1313	Identity:	251/1313 - (19%)
Similarity:	392/1313 - (29%)	Gaps:	570/1313 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly  1964 WGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNS------------TGSGSGAGLAYTVSQHGAGSG 2016
            ||:.:|            ...||.|:..:..|            ....:|...::.:|..||..|
  Rat   161 WGKNSH------------GQLGLGKEFPSQTSPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFG 213

  Fly  2017 AGGLNAAAVAASISK---SISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGA 2078
            .|..||..:..|..|   |..|..||            |.|.|.::....|..|.         .
  Rat   214 WGMNNAGQLGLSDEKDRESPCHVKLL------------RTQKVVYISCGEEHTAV---------L 257

  Fly  2079 TQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEV 2143
            |:||    |:.:.|      |||...|.             ||.::           .:::|
  Rat   258 TKSG----GVFTFG------AGSCGQLG-------------HDSVN-----------DEVNP--- 285

  Fly  2144 NHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMPTIEPIAFGAFVAKLNG 2208
                  :.:|..|.||...:....:     |..|.:|...|:           .|||.      |
  Rat   286 ------RRVLELMGSEVTQIACGRQ-----HTLALVPSSGLI-----------YAFGC------G 322

  Fly  2209 CVTQLE---------QFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGT 2264
            ...||.         ..|||.|  .|...|:.:..|.||
  Rat   323 AKGQLGTGHTCNVKCPSPVKGH--WAAHSGQLSARADRF-------------------------- 359

  Fly  2265 VKIDPLAMVQAIERYLVVRGY--GG----IRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIG 2323
                         :|.||:..  ||    :...:.::|...:|            ||
  Rat   360 -------------KYRVVKQIFSGGDQTFVLCSTYENSSPAVD------------FR-------- 391

  Fly  2324 DHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAA 2388
                    ||.||  .::.|:::        ||:    ::|.|:.|.|
  Rat   392 --------TVNQA--HYTNLIND--------ETI----AVWRQKLTEH----------------- 417

  Fly  2389 SSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKK--AHKSSS----------- 2440
             ::::..:||.:..||    ::|.|              |..|.||  .|..:|
  Rat   418 -NNANTVNGVVQILSS----AACWN--------------GSFLEKKIDEHFKTSPKIPGIDLNST 463

  Fly  2441 -----KFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVT------------VQDASLD----- 2483
                 |.|..:..:..|.|.....|.|.|.|||| |.||..            :||:...
  Rat   464 RVLFEKLMHSQHSMILEQILNSFESCLIPQLSSS-PPDVEAMRIYLILPEFPLLQDSKYYITLTI 527

  Fly  2484 --ALCMLRV----IHALNRHWDH-----------LYGCVVRQNIIPQSDFIHPKI---------- 2521
              |:.:||:    ...|:..|..           ||...|...:..:..|:.|.:
  Rat   528 PLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKSAVLYLLRGRKTFLIPVLFNNYMTATLK 592

  Fly  2522 ----MAKANRQLQ------------DPLVIMTGNLPQW-LPQIGM-ACPFLFPFETRHLLFYATS 2568
                :.|.|.:::            ..||.:..:...| |.|.|| |.|.:.. :...|..|...
  Rat   593 LLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQEDYLMWFLHQSGMKARPSIMQ-DAVTLCSYPFI 656

  Fly  2569 FDRDRALQRLLDTTPDL------NAAESSE-----RVAPRLDRRK---RAISRTEILKQAEHILQ 2619
            ||. :|..::|.|..:|      |.|....     .:.|.|.|..   ..:.|..::..|   |:
  Rat   657 FDA-QAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDA---LR 717

  Fly  2620 DFG-HS----KALLEIQYENEVGTGL-GPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDV 2678
            :.. ||    |..|::.::.|.|... |.|.||:.|:..||.....|::    :|.|:|
  Rat   718 ELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMF----TYYQDS------ 772

  Fly  2679 VKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAG 2743

  Rat   773 ----------------------------------------------------------------- 772

  Fly  2744 QQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTT 2808
                              |::   .|||                  |..|:||.
  Rat   773 ------------------NLL---WFSD------------------TCFVEHNW----------- 787

  Fly  2809 TTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSE 2873
                                            |..:|.....|:.:|.::||.|.|..|:.|::.
  Rat   788 --------------------------------FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNV 820

  Fly  2874 EHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNID-----------AMEKTEKIEQLDLD 2927
            :.|  |.||..::|....:|..|.|.          |..|           ..|....|||..|
  Rat   821 KPS--LEDLKELSPTEGRSLQELLDY----------PGEDIEETFCLNFTVCRESYGVIEQKKL- 872

  Fly  2928 GCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSV 2992
                        :||...:.:|:..|...|..:        |.|.|.| .|.:.:.|...||..|
  Rat   873 ------------IPGGDRVAVCKDNRQEFVDAY--------VNYIFQI-SVHEWYTAFSSGFLKV 916

  Fly  2993 FPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILASYNRD 3057
            ...:.|.:|.|.||..:..|:    .:..||  .|:|:......:......::..:|....:..:
  Rat   917 CGGKVLELFQPAELRAMMVGN----SNYNWE--ELEETAVYKGDYSSTHPTVKLFWETFHEFPLE 975

  Fly  3058 EQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVM 3122
            :::.||.|:|||.|:|..|..:|.   .:::.|    ....||||...||.|.|.||.|||:|:|
  Rat   976 KKKRFLLFLTGSDRIPIYGMASLQ---IVIQST----ATGEDYLPVAHTCYNLLDLPKYSSKEIM 1033

  Fly  3123 RQKLKVAAN--EG 3133
            :.:|..|.:  ||
  Rat  1034 KARLTQALDNYEG 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	23/103 (22%)
		HECTc	<2818..3138	CDD:294058	80/329 (24%)
Herc3	NP_001102101.1	ATS1	2..331	CDD:227511	52/267 (19%)
		RCC1	313..377	CDD:395335	21/121 (17%)
		HECTc	702..1048	CDD:238033	108/552 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900