DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Su(dx)

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	1011	Identity:	194/1011 - (19%)
Similarity:	341/1011 - (33%)	Gaps:	332/1011 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  2381 SGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSG-----VASGGGSLTKKAHKSSS 2440
            :|..|||||........|....|:|.:.:|...|.:|.|::.|     |.....||........:
  Fly     5 NGLPAGAASGGMEAGQTVNGAGSASPTPTSSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPN 69

  Fly  2441 KFM--------RKKTEL--------WHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLR 2489
            .::        ::||:|        |:|....::..      :|:|...|:.......||:...|
  Fly    70 PYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITP------NSTLHFKVLDHSSFRKDAMLGER 128

  Fly  2490 VI---HALNRHWD---HLYGCVVRQNIIPQSDFIHPK---IMAKAN--------RQLQDPLVIMT 2537
            :|   |.| :|::   ......:...:..:||....|   ::|..|        .|:|.......
  Fly   129 IINLAHIL-QHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAILNGLKLDMSKLQIQPVAGQQN 192

  Fly  2538 GNLPQWL--PQI------GMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAES---- 2590
            ||.|...  |.:      |.:|           :.|...    ||..||..::.:.|..|:
  Fly   193 GNPPVQAVNPSVVSDAAAGRSC-----------MIYGGV----RARMRLRSSSGNSNGGETRSPL 242

  Fly  2591 ---------SERVAPRLDRRKR-----------------AISRTEILKQ-------AEHILQDFG 2622
                     |.:..|..:::::                 |:.:|....|       |..:.|.:|
  Fly   243 PNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYG 307

  Fly  2623 HSKALLEIQYENEV------GTGLGPTLEFYALVSAELQRTDLGL--WNGSDSYKQNSVTIVDVV 2679
               ||.|......|      |..:||.    .:....:::..:||  ...:|...|......:.:
  Fly   308 ---ALPENTQPAAVYLPAGGGAAVGPP----GVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPL 365

  Fly  2680 KANSAV--------LHIEDALEATTTDQNTPAVAGASL----------VSSSTTTTT---TTAQQ 2723
            .|...:        .:::....:|..::.||...|..:          |..:|..||   ..:::
  Fly   366 PAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSER 430

  Fly  2724 HQHPPTRSSSRSHVLRSG--------AGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAI 2780
            ..|.......|:||:..|        ..|||...::.....:|:||..:.........|.|....
  Fly   431 LMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYF 495

  Fly  2781 DNPSSTTT--------------------------------ATTVVQHNT--TT------------ 2799
            .|..:.||                                ....|.|||  ||
  Fly   496 VNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGA 560

  Fly  2800 -------------------------NNSSI-----ITTTTTTSYVHAVHGLFPLP---------- 2824
                                     .::::     ||.|..|.:..:.|.:..||
  Fly   561 KGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYI 625

  Fly  2825 -----------------------------------LGKSSKLPQMTKAK-------AKFKFLGKF 2847
                                               ..|::...|:..|.       ..|||:|:|
  Fly   626 IFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRF 690

  Fly  2848 MAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNI 2912
            :|.|:...|.:...|::|||:.:::::  :.:.|:..:.||..|:|:.::           |.||
  Fly   691 IAMALYHGRFIYSGFTMPFYKRMLNKK--LTIKDIETIDPEFYNSLIWVK-----------DNNI 742

  Fly  2913 DAMEKTEKIEQLDLDGCPIADLGL------DFVLPGH-ANIELCRGGRDTPVTVHNLHQYISLVT 2970
            |                   :.||      ||.:.|. .:.||...|....||..|..:||:|:|
  Fly   743 D-------------------ECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMT 788

  Fly  2971 YWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH 3035
            .|.:..|:::|.:...|||:.|.|::.|:.|...|||.:.||. .:.....|:...:...
  Fly   789 EWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGM-QDVDVEDWQRNTIYRH----- 847

  Fly  3036 GFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALT----PPLTIVRKTLDENQN 3096
             ::::|:.:.:.::.:...:.:::...||||||:.|:|.|||..|.    |....:.|...|.
  Fly   848 -YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-- 909

  Fly  3097 PNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANE 3132
               :||...||.|.|.||.|.|.:.:.:||..|..|
  Fly   910 ---WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	88/378 (23%)
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	22/131 (17%)
		WW	364..396	CDD:197736	2/31 (6%)
		WW	397..426	CDD:278809	5/28 (18%)
		WW	478..509	CDD:197736	5/30 (17%)
		WW	522..554	CDD:197736	6/31 (19%)
		HECTc	594..946	CDD:238033	92/393 (23%)
		HECTc	620..946	CDD:214523	85/367 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900