DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Hecw2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001001883.1	Gene:	Hecw2 / 329152	MGIID:	2685817	Length:	1578	Species:	Mus musculus

Alignment Length:	1904	Identity:	347/1904 - (18%)
Similarity:	532/1904 - (27%)	Gaps:	789/1904 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1385 RLPLDGIF--------------------AVDSLLDRPTLN-----TQDQVHWQWRDDRGSWHNYS 1424
            |||.|.:.                    ||.::|...|:|     ..|:     .|..||.|: |
Mouse   305 RLPADHVSGYLQFKVEVTSSAHEDASPEAVGTILGVHTVNGDLGSPSDE-----EDMPGSHHD-S 363

  Fly  1425 TIDSRLIEAAN-QSSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQD 1488
            ||      .|| ..|||.::..|...:    |.....:..||                     :|
Mouse   364 TI------CANGPVSEDSVADGTPKHS----FRTSSTLEIDT---------------------ED 397

  Fly  1489 LTTTSAGSAAAGGASTSAAAAAASSNNNNNNNNNPP-GNSVNLNQV--------KRRPSLDARIA 1544
            |.:||                         :.|:|| |...:||..        ..||.     |
Mouse   398 LISTS-------------------------SRNSPPRGRQDSLNDYLDAIEHNGPARPG-----A 432

  Fly  1545 CLKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKC-----LRALLRMVYYATPELLRQVLKYQL 1604
            ....||                  |..|.|.:|...     |.|:|.:.........:|.|.|..
Mouse   433 ASSSER------------------SMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPS 479

  Fly  1605 VSSHIAGM-LGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGVIYQFTQLTDPNNPICANPSP 1668
            ......|: :.|...||..|:|                           |..|.|.:.
Mouse   480 SLEEEGGLIMCSRASRIDDGSL---------------------------TSQTKPEDD------- 510

  Fly  1669 KPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNA 1733
                   .|..|...|....||......|  ..:.|.|...:||.|..::.......|.......
Mouse   511 -------NPVENEDASIHETASLEERLEN--LPEVADGSLPSSTAPDENEANLEPQPSADQGSTE 566

  Fly  1734 LTASAK-GTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAP 1797
            |.:|.: ..|:...||.:|.|:.|....:|...|...|:          :|.|.....:|:.||
Mouse   567 LCSSQEVDQPTSGADAGASDTSGGSRRAASETESLDQGS----------EPSQVSSETEPSDPA- 620

  Fly  1798 PPQQELLPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDM 1862
             ..:.:..:..:.:|:..|:                     .|.||.:.|.::..|:::.:.:.:
Mouse   621 -RTESVSEASTRPEGESDPE---------------------GADSSCNESVTTQLSSVETRCSSL 663

  Fly  1863 LKRKAP--PKRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRS 1925
            ...:.|  |...||       .:||.|.|        |.|:|||.|              .|.:.
Mouse   664 ESARFPETPAFSSQ-------EEEDGACA--------AEPTSSGPA--------------EGSQE 699

  Fly  1926 ---TPNS-----------GGGSGSSKSRFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHH 1976
               ||:|           .|.:..:.:....|........:.|...:...|.....|
Mouse   700 SVCTPSSLPAVQVPSREEEGSAAEAAALSEQGELGEVWQRRGSLEGAAAAAPAAAAT-------- 756

  Fly  1977 QQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGA--GSGAGGLNAAAVAASISKSI------ 2033
             .||.|..|   |:|::.  |:..||    |..:.||  ||...|........|:.:.:
Mouse   757 -DSQPQEDG---DAGDAQ--GACEGA----TAQEEGATGGSQTNGHQPLRSLPSVRQDVSRYQRV 811

  Fly  2034 -------------SHANLLAAANRERARQWVR----------------EQAVDFVKRYTEQEAKR 2069
                         ||..:....:..|...|.|                :|.....:||  |..:|
Mouse   812 DEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRY--QSIRR 874

  Fly  2070 SKAASESGATQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILL 2134
            :..........|...|.|..:..:...:.....|||...:|                ....|:||
Mouse   875 TMTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHSTS----------------RSRLTLLL 923

  Fly  2135 ESD-----ISP--FEVNHSG-----------LIKAMLNYMTSETGLVER---DARLRSFMHVFAG 2178
            :|.     |||  |.|.||.           .:|.|:..:..:|...||   :..|..|:::||.
Mouse   924 QSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN 988

  Fly  2179 LPLEPLLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQ 2243
            ..||                                        .|.|...:.:.....||..|.
Mouse   989 KQLE----------------------------------------LPRGWEMKHDHQGKAFFVDHN 1013

  Fly  2244 LKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQA-------IERYLVVRGYGGIRADSDDDSEEDMD 2301
            .:.                 |..|||...:|:       :.|..:.|.    |:.|..:..||.
Mouse  1014 SRT-----------------TTFIDPRLPLQSSRPTSALVHRQHLTRQ----RSHSAGEVGEDS- 1056

  Fly  2302 DNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVK--QFSPLVSEQPETDNESETLLGNASIW 2364
                         ||     .|..|||...:.:..|.  |:..:|   |...|:      ....:
Mouse  1057 -------------RH-----AGPPVLPRPSSTFNTVSRPQYQDMV---PVAYND------KIVAF 1094

  Fly  2365 VQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGG 2429
            ::|..|      .|:                  :|::|...:
Mouse  1095 LRQPNI------LEI------------------LQERQPDLA----------------------- 1112

  Fly  2430 SLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHAL 2494
                :.|....|....:||                    ..|..|....||.|..|..|.....:
Mouse  1113 ----RNHSLREKIQFIRTE--------------------GTPGLVRLSSDADLVMLLSLFEEEIM 1153

  Fly  2495 NRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIGMA-----CPFL 2554
                          :.:|....:||.       ..|.|......: ||..|....|     .|:.
Mouse  1154 --------------SYVPPHALLHPS-------YCQSPRGSPVSS-PQNSPGTQRANARAPAPYK 1196

  Fly  2555 FPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQAEHILQ 2619
            ..||.:...||           |.|:|        ......|         .:.:::.:.:|:|:
Mouse  1197 RDFEAKLRNFY-----------RKLET--------KGYGQGP---------GKLKLIIRRDHLLE 1233

  Fly  2620 D-----FGHSKALLE-----IQYENEVGTGL-GPTLEFYALVSAELQRTDLGLWNGSDSYKQNSV 2673
            |     .|:|:..|:     :.:..|.|... ||:.||:.|||.||.....||:    .|..|..
Mouse  1234 DAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLF----EYSANDT 1294

  Fly  2674 TIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVL 2738
            ..|.:
Mouse  1295 YTVQI------------------------------------------------------------ 1299

  Fly  2739 RSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSS 2803
                                               |...|.:||            |:..
Mouse  1300 -----------------------------------SPMSAFVDN------------HHEW----- 1312

  Fly  2804 IITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYR 2868
                                                 |:|.|:.:..|::...:||..|:.|||:
Mouse  1313 -------------------------------------FRFSGRILGLALIHQYLLDAFFTRPFYK 1340

  Fly  2869 WLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQ-----LDLDG 2928
                        .|:|:       |..|.||    ||:           .|:..|     .|.|.
Mouse  1341 ------------ALLRI-------LCDLSDL----EYL-----------DEEFHQSLQWMKDNDI 1371

  Fly  2929 CPIADLGL---DFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFD 2990
            ..|.||..   :.|.......||..||.:.|||..|..:||..:..|.:..||.:|.|:|..||.
Mouse  1372 HDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFY 1436

  Fly  2991 SVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH--GFHQDSQAIQYLYEILAS 3053
            .|...:.:.:|...|||.|..|:.        ||.:......|::  |:|.:...|::.:..:..
Mouse  1437 EVVDARLVSVFDARELELVIAGTA--------EIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVER 1493

  Fly  3054 YNRDEQRAFLQFVTGSPRLPTGGFKAL---TPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPD 3115
            :|.:::...||||||:..:|..||.:|   ..|    |:...|.......||...||.|.|.||.
Mouse  1494 FNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGP----RRFCVEKWGKITALPRAHTCFNRLDLPP 1554

  Fly  3116 YSSREVMRQKLKVAANEGS 3134
            |.|..::.:||..|..|.|
Mouse  1555 YPSFSMLYEKLLTAVEETS 1573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922	16/72 (22%)
		FAM199X	<1985..2074	CDD:292442	23/125 (18%)
		HECTc	<2818..3138	CDD:294058	86/330 (26%)
Hecw2	NP_001001883.1	HECW_N	45..164	CDD:374632
		C2_NEDL1-like	185..320	CDD:176073	4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..453		38/196 (19%)
		DMP1	<344..700	CDD:369294	102/545 (19%)
		NESP55	<463..639	CDD:115071	41/230 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..802		80/428 (19%)
		Interaction with TP73. /evidence=ECO:0000250	737..1074		80/452 (18%)
		WW	815..844	CDD:366073	4/28 (14%)
		HECW1_helix	921..987	CDD:375862	17/65 (26%)
		WW	993..1022	CDD:366073	7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1075		12/67 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1193		6/26 (23%)
		HECTc	1222..1576	CDD:238033	113/551 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900