DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ctrip and HUWE1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster


Alignment Length:3559 Identity:678/3559 - (19%)
Similarity:1086/3559 - (30%) Gaps:1298/3559 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 TATSATLANK--------TSGTNTTSASNHSSQRRRNNNTNSNRNKSHHKNEKRNAPATSGPAVS 80
            :.::.||.:|        ..|.|.:...|:::.....|...|..              |.|..::
  Fly  2443 SVSTTTLGSKRILFGSGGPGGPNASGNGNNTAGGSSGNGPGSGN--------------TYGTIIN 2493

  Fly    81 SSVDVVPATSTASATSTRRSRSQG-----RHSSAAALSSKESQIPKRSVGAIRSPSSPAFNS--I 138
            ..:....|..|...::..||.:.|     |......||.:            |......|||  :
  Fly  2494 RRLYPRLAARTGFGSAMERSNAMGGEHVLRDIIRNVLSDR------------RHAFEFIFNSDDM 2546

  Fly   139 PVVSDQSLSPGSRKRQLNQHNNSNNKASSSHQSAPGGDQLVCAPLKKRRLQQSLGSGICEGAVEI 203
            .|.|:.:.:|||                    ...||....          .|:|.|: .|:|..
  Fly  2547 AVDSEDAAAPGS--------------------GVGGGGSGA----------GSVGGGV-SGSVSG 2580

  Fly   204 NLGAASFDHTPRQASGDCVAQRTRSKTISPEELPSTSSAAAARHH----QIRPSAS--------- 255
            |..||..|....:::|        ..|..|....|::|:.|.:..    .:||..:         
  Fly  2581 NSSAAVIDVVEERSNG--------GDTNDPPANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFL 2637

  Fly   256 ------STSFSSSHRNKRKASIGGSIAAVETTPHRGTAAARAGRSGNLLNYYRKTRKVSHTRSSQ 314
                  ..|.|.........|:|.|.:..:...:...::..:|.:..:.|...:|.         
  Fly  2638 QSEGLRLASRSGGGAGSGSGSVGASSSGQQNGSNTTASSTNSGNNSGIGNLRLRTN--------- 2693

  Fly   315 KSEKQSIPAEDTTANRNGSAGSGSSSKSGVIPKNRKSLRHSQQNLLDTEAAEVESAAAETGGEQQ 379
                   |..| ..:.||| ||||.|.:||:..|         .:.....::..|.:::||....
  Fly  2694 -------PDVD-VGSGNGS-GSGSGSNAGVVNDN---------GISGGGGSDGASTSSDTGAPGG 2740

  Fly   380 SEHGNLDVIDQLPTPEAGPNQSEASGIHNQSQLEADRQPVVQDEDDEEDDEEEEEEEEEEVG--- 441
            :...|..::..:.|.|:..:.|    ..|..:.|.|     :||||:..||:.:|..|.:|.   
  Fly  2741 ARDLNASLLGDVSTSESDSDPS----TENDERNEED-----EDEDDDAPDEDVDEHSETDVDEER 2796

  Fly   442 ----------FYGIVNSAGSSYEEDTQIVAEEDEITTEEEVDDEDDDEIEEEDLSESEFAQQLIG 496
                      .|...:|..:|.:.|    .:.|:...|::|||:|||:.:.:|....|....:..
  Fly  2797 SRQFIEVFDHIYEPESSETASNDAD----VDNDDDDDEDDVDDDDDDDEDNDDDVREEVQSVMDA 2857

  Fly   497 ELGGERQQPQRATNNAKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAPGAGGGGPR 561
            |:                  .|...:|         .|..||..:.|     :.||..|.|.|  
  Fly  2858 EI------------------ENRIDIA---------LALVSSNNRPR-----RSAAVNASGDG-- 2888

  Fly   562 ATRSSNSNSSNNVV-------------DYSIMPHLTTVATTTPHALTPQQHQQQR----QPPQPP 609
               |:|..:.::.|             |..:.|      .:.|.|...:.:..:|    ..|.||
  Fly  2889 ---SANRTNPDDEVDDEDDDVDADPDGDPDVDP------ISGPSAAQAEAYLYERLGSGLMPTPP 2944

  Fly   610 SHQQQQVHQQQQPPQLLPTH-----------------QFAHLSSFVTPTAAAAAAAAAAHYPPAS 657
            ...:.:::.....|..:..:                 .....||....||:..|.|:||..|.:.
  Fly  2945 VGFRVRMNSSIAQPLDIDVNGGNAGSGSNAGATGSSGGSGQRSSTGGTTASIGAIASAALRPSSG 3009

  Fly   658 AAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHF-------TSTGAGPPP 715
            :..|                                        |..:|       :|.|:|  |
  Fly  3010 SWMA----------------------------------------PDFNFIRISGGDSSMGSG--P 3032

  Fly   716 ALFQQQAPPQLTRY-TPATATTAATFVPPQQQQV--VYNPQQQQHSSLRRSSRGKTGSCVSSAAA 777
            |:........:..: ||:.:...|...|...|.:  :.|.|.       ..:.|..|...:|...
  Fly  3033 AIGGNANGGDMNVFITPSMSLERAGGAPGSGQTMSELLNEQP-------TGAGGGGGGGSASGVG 3090

  Fly   778 AQQQQHHQQQQHSSAAA---AVQQQLLPPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQ-QQLA 838
            ..........||.:|..   .|:::||     |..||.    .|....||...::.|.:. .|.|
  Fly  3091 GVGANGGTTGQHPNATLCTNGVRRRLL-----YLDQQY----CVCMPTHQNPTEETQMETFTQDA 3146

  Fly   839 LHHQHQQQQHQQQQQQHQQQQHQQQQRATLVQPGFLFSY------RSNQPQQQQQPAQQIHQGPK 897
            ||...::......:.|..         |.|....||..:      .::|.::|::.|:|......
  Fly  3147 LHWWLEEATLLDMESQTD---------ACLYAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPAS 3202

  Fly   898 VTHSSAASDALTYSLMAQQPPSGPPHAGG---QQITPGANSANLSIVAAALSAARDVGGGSD--- 956
            .:::||.|.:.|..:....|.:....|.|   ..::.|:.|::|.:...|.||.    ||:.   
  Fly  3203 GSNASATSSSTTSVVGTAAPTATSSIASGLLANAVSAGSGSSSLVVPPVAASAT----GGTRRSS 3263

  Fly   957 ---------GGGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSNSNNVTATGSGSAPG 1012
                     |..||..||.|||..|:| ..|:..|..:.:.||.....||.:.  |.|......|
  Fly  3264 IPVLISSTLGPSSASSATSATGNGATS-DATTTTGGPTRNFSSVDSNVSSETQ--TTTRPPRQRG 3325

  Fly  1013 G------------------------GPTSTGTTSGT---------QHGSGSGAA-AAVDSESDDS 1043
            |                        |..||.||:||         ||.|.|.|| .||.......
  Fly  3326 GLRQQSQLPFNIYAEIDLTNEQDSEGDRSTSTTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHP 3390

  Fly  1044 EVGRLQALLEARGLP--PH---------LFGALGPRVTHILHRTIGNSSSSKAN----------- 1086
            .|    .||.:.|.|  ||         |......::.:.|..:.|:::||:.:           
  Fly  3391 PV----PLLPSSGRPSRPHTRLDETELLLLQLTDRQIRNRLQGSSGHTNSSRTSGSALINARPNR 3451

  Fly  1087 QLLQGLQSHDE---------SQQLQAAIEMCQMLVMGNEDTLAGFPIKQVVPALIQL-------L 1135
            .|...||.||.         |.....|            .||...|......||.||       :
  Fly  3452 DLPACLQRHDHPAGSIFPRPSANRTPA------------PTLVSMPTPMSNAALEQLNVTAPDVV 3504

  Fly  1136 RMEHNFDIMNNACRALAYMLEA----------LPRSS---------------------------- 1162
            |.:.||        ||...||.          ||:..                            
  Fly  3505 RTDRNF--------ALPSSLEVDVDVLPGIVDLPQQEAQPEDDQLLLPPPPPPPPSDTTPLVHAE 3561

  Fly  1163 -----GTVVEA-------VP-VFLEKLQVIQCMD------------------------------V 1184
                 ||||.|       .| |..|..:.:...:                              .
  Fly  3562 DDLWPGTVVSAGTREESSAPAVATESTEAVNESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAA 3626

  Fly  1185 AEQSLSALEILSRRHNKAILQANGISACLTYL-------------------DFFSIV-------- 1222
            .:.|:.|....:.....:...|:|.:|.:|.:                   .|.:.:        
  Fly  3627 VDASVGAQTPATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEV 3691

  Fly  1223 -------------AQRAALAIAANCCLNMHPEEFHFVAESLPL------LARLLSQQDKKCIESV 1268
                         ||:.|:.||.:..:.::||   |:| :|||      |.:...:|.::..::.
  Fly  3692 IQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPE---FLA-ALPLNIQSEVLMQQRIEQQRQAAQTA 3752

  Fly  1269 -------CSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTA---VVRMLSL 1323
                   .:||      ||:..:.|:|....|:.::  |:..:.|.:.....|..   ..|..:.
  Fly  3753 NPEDPVDTAAF------FQNLPENLRQAILTDMEES--QIASLPPELAAEAQFLRRDWESRNGAR 3809

  Fly  1324 MCCSCPDLAISLLRNDIA--------ATLLYLLTGNAEPAAASATHVELISRSPSELYELTCLIG 1380
            |....|..|:|..:..:.        :::.|..:|||:|  ....|..::.:.|...:       
  Fly  3810 MDAHPPSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQP--QHHQHTTIVHQHPHAHH------- 3865

  Fly  1381 ELMPRL--PLDGIFAVDS--LLDRPTLNT-------QDQ------VHWQWRDDRGSWHNYSTID- 1427
              .|.:  ||..:...|.  |||..:|.|       :||      :|   |..|...|:..|.| 
  Fly  3866 --APNMGKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLH---RVIRNLCHHEPTRDW 3925

  Fly  1428 --SRLIEAANQSSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLT 1490
              |.||.                        .:|:.|||           |.|:           
  Fly  3926 IISALIS------------------------IIQKTNED-----------NANF----------- 3944

  Fly  1491 TTSAGSAAAGGAS--TSAAAAAASSNNNN----NNNNNPPGNSVNLN----QVKRRPSLDARIAC 1545
                |:..|||..  ......||....:|    |........|:::|    |:..|..||     
  Fly  3945 ----GAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLD----- 4000

  Fly  1546 LKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHIA 1610
                          :..||.:.|.||..|..|....|.:|..|:.              :.|..|
  Fly  4001 --------------LLFVLAKHYPSSFVPFNRDVKARRILSAVFG--------------MPSPTA 4037

  Fly  1611 GMLGSNDLRIVVGALQMAEILMRQLPDV-------FGTHFRREGVIYQFTQLTDPNNPICANPSP 1668
            |..|.      .|:...|...:....||       |.:.|.|..|:.:...:.|.      :|:|
  Fly  4038 GSGGG------AGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDD------HPAP 4090

  Fly  1669 KPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNA 1733
            ||               |.|            :|.||..|.|                       
  Fly  4091 KP---------------SVP------------LDEAPSTSKA----------------------- 4105

  Fly  1734 LTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYF------VTQQGDPR-----QYV 1787
              |:||..      ||:..:|||..| ..|.|..::   |..|      :.||...|     |:.
  Fly  4106 --AAAKAA------ATAKVSTAGSQN-KHSVPYQTN---AKNFWDVVLNIDQQTQVRLANVAQFP 4158

  Fly  1788 HFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQ-----PHHQQPAHLVLASTSSGAASSSSSSS 1847
            ...|||....|...:.|.......||.:..:.|:     ||.......:|||.|:......... 
  Fly  4159 LTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEELL- 4222

  Fly  1848 SSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLS 1912
                      .::|.:....|.....::|          |.|.|...|...||:       |..:
  Fly  4223 ----------PLSDQMPPLVPIGPVQRAG----------AAAAAAHPPPPQPPA-------ENTA 4260

  Fly  1913 RATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKS-----SFLASLNPARWGRQTHQNH 1972
            .||.:|.|........:...||:.     |...||||:.::     |....:.|::..|:.:..:
  Fly  4261 TATEIGDGLAANIEEQASPASGNP-----ASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKN 4320

  Fly  1973 HHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASI------SK 2031
            .     ||.|                     |...|..|..|:..|..|.|.:..::      |.
  Fly  4321 F-----SQLQ---------------------LVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASS 4359

  Fly  2032 SISHANLLAA--ANRERARQWVREQAVDFVKRYTEQE---AKRSKAASESGATQSGSSGVGLSST 2091
            :|....|.||  ...|..||.: :..::.::.|...:   ...|:|||.|||..:.:|.|     
  Fly  4360 AIFIQYLTAAILGLAEEVRQAI-QMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYV----- 4418

  Fly  2092 GNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYM 2156
                 .|....::|..|:.                                  |.|:   |.:..
  Fly  4419 -----PTVSGASLLPNLAV----------------------------------HEGI---MQDRF 4441

  Fly  2157 TSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVH 2221
            |:|              ||....|     :|.  .||               |..||        
  Fly  4442 TAE--------------HVIISAP-----KNA--KPT---------------CELQL-------- 4462

  Fly  2222 DFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGY- 2285
              |:.....||.||..:|                 ||     |:||    .:|..:.|....|. 
  Fly  4463 --PSMKKLMSNSSAQPYF-----------------LR-----TLKI----FMQVRDMYEAQNGLS 4499

  Fly  2286 --GGI---RADSDDD-------------SEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMT 2332
              ||:   ..|:|||             |..||....|:.:..                 |..|.
  Fly  4500 TGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISP-----------------PPPME 4547

  Fly  2333 VYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSG 2397
            ..|..:.    ..:..|.|:|:.:..|                   |.:.|.|.|:.|:....|.
  Fly  4548 TNQIAQD----GDDDEEDDDEARSFPG-------------------VGNHAVASASKSTKPTLSQ 4589

  Fly  2398 VQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISAL 2462
            :           .|::.                                  ||:      .:|..
  Fly  4590 I-----------LCLDV----------------------------------LWN------TLSEC 4603

  Fly  2463 KPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANR 2527
            ...|..|.....|.|...:::|..:   |||.:|......|    ::.:|.:.....:..|.|. 
  Fly  4604 LVALEESKDEFAVLVLQPTVEAFFL---IHASHRGASKKSG----RSFMPNAAGFGLRAAAGAG- 4660

  Fly  2528 QLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFD-----RDRALQRLLDTTPDLNA 2587
                    ..|.|....|......||:....:.:....| |||     :|.:....|.|.|..:.
  Fly  4661 --------AIGGLGAAAPSAQEYSPFMDDVSSANTPSSA-SFDDEPRMQDASTNTPLVTNPSTST 4716

  Fly  2588 AESSERVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALV-- 2650
            |.|:.....|.||:|       .|:.||.      |...|.:|..::......||   |..||  
  Fly  4717 AMSAHEAQLRQDRQK-------FLQFAEK------HRTVLNQILRQSPTHLSDGP---FAVLVDH 4765

  Fly  2651 -------------SAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTP 2702
                         ..||:|.|.|:.....:.....||:            .||:....       
  Fly  4766 TRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTV------------FEDSFRVL------- 4811

  Fly  2703 AVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQ 2767
                                 ::..|....:|.:::..       :.....||.......::|::
  Fly  4812 ---------------------YRLGPEEWKNRFYIVFE-------DEEGQDAGGLLREWYVIISR 4848

  Fly  2768 QFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLP 2832
            :           |.||.......:.....|...|.|........||                   
  Fly  4849 E-----------IFNPMYALFCVSPGDRVTYMINPSSHANPNHLSY------------------- 4883

  Fly  2833 QMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQ 2897
                    |||:|:.:||||.|:::|:..|:..||:      |.:|        .:|::|.:..|
  Fly  4884 --------FKFVGRVIAKAVHDNKLLECYFTRSFYK------HILG--------KQVKHTDMESQ 4926

  Fly  2898 D--LVRQREYIL-SDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTV 2959
            |  ..:..:|:: :|.:....|.|...|..:.....|.||.              ..||||.||.
  Fly  4927 DYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLK--------------PNGRDTAVTE 4977

  Fly  2960 HNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEI 3024
            .|..:|:.||....:...:::|.:|..|||..:.|...:.:|..:|||.:..|..        :|
  Fly  4978 ENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLP--------DI 5034

  Fly  3025 KMLQESCRTD-HGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVR 3088
            .:......|: |.:...|..||:.:..|.|:::.::..|||||||:.::|..||.:|.....|.:
  Fly  5035 DIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQK 5099

  Fly  3089 KTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSF 3137
            ..:..:....|.||...||.|.|.||.|.|.:.:|..|..|.:|.|..|
  Fly  5100 FQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669 7/50 (14%)
WWE 1409..1481 CDD:128922 15/74 (20%)
FAM199X <1985..2074 CDD:292442 18/99 (18%)
HECTc <2818..3138 CDD:294058 85/324 (26%)
HUWE1NP_001285288.1 DUF908 90..326 CDD:283630
DUF913 621..989 CDD:283642
UBA_like_SF 1467..1506 CDD:304366
WWE 1756..1828 CDD:128922
40S_SA_C 3575..3651 CDD:292740 6/75 (8%)
DUF4414 3675..3779 CDD:291075 21/113 (19%)
HECTc 4796..5149 CDD:238033 102/474 (22%)
HECTc 4820..5148 CDD:214523 96/408 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.