DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and smurf1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001001943.1	Gene:	smurf1 / 321695	ZFINID:	ZDB-GENE-040426-2744	Length:	731	Species:	Danio rerio

Alignment Length:	304	Identity:	87/304 - (28%)
Similarity:	135/304 - (44%)	Gaps:	54/304 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  2841 FKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREY 2905
            |.|:|:.|..||.....::..|:||||:.|:.:  .|.|.||..|.||:..:||          :
Zfish   463 FHFVGRIMGLAVFHGHYINGGFTLPFYKQLLGK--PIQLCDLETVDPELHKSLV----------W 515

  Fly  2906 ILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGH------ANIELCRGGRDTPVTVHNLHQ 2964
            ||.:.....::.|..:|                    |      ...||...|::.|||..|..:
Zfish   516 ILENDITSVLDHTFCVE--------------------HNAFGKFLQHELKPNGKNIPVTEENKKE 560

  Fly  2965 YISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQE 3029
            |:.|...|..:.|::.||.||::||:.:.|...|:.|..:|||.:..|.|....:. |:.....:
Zfish   561 YVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLND-WKANTRLK 624

  Fly  3030 SCRTDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL------TPPLTIVR 3088
            .|..      ||..:::.::.:.|::.:.:...|||||||.|:|..|||||      ..|.....
Zfish   625 HCVA------DSNIVKWFWQAVESFDEERRGRLLQFVTGSTRVPLQGFKALQGSTGSAGPRLFTI 683

  Fly  3089 KTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANE 3132
            ..:|.|   .|.||...||.|.:.:|.|.|.|.:.:||..|..|
Zfish   684 HLIDAN---TDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	87/304 (29%)
smurf1	NP_001001943.1	C2_Smurf-like	14..138	CDD:176028
		WW	234..266	CDD:197736
		WW	280..312	CDD:197736
		HECTc	373..728	CDD:238033	87/304 (29%)
		HECTc	397..728	CDD:214523	87/304 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900