|
Fly 499 GGERQQPQRATNNAK---------------KTKNNTPAVAAASTIKA-----TTTATTSSGYQQR 543
||..::.||.|..|: |.|...|..:..|..|| .||:..|.|:..:
Rat 10 GGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKRKGYIPPESRKSNFKAPKVQSNTTSELSRGHLSK 74
Fly 544 AAPHGQGAAPGAGGGGPRATRSSNSNSSNNVVDYSIMPHLTTVATTTPHALTPQQHQQQRQPPQP 608
||.:|:|: .|:|. ...|......:.|:..|.|:.
Rat 75 --------------------RSCSSSSA------VIVPQ-----PEDPDRANTSERQKTGQVPKK 108
Fly 609 PSHQ------QQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQ 667
.:.: ....::...|........|.|:.|. :..:.||:.:
Rat 109 DNSRGVKRSASPDYNRTNSPSSAKKPRAFQHIESL-----------SETNKPPSKS--------- 153
Fly 668 HHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTGAGPPPALFQQQAPPQLTRYTPA 732
:.:|..|:|.::.||.|.....|:. .|..||...:..:::......:....
Rat 154 --KKRHLDQEQQLKSAQLPSTSKAHTR------------KSVAAGSSRSQKRKRTESSCVKSGSG 204
Fly 733 TATTAATFVPPQQQQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQ 797
:.:|.| ::....|.:....|...:..|.:....||:||:. ||:::||.
Rat 205 SESTGA-------EERSAKPTKLASKSATSAKAGCSTITDSSSAAST----------SSSSSAVA 252
Fly 798 QQLLPPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQH-- 860
. ..:||....|.:|...|.:.::.:.|.....::...:::|.:......
Rat 253 S--------------ASSTVPAGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFD 303
Fly 861 ---QQQQRATLVQPGFLFSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPP 922
:...:.:| |....|...:...:..:| ||....:..||...:....::.||:..|
Rat 304 WAARFSPKVSL--PKTKLSLPGSSKSETSKP------GPSGLQAKLASLRKSTKKRSESPPAELP 360
Fly 923 --HAGGQQITPGANSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVGASS 985
....:|.|.| :.|.::.|..|.|..|...| ......|...||...|.:|:
Rat 361 SLRRSTRQKTTG---------SCASTSRRGSGLGKRGAAEA----RRQEKMADPEGNQETVNSSA 412
Fly 986 SSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSESDDSEVGRLQA 1050
:....|.|.|:::|:...|.|. |||| :|||||||:|||||
Rat 413 ARTDEAPQGAAASSSVAGAVGM------------TTSG-------------ESESDDSEMGRLQA 452
Fly 1051 LLEARGLPPHLFGALGPRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGN 1115
|||||||||||||.||||::.:.|||||:.:||||.|||||||:.||||||||.|||||:|||||
Rat 453 LLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGN 517
Fly 1116 EDTLAGFPIKQVVPALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVEAVPVFLEKLQVIQ 1180
|:||.|||:|.||||||.||:|||||||||:|||||.||:|||||||..||:|:|||||||||||
Rat 518 EETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQ 582
Fly 1181 CMDVAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHF 1245
|:|||||:|:|||:|||||:||||||.|::.||.||:||||.|||.|||||||||.::.|:||||
Rat 583 CIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHF 647
Fly 1246 VAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILN 1310
||:|||||.:.|:.||||.:||.|..|.|||::|||:...|||:||.|||.|.||||:|||.||:
Rat 648 VADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILS 712
Fly 1311 TGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSELYEL 1375
:|.|..||||.||||.:||.||:.|::.:||.||.:||.|.:. .:....::|:.|||.|||||
Rat 713 SGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASN--GSCQEQIDLVPRSPQELYEL 775
Fly 1376 TCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIE-AANQSSE 1439
|.||.||||.||.:||||||::|.:......|...||||||||.||.|:.||||:|| ||:|..|
Rat 776 TSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQVGE 840
Fly 1440 DEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGAST 1504
|||||||.||.||:||::||||||||||.|.:||:.| |::
Rat 841 DEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPN-----PLA-------------------- 880
Fly 1505 SAAAAAASSNNNNNNNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYS 1569
|.|..|.| .:|:. |||...:||:..||..|||.:|.|||||||
Rat 881 ---------------NTNTSGYS----DLKKD---DARAQLMKEDPELAKSFIKTLFGVLYEVYS 923
Fly 1570 SSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQ 1634
|||||.||:|||||:||::|:|..|||:.|||...||||||.||.|.||:|||||||||||||::
Rat 924 SSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQK 988
Fly 1635 LPDVFGTHFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPF 1699
|||:|..:||||||::|...|.:..:.: |:.|.|...||.|.
Rat 989 LPDIFSVYFRREGVMHQVKHLAESESLL-----------TSPPKACTNGSGSL------------ 1030
Fly 1700 FMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYSSSA 1764
.||||:|| ||.:.|.:|
Rat 1031 ----------GSTTPASS----------------------GTATAATNA---------------- 1047
Fly 1765 PSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQPAH 1829
|:..|:|:.. |.:..:: :|.|.|
Rat 1048 -SADLGSPSLQ------------HSRDDSL-------DLSPQG---------------------- 1070
Fly 1830 LVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSG 1894
:::|:||||..||| |.|.
Rat 1071 ----------------------------RLSDVLKRKRLPKR----GPRR--------------- 1088
Fly 1895 PGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFLASL 1959
|..:||.......::..|..|: .|.||||||||
Rat 1089 PKYSPPRDDDKVDNQAKSPTTT--------------------------------QSPKSSFLASL 1121
Fly 1960 NPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAA 2024
||..|||.:.|: |||:......||:: ||..||
Rat 1122 NPKTWGRLSAQS--------------------NSNNIEPARTAGVS-------------GLARAA 1153
Fly 2025 VAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSSGVGLS 2089
...:||. |||:.:.|::|||..||:||...| :
Rat 1154 SKDTISN-----------NREKIKGWIKEQAHKFVERYFSSE----------------------N 1185
Fly 2090 STGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKAMLN 2154
..|:.| :.|||:||.:...:||.......:.|:|:::|:.|||:|.||:.|||.:|.:|.
Rat 1186 MDGSNP-----ALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLL 1245
Fly 2155 YMT--SETGLVERDARLRSFMHVFAGLPL---EPL--LQNVGQMPTIEPIAFGAFVAKLNGCVTQ 2212
|:| ||...|.|:.||:.|:|||...|| ||: ::.||..|.: |.|.|:|.|::|
Rat 1246 YLTSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHAPLL------ALVHKMNNCLSQ 1304
Fly 2213 LEQFPVKVHDFPAGPG-------GRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPL 2270
:|||||||||||:|.| .|.:| ||:|||||||||.|||||.|.|::|||||.||||||
Rat 1305 MEQFPVKVHDFPSGNGSGGSFSLNRGSQ-ALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPL 1368
Fly 2271 AMVQAIERYLVVRG---YGGIR---ADSDDD-SEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLP 2328
|:|||||||||||| ||.:| .||||| |:|::|:::||..|:..:.||:|||.||:|:||
Rat 1369 ALVQAIERYLVVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLP 1433
Fly 2329 YNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSS 2393
|||||||||:|||....::.|:.::....||.|.||.:.|||.|:||.|: ..||..
Rat 1434 YNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVRED---------EESSKD 1489
Fly 2394 CSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVV 2458
|..|.:.:..::.:.:|..|| :|..||||:|:.|.|
Rat 1490 CVGGKRGRAQTAPTKTSPRNA-----------------------------KKHDELWHDGVCPSV 1525
Fly 2459 ISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMA 2523
.:.|:.:|..: |.:.:|.:|.|||.:.:|||:||::|:|.:||...:.:.|||.|:||:.|:.|
Rat 1526 ANPLEVYLIPT-PPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTA 1589
Fly 2524 KANRQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAA 2588
||||||||||||||||:|.||.::|..|||.|||:||.:|||.|:||||||:||||||.|::|.:
Rat 1590 KANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQS 1654
Fly 2589 ESSE-RVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSA 2652
:|.: ||||||||:||.::|.|:|||||.::||.|.|:|:||||||||||||||||||||||||.
Rat 1655 DSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQ 1719
Fly 2653 ELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTT 2717
||||.|||||.|.: ||:
Rat 1720 ELQRADLGLWRGEE------VTL------------------------------------------ 1736
Fly 2718 TTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDN 2782
|:..|:.|.
Rat 1737 ---------------------------------SNPKGSQEG----------------------- 1745
Fly 2783 PSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKF 2847
|.|:..:.|||.||.|:::|...:.|.|.||:||||.
Rat 1746 ----------------------------TKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKL 1782
Fly 2848 MAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNI 2912
||||:||.|::|||..||||:|::.:|.|:...||..:.|.|..::..|:|:|||::.:..|.:.
Rat 1783 MAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQ 1847
Fly 2913 DAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEG 2977
........:|.|.::||.:.||||||.|||..||||.:||:|.|||:|||.:|:.||.:|.|.||
Rat 1848 TKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEG 1912
Fly 2978 VQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQ 3042
|.:||::.|:||:||||:..|:.||||||:.:.|||.:: .|:.|.|.|.||.|||:..||:
Rat 1913 VCRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKAD----TWDAKTLMECCRPDHGYTHDSR 1973
Fly 3043 AIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTC 3107
|:::|:|||:|::.::||.||||||||||||.|||::|.|||||||||.:..:||:|:|||||||
Rat 1974 AVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTC 2038
Fly 3108 VNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
|||||||||||.|:||.||.:||.||..|||||
Rat 2039 VNYLKLPDYSSIEIMRDKLLIAAREGQQSFHLS 2071
| 
