DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Hecw2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001101688.1	Gene:	Hecw2 / 316395	RGDID:	1593244	Length:	1578	Species:	Rattus norvegicus

Alignment Length:	1929	Identity:	357/1929 - (18%)
Similarity:	555/1929 - (28%)	Gaps:	773/1929 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1335 LLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSELYELTC--LIGELMPRLPLDGIFAVDSL 1397
            |.|..:...:|....|...||...:.:::.....||...|...  .:|.::      |:..|:..
  Rat   289 LERQAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPSSAQEDASPEAVGTIL------GVHTVNGD 347

  Fly  1398 LDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIEAAN-QSSEDEISLSTFGRTYTVDFHAMQQI 1461
            |..|   :.|:      |..||.|: |||      .|| ..|||.::..|...:    |.....:
  Rat   348 LGSP---SDDE------DMPGSHHD-STI------CANGPVSEDSVADGTPKHS----FRTSSTL 392

  Fly  1462 NEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAASSNNNNNNNNNPP-G 1525
            ..||                     :||.:||                         :.|:|| |
  Rat   393 EIDT---------------------EDLISTS-------------------------SRNSPPRG 411

  Fly  1526 NSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSS-----AGPNVRYKC----- 1580
            ...:||..     |||               |:|.........|||     |.|.:|...
  Rat   412 RQDSLNDY-----LDA---------------IEHNGPSRPGTASSSERPMGASPKLRSSFPTDTR 456

  Fly  1581 LRALLRMVYYATPELLRQVLKYQLVSSHIAGM-LGSNDLRIVVGALQMAEILMRQLPDVFGTHFR 1644
            |.|:|.:.........:|.|.|........|: :.|...||..|:|
  Rat   457 LNAMLHIDSDEEDHDFQQDLGYPSSLEEEGGLIMCSRTSRIDDGSL------------------- 502

  Fly  1645 REGVIYQFTQLTDP--NNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGL 1707
                    |..|.|  :||:      :...|:...||:.   :..|.:...::.......:||..
  Rat   503 --------TSQTKPEDDNPV------ENEDASVHETASL---EERPENLPEVEDGSLPSGTAPDE 550

  Fly  1708 SSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAP 1772
            :.||..|..|..|..:....|..::        .|:...||.:|.|:.|....:|...|...|:
  Rat   551 NEASVEPQPSADQGSTELCSSQEVD--------QPTSGTDAGASDTSVGSRRAASETESLDQGS- 606

  Fly  1773 AAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSS 1837
                     :|.|.....:|:.||              :.:.|.:...:|..:....
  Rat   607 ---------EPSQVSSETEPSDPA--------------RTESVSEASTRPEGESDLE-------- 640

  Fly  1838 GAASSSSSSSSSSSASALQHKMTDMLKRKAP--PKRKSQSGGRAKSRQEDAAVA--PAGSG---- 1894
             .|.||.:.|.::..|:::.:.:.:...:.|  |...||       .:||.|.|  |..||
  Rat   641 -GADSSCNESVTTQLSSVETRCSSLESARFPETPAFSSQ-------EEEDGACAAEPTSSGPTEG 697

  Fly  1895 -------PGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGS-GSSKSRFNAGNSSNAGSS 1951
                   ||..|.....|...|          |:|..:|..|..|. |....|    ..|..|::
  Rat   698 SQESVCTPGSLPAVQVPSREEE----------GSGAEATALSEQGELGEVWQR----RGSLEGAA 748

  Fly  1952 KSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGA--G 2014
            .::..|:.:                  ||.|..|   |.|::.  |:..||    |..:.||  |
  Rat   749 AAATAAATD------------------SQPQEDG---DPGDTQ--GACEGA----TAQEEGATGG 786

  Fly  2015 SGAGGLNAAAVAASISKSI-------------------SHANLLAAANRERARQWVR-------- 2052
            |...|........|:.:.:                   ||..:....:..|...|.|
  Rat   787 SQTNGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQ 851

  Fly  2053 --------EQAVDFVKRYTEQEAKRSKAASESGATQSGSSGVGLSSTGNTPLSTAGSTNVLERLS 2109
                    :|.....:||  |..:|:..........|...|.|..:..:...:.....|||...:
  Rat   852 VLQRSNSIQQMEQLNRRY--QSIRRTMTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHST 914

  Fly  2110 SILFKLNGSYHDCLDALLELKTILLESD-----ISP--FEVNHSG-----------LIKAMLNYM 2156
            |                ....|:||:|.     |||  |.|.||.           .:|.|:..:
  Rat   915 S----------------RSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKV 963

  Fly  2157 TSETGLVER---DARLRSFMHVFAGLPLEPLLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPV 2218
            ..:|...||   :..|..|:::||...||
  Rat   964 RRDTHHFERYQHNRDLVGFLNMFANKQLE------------------------------------ 992

  Fly  2219 KVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQA-------I 2276
                .|.|...:.:.....||..|..:.                 |..|||...:|:       :
  Rat   993 ----LPRGWEMKHDHQGKAFFVDHNSRT-----------------TTFIDPRLPLQSSRPTSALV 1036

  Fly  2277 ERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVK--Q 2339
            .|..:.|.    |:.|..:..||.              ||     .|..|||...:.:..|.  |
  Rat  1037 HRQHLTRQ----RSHSAGEVGEDS--------------RH-----AGPPVLPRPASTFNTVSRPQ 1078

  Fly  2340 FSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSS 2404
            :..:|   |...|:      ....:::|..|      .|:                  :|::|..
  Rat  1079 YQDMV---PVAYND------KIVAFLRQPNI------LEI------------------LQERQPD 1110

  Fly  2405 SSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSS 2469
            .:                           :.|....|....:||                    .
  Rat  1111 LA---------------------------RNHSLREKIQFIRTE--------------------G 1128

  Fly  2470 LPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLV 2534
            .|..|....||.|..|..|.....:              :.:|....:||.       ..|.|..
  Rat  1129 TPGLVRLSSDADLVMLLSLFEEEIM--------------SYVPPHALLHPS-------YCQSPRG 1172

  Fly  2535 IMTGNLPQWLPQIGMA-----CPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERV 2594
            ....: ||..|....|     .|:...||.:...||           |.|:|        .....
  Rat  1173 SPVSS-PQNSPGTQRANARAPAPYKRDFEAKLRNFY-----------RKLET--------KGYGQ 1217

  Fly  2595 APRLDRRKRAISRTEILKQAEHILQD-----FGHSKALLE-----IQYENEVGTGL-GPTLEFYA 2648
            .|         .:.:::.:.:|:|:|     .|:|:..|:     :.:..|.|... ||:.||:.
  Rat  1218 GP---------GKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFF 1273

  Fly  2649 LVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSS 2713
            |||.||.....||:    .|..|....|.:
  Rat  1274 LVSRELFNPYYGLF----EYSANDTYTVQI----------------------------------- 1299

  Fly  2714 TTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPA 2778
                                                                        |...|
  Rat  1300 ------------------------------------------------------------SPMSA 1304

  Fly  2779 AIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKF 2843
            .:||            |:..                                          |:|
  Rat  1305 FVDN------------HHEW------------------------------------------FRF 1315

  Fly  2844 LGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILS 2908
            .|:.:..|::...:||..|:.|||:            .|:|:       |..|.||    ||:
  Rat  1316 SGRILGLALIHQYLLDAFFTRPFYK------------ALLRI-------LCDLSDL----EYL-- 1355

  Fly  2909 DPNIDAMEKTEKIEQ-----LDLDGCPIADLGL---DFVLPGHANIELCRGGRDTPVTVHNLHQY 2965
                     .|:..|     .|.|...|.||..   :.|.......||..||.:.|||..|..:|
  Rat  1356 ---------DEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEY 1411

  Fly  2966 ISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQES 3030
            |..:..|.:..||.:|.|:|..||..|...:.:.:|...|||.|..|:.        ||.:....
  Rat  1412 IERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTA--------EIDLNDWR 1468

  Fly  3031 CRTDH--GFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL---TPPLTIVRKT 3090
            ..|::  |:|.:...|::.:..:..:|.:::...||||||:..:|..||.:|   ..|    |:.
  Rat  1469 NNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGP----RRF 1529

  Fly  3091 LDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGS 3134
            ..|.......||...||.|.|.||.|.|..::.:||..|..|.|
  Rat  1530 CVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETS 1573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922	16/72 (22%)
		FAM199X	<1985..2074	CDD:292442	23/125 (18%)
		HECTc	<2818..3138	CDD:294058	86/330 (26%)
Hecw2	NP_001101688.1	HECW_N	45..162	CDD:406866
		C2_NEDL1-like	185..321	CDD:176073	6/31 (19%)
		MDN1	<396..741	CDD:227596	95/508 (19%)
		NESP55	<464..632	CDD:115071	41/235 (17%)
		WW	815..844	CDD:395320	4/28 (14%)
		HECW1_helix	921..987	CDD:408233	17/65 (26%)
		WW	993..1024	CDD:197736	9/47 (19%)
		HECTc	1222..1576	CDD:238033	113/551 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900