DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and Arel1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001100214.1	Gene:	Arel1 / 299197	RGDID:	1307597	Length:	823	Species:	Rattus norvegicus

Alignment Length:	1075	Identity:	202/1075 - (18%)
Similarity:	344/1075 - (32%)	Gaps:	400/1075 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2140 PFEVNHSGLIKAMLNYMTSETGLVERDARLR-SFMHVFAGLPLEPLLQNVGQMP--TIEPIAF-- 2199
            |:||.||...:..|.|...:.....|...|| ...||...:.: |:.|.|.|.|  .:..:||
  Rat    69 PYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEI-PVTQEVLQEPNSNVVKVAFTV 132

  Fly  2200 ---GAF--VAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNLRQ 2259
               |.:  ..||.|.......: .|:  |..|....|....:..|:|..|.|. |.|
  Rat   133 RKAGRYEITVKLGGLNVAYSPY-YKI--FQPGMVVPSKTKIVCHFSTLVLTCG-QPH-------- 185

  Fly  2260 WKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGD 2324
                |::|.|                   |.:.|:.:...|            |.|.:..:::..
  Rat   186 ----TLQIVP-------------------RDEYDNPTNNSM------------SLREEHNYSLSI 215

  Fly  2325 HVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAAS 2389
            |.|                   .|:.:..||.                 ..|:.||        |
  Rat   216 HEL-------------------GPQEEENSEV-----------------SFEKSVT--------S 236

  Fly  2390 SSSSCSSGVQKQQSSSSSASSCV----------------------NATSSCSSSSGVASGGGSLT 2432
            :..:|...::....|.....:|:                      |......|:|||:....:..
  Rat   237 NRQTCQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSENEKNIVERNVSTSGVSIYFEAYL 301

  Fly  2433 KKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALC----------- 2486
            ..|:..||       ..||  :.|:.:|:     |...|:..:..::....:.|
  Rat   302 YNANSYSS-------APWH--LPPMHMSS-----SQRRPSTALEEEEEDSPSECHTPEKVKKPKK 352

  Fly  2487 ---------------MLRVIHALNRHWDHLYGCVVRQNIIPQSDF-------IHPKIMAKANRQL 2529
                           .|::|     .| .||    ...:.|.:.|       :|..:....:..:
  Rat   353 VYCYVSPKQFSVKEFYLKII-----PW-RLY----TFRVCPGTKFSYLGPDPVHKLLTLVVDDGI 407

  Fly  2530 QDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERV 2594
            |              |.:.::|      :.|::|  |.:|  .|:|.:      ::..:|:.:..
  Rat   408 Q--------------PPVELSC------KERNIL--AATF--IRSLHK------NIGGSETFQDK 442

  Fly  2595 APRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDL 2659
            .....|..|.:          |:.:.  |||..|::..              :||:.:.|:.|
  Rat   443 VNFFQRELRQV----------HMKRP--HSKVTLKVSR--------------HALLESSLKAT-- 479

  Fly  2660 GLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQH 2724
                       .:.:|.|..|....|...|:||     |...|......|:..:...||:.
  Rat   480 -----------RNFSISDWSKNFEVVFQDEEAL-----DWGGPRREWFELICKALFDTTSQ---- 524

  Fly  2725 QHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSA--NPAAIDNPSSTT 2787
                                                    :..:|||.|.|  :|    ||
  Rat   525 ----------------------------------------LFTRFSDNNQALVHP----NP---- 541

  Fly  2788 TATTVVQHNTTTNNSSIITTTTTTSYVHAVHG--LFPLPLGKSSKLPQMTKAKAKFKFLGKFMAK 2850
                         |...........:...:.|  |:...||.:.|  |:.:|    :|...|:|:
  Rat   542 -------------NRPAHLRLKMYEFAGRLVGKCLYESSLGGAYK--QLVRA----RFTRSFLAQ 587

  Fly  2851 AVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLV--RLQDLVRQREYILSDPNID 2913
             ::..||        .|::..:::            ||...:.|  .|.:.:.:.|.:.::
  Rat   588 -IIGLRM--------HYKYFETDD------------PEFYKSKVCFILNNDMSEMELVFAE---- 627

  Fly  2914 AMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGV 2978
              ||..|..|||                  ..:||..||..||||..|...|::|:..:.|...|
  Rat   628 --EKYNKSGQLD------------------KIVELMTGGAQTPVTNANKTFYLNLLAQYRLASQV 672

  Fly  2979 QKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH------GF 3037
            :::.|...:|.:.:.|...|.:|...|||.:.||:|.           :..|....|      .:
  Rat   673 KEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGD-----------ISVSDFKAHAVVVGGSW 726

  Fly  3038 HQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLP 3102
            |...:.:::.:.:::|..::|....|||.|||.:||.|||.||.|...|:...      .:..||
  Rat   727 HFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAP------THSTLP 785

  Fly  3103 SVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSF 3137
            :..||.|.|.||.|.|.|.:.:.|::|.:||...|
  Rat   786 TAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	84/330 (25%)
Arel1	NP_001100214.1	Filamin	56..154	CDD:395505	23/85 (27%)
Arel1	NP_001100214.1	HECTc	486..820	CDD:214523	103/471 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900