DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and Bag3

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	414	Identity:	85/414 - (20%)
Similarity:	129/414 - (31%)	Gaps:	125/414 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 QPHYYHSSVAVLHQPPPHHFTSTGAGPPPALFQQQAPPQLTR---------YTPATATTAATFVP 742
            |||.:|:    ..||....|.:..|...|...|......:|.         ..||||||||.
Mouse   109 QPHLFHA----YSQPGVQRFRTEAAAATPQRSQSPLRGGMTEAAQTDKQCGQMPATATTAAA--- 166

  Fly   743 PQQQQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQQQLLPPPGTY 807
              |....:.|:        ||.......|.||:::|...        ||..:::....||
Mouse   167 --QPPTAHGPE--------RSQSPAASDCSSSSSSASLP--------SSGRSSLGSHQLP----- 208

  Fly   808 QYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQ---HQQQ------ 863
                  ...:.:.|.|:|.:.:...|..    .||.|:..:..||.::|.||   |:.|
Mouse   209 ------RGYIPIPVIHEQNITRPAAQPS----FHQAQKTHYPAQQGEYQPQQPVYHKIQGDDWEP 263

  Fly   864 ----QRATLVQPGFLFSYRSNQPQQQQQPAQ-----QIH------------QGPKVTHSSAASDA 907
                ..:....|....|.|...|.:...|..     ::|            :.|.||
Mouse   264 RPLRAASPFRSPVRGASSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREPPPVT-------- 320

  Fly   908 LTYSLMAQQPPSGPPHAGGQQITPGANSANLSIVAAALSA-ARDVGGGSDGGGSAGGATPATGAS 971
                 ..:..|...|...|..:.||    ::.|......| ::.|        |.....||....
Mouse   321 -----QPENKPESKPGPAGPDLPPG----HIPIQVIRREADSKPV--------SQKSPPPAEKVE 368

  Fly   972 ASSVGNTSAVGASSSSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAV 1036
            .    ..|:......|.|.|..|..|...||.|. ..:||...|..            ..|..:.
Mouse   369 V----KVSSAPIPCPSPSPAPSAVPSPPKNVAAE-QKAAPSPAPAE------------PAAPKSG 416

  Fly  1037 DSESDDSEVG--RLQALLE-ARGL 1057
            ::|:.....|  :::|:|| .:||
Mouse   417 EAETPPKHPGVLKVEAILEKVQGL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	10/51 (20%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		WW	23..55	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		22/101 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		44/243 (18%)
		BAG	426..503	CDD:214591	6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900