DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Nedd4l

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	1613	Identity:	298/1613 - (18%)
Similarity:	488/1613 - (30%)	Gaps:	614/1613 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1768 SSGAPAAYFVTQQGDPRQYVHFQ---QPAVPAPPPQQELLPSGVQQ--------QGQQVPQVIYQ 1821
            |:.||.:..:.|:.:...::.||   :.:.|.|..|.....||:|:        ....:||::
  Rat    14 SNTAPESEILDQEREEDFFMAFQTLPRRSSPHPFTQNAGEDSGLQEGVGALKRSSSMFIPQLL-- 76

  Fly  1822 PHHQQPAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKA---------PPKRKSQSGG 1877
                             |...:..:.|||...:||.|..|......         ||..:...|.
  Rat    77 -----------------AGVDARPTRSSSMKISLQRKAADGATDSCGPQEGPDDRPPSAQGDLGD 124

  Fly  1878 RAKSRQEDAAV-----APAGSGPGGAPPSS--------SGSAMH------------------ELL 1911
            :|.:.:..|.:     :|..: ||.:||.:        :|:..|                  .:.
  Rat   125 QAAATRVSAQIGSSEPSPVDT-PGSSPPRAAWDPGTLVNGTCDHRGPSPRLAEDTEEATPGLRIQ 188

  Fly  1912 SRATS--------LGSGNGGRS---------TPNSGGGSGS----------SKSRFNAGNSSNAG 1949
            .||:|        |..|..|::         .|::.|.||.          .:.....|:..|.|
  Rat   189 HRASSADVRQVRLLPFGPDGQAEPRRWSLQHVPDASGSSGKRCFVFQLQQPHQGTVGLGSDFNFG 253

  Fly  1950 --SSKSSFLASLNPARWGRQT-HQNHHHHHQQSQQQHHGLSKDS--------GNSNSTGSGSGAG 2003
              .:|...|......|..|.| :.......:.|..:..|..:.|        ..:||..:....|
  Rat   254 FTGTKGDRLVRYPRIRLERSTSYPTQPRAGRVSPTEDRGTPEASPRRMVPEIRRTNSERTPQSPG 318

  Fly  2004 LAYTVSQ-HGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEA 2067
            ..:.:.| ..||.                  .|..:|.....|.|.|             .::|.
  Rat   319 CMFKIRQDQNAGQ------------------QHFRILVTRGPEEAPQ-------------NQEET 352

  Fly  2068 KRSKAASESGATQSGSSGVGLSSTG------NTPLSTAGSTN-VLERLSSILFKLNGSYHDCLDA 2125
            .:|          .|..|.|:.:..      :.|||...:.: .:||  ...||         |.
  Rat   353 PKS----------PGHPGTGVPTRDDFLGQVDVPLSHLPTEDPTMER--PYTFK---------DF 396

  Fly  2126 LLELKTILLESDISPFEVNHSGLIKAMLN----YMTSETGLVERDARLRSFMHVFAGLPLEPLLQ 2186
            ||..:             :|...:|..|.    ||....|..|.::..|..|.
  Rat   397 LLRPR-------------SHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDME------------ 436

  Fly  2187 NVGQMPTIEPIAFGAFVAKLNGCVTQ-LEQFPVKVHDFPAGPGGRSNQSAL--RFFNTHQLKCNL 2248
                        .|..|...|...:| .|:.|..    |..||.......|  .::..|..:...
  Rat   437 ------------HGWEVVDSNDSASQHQEELPPP----PLPPGWEEKVDNLGRTYYVNHNNRSTQ 485

  Fly  2249 QRHPQC--------NNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEE------- 2298
            ...|..        ||:||          :....|..|:   |....|..|.:.::.|
  Rat   486 WHRPSLMDVSSESDNNIRQ----------INQEAAHRRF---RSRRHISEDLEPEASEGGGEGPE 537

  Fly  2299 -----DMDDNVAAVVLSQA-------------------SFRHKLQFTIGDHVLPYNMTVYQAVKQ 2339
                 ..:.|:|...||.|                   ....:||.|...:           .:|
  Rat   538 PWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSN-----------GEQ 591

  Fly  2340 FSPLVSEQPE--------TDNESE---------------------------------TLLGNASI 2363
            ||.|:..:|.        ||..:|                                 |..|..|.
  Rat   592 FSALIQREPSSRLRSCSVTDTVAEQAHLPPPSTPTRRARSSTVTGGEESTPSVAYVHTTPGLPSG 656

  Fly  2364 WVQQH---------------TIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVN 2413
            |.::.               |...||:.:....||:..|.:|::.......::..|.||.:..::
  Rat   657 WEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLS 721

  Fly  2414 A--------------TSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKP 2464
            |              ..:.|:.........:..|..||.:..|:...   |...|||    ..:|
  Rat   722 APLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPG---WEMRIAP----NGRP 779

  Fly  2465 FLSSSLPADVVTVQDASLDALCMLRVIHALNRH--------WD---HLYGCVVRQNIIPQSDFIH 2518
            |.... .....|.:|..|.....:|...:||.:        |:   ||.|   |...|..|.
  Rat   780 FFIDH-NTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDG---RTFYIDHSS--- 837

  Fly  2519 PKIMAKANRQLQDPLVIMTGNLPQW------LPQI-GMACPFLFPFETRHLLFYATSFDRDRALQ 2576
             :::...| ..::.:.:....:.||      .|.| |.|.|:...|:.::..|       .:.|:
  Rat   838 -QVLCGEN-DTRESVPLYDSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYF-------RKKLK 893

  Fly  2577 RLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLG 2641
            :..|.............:.....||..::.|.::|             ||.|.|::|:|.|...|
  Rat   894 KPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL-------------KARLWIEFESEKGLDYG 945

  Fly  2642 PTL-EFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVA 2705
            ... |::.|:|.|:.....||:                              |.:.||..|
  Rat   946 GVAREWFFLLSKEMFNPYYGLF------------------------------EYSATDNYT---- 976

  Fly  2706 GASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFS 2770
                                                     ::.:.:|...||:.|
  Rat   977 -----------------------------------------LQINPNSGLCNEDHL--------- 991

  Fly  2771 DTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMT 2835
                                                     ||
  Rat   992 -----------------------------------------SY---------------------- 993

  Fly  2836 KAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLV 2900
                 |.|:|:....||...::||..|..|||:.::.::  |.|.|:..|..|..|:|
  Rat   994 -----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSEYYNSL------- 1044

  Fly  2901 RQREYIL-SDPNIDAMEKTEKIEQLDLDGC-PIADLGLDFVLPGHANIELCRGGRDTPVTVHNLH 2963
               ::|| :||.           :|||..| ...:.|..:      .::|...|.:..||..|..
  Rat  1045 ---KWILENDPT-----------ELDLMFCIDEENFGQTY------QVDLKPNGSEIMVTNENKR 1089

  Fly  2964 QYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSE-----QQHSRWE 3023
            :||.||..|..:..||||..|..|||..:.||..:::|...|||.:.||.|..     :|||.::
  Rat  1090 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYK 1154

  Fly  3024 IKMLQESCRTDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL----TPPL 3084
                       :|:..:...||:.::.:...:.:::...||||||:.|:|..||..|    .|.|
  Rat  1155 -----------NGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQL 1208

  Fly  3085 TIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSF 3137
            .    |:::..:| :.||...||.|.|.||.|.:.|.:|:||.:|. |.:..|
  Rat  1209 F----TIEQWGSP-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	15/97 (15%)
		HECTc	<2818..3138	CDD:294058	91/331 (27%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471	13/76 (17%)
		WW	463..489	CDD:395320	3/25 (12%)
		WW	653..682	CDD:395320	3/28 (11%)
		WW	766..796	CDD:238122	8/37 (22%)
		WW	815..865	CDD:197736	10/57 (18%)
		HECTc	926..1255	CDD:214523	115/539 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900