DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Hecw1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_017455974.1	Gene:	Hecw1 / 291209	RGDID:	1561038	Length:	1603	Species:	Rattus norvegicus

Alignment Length:	1549	Identity:	287/1549 - (18%)
Similarity:	452/1549 - (29%)	Gaps:	561/1549 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1664 ANPSPKPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTTPSSSKHQSYSVKSFS 1728
            :.|...|:|...|..|:|.|....|.: :.::::. .:.|.|.....|||......:..|....|
  Rat   533 SRPCSLPVSELETVIASACGEAETPRT-HYIRIHT-LLHSMPSAQRGSTTEEEDAMEEESTLKES 595

  Fly  1729 HAMNALT----------ASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVTQQGDP 1783
            ...:.|:          :...|..:||....:||..:||: :|:.:.|..:|        |.|:
  Rat   596 SEKDGLSEVDTIAADPQSMEDGENNGATLCMASSDCSGGH-FSNLSKSIGAG--------QDGE- 650

  Fly  1784 RQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASSSSSSSS 1848
                     |.|:...:.:..|    |||..        |..:.......|.|..:.|..|||..
  Rat   651 ---------AHPSTGSESDSSP----QQGAD--------HSCEGCDASCCSPSCYSTSCYSSSCY 694

  Fly  1849 SSS-------------ASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAA---VAPAGSGPGG 1897
            |||             ||..:....|..|........||.    ...:|::|   |..:...|..
  Rat   695 SSSCYSSSCYNGNNRFASHTRFSSVDSAKISESTVFSSQE----DEEEENSAFESVPDSVQSPEL 755

  Fly  1898 APPSSSGSA--MHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFLASLN 1960
            .|.|::|:.  ..||     :...||..|:|...........:|..........|...|.|.||.
  Rat   756 DPESTNGAGPWQDEL-----AAPGGNAARTTEGLDSPMAGPSNRREGDCPMLHNSQPISQLPSLR 815

  Fly  1961 PARWGRQTHQNHHHH---------HQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSG 2016
            |         .|||:         :.:::...||......:.|.|.:.....:|.|..
  Rat   816 P---------EHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPSMAPTPD------- 864

  Fly  2017 AGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQS 2081
             |.:.:.:|......:..:.|:......||:.:....|:.:.:              .:.||...
  Rat   865 -GMIRSGSVHQMEQLNRRYQNIQRTIATERSEEDSGNQSCEQI--------------PDGGAGGG 914

  Fly  2082 GSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHS 2146
            ||.....||..|..|...||          |..:|.          :..|:||:|....|..|..
  Rat   915 GSDSEAESSQSNLDLRREGS----------LSPVNS----------QKVTLLLQSPAVKFITNPE 959

  Fly  2147 GLIKAMLNY-----MTSETGL------VERDAR----------LRSFMHVFAGLPLEPLLQNVGQ 2190
            .......||     .||.|.|      |.||||          |.:|:::||...||
  Rat   960 FFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE-------- 1016

  Fly  2191 MPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCN 2255
                                            .|.|...:::.....||..|..:
  Rat  1017 --------------------------------LPRGWEIKTDHQGKSFFVDHNSR---------- 1039

  Fly  2256 NLRQWKGGTVKIDPLAMVQ--AIERYLVVRGY-GGIRADSDDDSEEDMDDNVAAVVLSQASFRHK 2317
                   .|..|||...:|  .:..:|..|.: ..:|:.|..::.| :..|..|.:|::..  |.
  Rat  1040 -------ATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASE-VSRNRGASLLARPG--HS 1094

  Fly  2318 LQFTI-GDH-----VLPYNMTVYQAVKQ---FSPLVSEQPETDNESETLLGNASIWVQQHTIHYR 2373
            |...| ..|     .|.||..:...::|   |..|...||       :|..|.::   :..|||.
  Rat  1095 LIAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQP-------SLARNHTL---REKIHYI 1149

  Fly  2374 PVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKS 2438
            ..|.                 :.|::|               .||.:.
  Rat  1150 RTEG-----------------NHGLEK---------------LSCDAD----------------- 1165

  Fly  2439 SSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYG 2503
                            ..:::|..:..:.|.:|.........|....|.               .
  Rat  1166 ----------------LVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCS---------------P 1199

  Fly  2504 CVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFY--- 2565
            |...||        .|.:...:.|                     ...|:...||.:...||
  Rat  1200 CSSPQN--------SPGLQRASAR---------------------APSPYRRDFEAKLRNFYRKL 1235

  Fly  2566 -ATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLE 2629
             |..|.:.....:|:.....|.....::.:         |.||.|:.:..             |.
  Rat  1236 EAKGFGQGPGKIKLIIRRDHLLEGTFNQVM---------AYSRKELQRNK-------------LY 1278

  Fly  2630 IQYENEVGTGL-GPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALE 2693
            |.:..|.|... ||:.||:.|:|.||.....||:    .|..|....|.:...::.|
  Rat  1279 ITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLF----EYSANDTYTVQISPMSAFV-------- 1331

  Fly  2694 ATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANE 2758
                                                                            |
  Rat  1332 ----------------------------------------------------------------E 1332

  Fly  2759 NALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPL 2823
            |.|..
  Rat  1333 NYLEW------------------------------------------------------------ 1337

  Fly  2824 PLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPE 2888
                             |:|.|:.:..|::...:||..|:.|||:.|:  :....|:||..:..|
  Rat  1338 -----------------FRFSGRILGLALIHQYLLDAFFTRPFYKGLL--KLPCDLSDLEYLDEE 1383

  Fly  2889 VQNTLVRLQDLVRQREYILSDPNI-DAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGG 2952
            ...:|           ..:.|.|| |.::.|..:.              :.|.......||..||
  Rat  1384 FHQSL-----------QWMKDNNITDILDLTFTVN--------------EEVFGQVTERELKSGG 1423

  Fly  2953 RDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQ 3017
            .:|.||..|..:||..:..|.:..||.:|.|||..||..|...:.:.:|...|||.|..|:.
  Rat  1424 ANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTA--- 1485

  Fly  3018 QHSRWEIKMLQESCRTDH--GFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL 3080
                 ||.:......|::  |:|.....|::.:..:..:|.:::...||||||:..:|..||.||
  Rat  1486 -----EIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAAL 1545

  Fly  3081 TPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGS 3134
            ... ..:|:...|.......||...||.|.|.||.|.|...:.:||..|..|.|
  Rat  1546 RGS-NGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEETS 1598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	11/88 (13%)
		HECTc	<2818..3138	CDD:294058	83/320 (26%)
Hecw1	XP_017455974.1	HECW_N	66..185	CDD:293170
		C2_NEDL1-like	206..342	CDD:176073
		WW	827..857	CDD:197736	4/29 (14%)
		WW	1017..1048	CDD:197736	9/47 (19%)
		HECTc	1247..1601	CDD:238033	110/563 (20%)
		HECTc	1271..1600	CDD:214523	105/530 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900