DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and HERC4

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	686	Identity:	135/686 - (19%)
Similarity:	241/686 - (35%)	Gaps:	177/686 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2518 HPKIMAKANRQLQDPLV-IMTGNLPQ--------WLPQIGMACPFLFP---FETRHLLFYATSFD 2570
            ||:|..:....|:..|: .:|.:||.        .||:    ||.:..   |.|..:.|.....:
Human   499 HPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPE----CPLMSDSNNFTTIAIPFGTALVN 559

  Fly  2571 RDRALQRLLDT-----TPD--LNAAESSERVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALL 2628
            .::|..::|:.     .|.  |...|..:.|...|.:    :.:..|......|...|.|: ||.
Human   560 LEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLK----LYKIGIPPSERRIFNSFLHT-ALK 619

  Fly  2629 EIQYENEVGTGLGPTLEFYALVSAELQ-----RTDLGLWNGSDSY----KQNSVTIVDVVKANSA 2684
            .::..:.|...:|..:::......|:|     |.|...|....:|    ......:.|:......
Human   620 VLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICT 684

  Fly  2685 VLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEH 2749
            ...:.|| :|.||...|.||....:...         |.|:.
Human   685 YPFVFDA-QAKTTLLQTDAVLQMQMAID---------QAHRQ----------------------- 716

  Fly  2750 SSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSY- 2813
                   |.::|.:.:.:      |.||..|         ..|.:.|...:...::..|....|
Human   717 -------NVSSLFLPVIE------SVNPCLI---------LVVRRENIVGDAMEVLRKTKNIDYK 759

  Fly  2814 ------------------------------VHAVHGLFPLPLGKSSKL----PQMTKAKAKFKFL 2844
                                          :...:|:|  ...:.|:|    .:..:....|..:
Human   760 KPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMF--RYYEDSRLIWFSDKTFEDSDLFHLI 822

  Fly  2845 GKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSD 2909
            |.....|:.:..::||.|.|..|:.|:.::.|  |.||..:.|:|..::.:|.|...
Human   823 GVICGLAIYNCTIVDLHFPLALYKKLLKKKPS--LDDLKELMPDVGRSMQQLLDYPE-------- 877

  Fly  2910 PNIDAMEKTEKIEQLDLDGCPIADLGLDFVLP----GHANI-ELCRGGRDTPVTVHNLHQYISLV 2969
               |.:|:|               ..|:|.:.    |...: ||...|.||.|...|..:::...
Human   878 ---DDIEET---------------FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 924

  Fly  2970 TYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTD 3034
            ..:...:.|...|:|...||..|...:.|.:|.|.||:.:..|      ::.::.|.|:::....
Human   925 VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG------NTNYDWKELEKNTEYK 983

  Fly  3035 HGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPND 3099
            ..:..:...|:..:|:......::::.||.|:|||.|:|..|.|:|       :..:.......:
Human   984 GEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGEE 1041

  Fly  3100 YLPSVMTCVNYLKLPDYSSREVMRQKL--KVAANEG 3133
            |||...||.|.|.||.|:.:|.:|.||  .:..|||
Human  1042 YLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEG 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	78/327 (24%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	83/397 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900