DRSC/TRiP Functional Genomics Resources

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Protein Alignment ctrip and MAGI3

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:NP_001136254.1 Gene:MAGI3 / 260425 HGNCID:29647 Length:1481 Species:Homo sapiens


Alignment Length:601 Identity:118/601 - (19%)
Similarity:178/601 - (29%) Gaps:226/601 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SVKSQSLSALTEGQHD-------DGGSTATSATLANK-----TSGTNTT-------------SAS 43
            :|..||:..|:   ||       |.|.|.|...:|.:     .||||:.             |.:
Human   905 AVNGQSIVELS---HDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQA 966

  Fly    44 NHSSQRR--------RNNNTNSNRNKSHHKN-------------------------EKRNAP--- 72
            ||....|        ::.:|:...:.|.||:                         |....|   
Human   967 NHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGF 1031

  Fly    73 -------------------ATSGPA-------VSSSVDVVPATSTASATSTRRSR--SQGRHSSA 109
                               |..|||       |...:..:....|...|.||...  ..|.:...
Human  1032 GFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1096

  Fly   110 AALSSKESQIPKRSVGAIRSPSSPAFNSIPVVSDQS-LSPGSRKRQLNQHNNSNNKASSSHQSAP 173
            ..|......||......|.:|||    |..:..:|| |.|.|....:.:         .||    
Human  1097 LLLRPGTGLIPDHGDWDINNPSS----SNVIYDEQSPLPPSSHFASIFE---------ESH---- 1144

  Fly   174 GGDQLVCAPLKKRRLQQSLGSGICEGAVEINLGAASFDHTPRQAS------GDCVAQRTRSKTIS 232
                   .|:    :::||...|||.|.|:.      |..|.:.|      .:...|....|.:|
Human  1145 -------VPV----IEESLRVQICEKAEELK------DIVPEKKSTLNENQPEIKHQSLLQKNVS 1192

  Fly   233 PEELPST------------SSAAAARHHQIRPSASSTSFSSSH-------------RNKRKASIG 272
            ..:.||:            .:....|...:.|...::..|..|             |..|..|: 
Human  1193 KRDPPSSHGHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSL- 1256

  Fly   273 GSIAAVETTPHRG-----TAAARAGRSGNLLNYYRKTR-KVSHTRSSQKSEKQSIPA-------E 324
                    :|.:|     ..:.||| ||.  :..||:| :.:..:..||.|....|:       |
Human  1257 --------SPSKGENKSCQVSTRAG-SGQ--DQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLE 1310

  Fly   325 DTTANRNGSAGSGS------SSKSGVIPKN----------------------RKSLRHSQQN-LL 360
            ..:....|..||.:      ..||.||.|:                      .|||.....| ..
Human  1311 GKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKRMVEKSLPSKMTNKTT 1375

  Fly   361 DTEAAEVESAAAETGGEQQSEHGNLDVIDQLPTPEAGPNQSEASGIHNQSQLEADRQPVVQDEDD 425
            ..|.:|.|.....|.||..|.:..:....||         ||     .:.:.|.:.:.|....:|
Human  1376 SKEVSENEKGKKVTTGETSSSNDKIGENVQL---------SE-----KRLKQEPEEKVVSNKTED 1426

  Fly   426 EEDDEEEEEEEEEEVG 441
            .:..|.|..::.:|.|
Human  1427 HKGKELEAADKNKETG 1442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922
FAM199X <1985..2074 CDD:292442
HECTc <2818..3138 CDD:294058
MAGI3NP_001136254.1 Interaction with ADRB1 and TGFA. /evidence=ECO:0000250 18..106
PDZ_signaling 24..101 CDD:238492
NK 123..>197 CDD:327404
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..273
WW 294..326 CDD:197736
WW 342..372 CDD:238122
Interaction with PTEN. /evidence=ECO:0000269|PubMed:10748157 410..492
PDZ 413..493 CDD:214570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..570
PDZ 575..656 CDD:214570
Interaction with ADGRB1. /evidence=ECO:0000269|PubMed:10748157 726..808
PDZ_signaling 726..807 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..843
PDZ_signaling 849..935 CDD:238492 10/32 (31%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269|PubMed:10748157, ECO:0000269|PubMed:16904289 851..938 11/35 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 8/36 (22%)
PDZ_signaling 1022..1100 CDD:238492 12/77 (16%)
Red1 <1132..1461 CDD:311769 72/367 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1170..1481 58/299 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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