DRSC/TRiP Functional Genomics Resources

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Protein Alignment ctrip and HECTD1

DIOPT Version :10

Sequence 1:NP_649496.3 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:NP_056197.3 Gene:HECTD1 / 25831 HGNCID:20157 Length:2610 Species:Homo sapiens


Alignment Length:2837 Identity:549/2837 - (19%)
Similarity:912/2837 - (32%) Gaps:1024/2837 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1089 LQGLQSHDESQQLQAAIEMCQMLVMGN--EDTLAGFPIKQVVPALIQLLRMEHNFD-IMNNACRA 1150
            ||..|..:...||.|..::|.:|:|.:  :......|.:..:|||.::...|...| ::....||
Human    13 LQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDESAPDNVLEVTARA 77

  Fly  1151 LAYMLEALPRSSGTVV---EAVPVFLEKLQVIQ-----CMDVAEQSLSALEILSRRHNKAILQAN 1207
            :.|.|:.....:..:|   .|:.....:|.|::     ..|:|||.:..||::..|.:.|:.:|.
Human    78 ITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELICTRESGAVFEAG 142

  Fly  1208 GISACLTYL-DFFSIVAQ---RAALAIAANCCLNMHPEE--FHFVAESLPLLARLLSQQDKKCIE 1266
            |::..||:: |...:|.:   .:|:|:.:..|..|.|::  .....||   |:.||..:|.:..:
Human   143 GLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVES---LSSLLKHEDHQVSD 204

  Fly  1267 SVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVT------------PAILNTGT------ 1313
            .....|..|.:.|...|.....:|...|.:.....:...            |....||.      
Human   205 GALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGGTVSGPSSACKPGRSTTGAPSTTAD 269

  Fly  1314 ------FTAVVRMLSLMCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSEL 1372
                  .:.:|.:||.:|...|.:...|||:::..::...|.|:......:...|:|        
Human   270 SKLSNQVSTIVSLLSTLCRGSPVVTHDLLRSELPDSIESALQGDERCVLDTMRLVDL-------- 326

  Fly  1373 YELTCLIGELMPRLP---------LDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDS 1428
              |..|:.|....||         :.|:..:||        :.::.|.|..|...|....:.||:
Human   327 --LLVLLFEGRKALPKSSAGSTGRIPGLRRLDS--------SGERSHRQLIDCIRSKDTDALIDA 381

  Fly  1429 RLIEAANQSSEDEIS------LSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVA----PM 1483
            ....|...:..|::.      .|.||....|:|...:..:.:.|     ||..:.:|.|    |.
Human   382 IDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRG-----QRSSSLHYAACFGRPQ 441

  Fly  1484 --------SAGQDLT----TTSAGSAAAGGASTSAAAAAASSNNNNNNNNNPPGN---SVNLNQV 1533
                    .|..||.    .|....|...|.|...|...:            ||:   .||....
Human   442 VAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQS------------PGDWMCPVNKGDD 494

  Fly  1534 KRRPSLDARIACLKEERG---LAADFIKHIFNVLYEVYSSSAGPNVRYKCLRALLRMVYYATPEL 1595
            |::...:.......|.:|   :|..::|.:..|..:.:..:..|::|...|..:.:|:::.:..|
Human   495 KKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSIRKASLALIRKMIHFCSEAL 559

  Fly  1596 LRQVLKYQL----------VSSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGVIY 1650
            |::|....:          :::.:......:|..::  |||:...|:.:..|:|.....|.|||.
Human   560 LKEVCDSDVGHNLPTILVEITATVLDQEDDDDGHLL--ALQIIRDLVDKGGDIFLDQLARLGVIS 622

  Fly  1651 QFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAP-------------------ASANSLQV 1696
            :.:.|..|::........|| .....|..:|...|...                   :.|.:|::
Human   623 KVSTLAGPSSDDENEEESKP-EKEDEPQEDAKELQQGKPYHWRDWSIIRGRDCLYIWSDAAALEL 686

  Fly  1697 N-------PFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSG--ALDATS-S 1751
            :       .|.:|.......:|.:|......|.|...|...:.......|.:.|.  .|.|.. :
Human   687 SNGSNGWFRFILDGKLATMYSSGSPEGGSDSSESRSEFLEKLQRARGQVKPSTSSQPILSAPGPT 751

  Fly  1752 STTAGGYNYS-----SSAPSSSSG---------APAAYFVTQQGDPRQYVHFQQPAVPAPPPQQE 1802
            ..|.|.::.:     ..|..:|.|         .|...|.:.:|....:.           .:..
Human   752 KLTVGNWSLTCLKEGEIAIHNSDGQQATILKEDLPGFVFESNRGTKHSFT-----------AETS 805

  Fly  1803 L---------------LPSGVQQQGQQVPQV---IYQPHHQQPAHL---VLASTSSGAASSSSSS 1846
            |               |.|.:::..|:|..:   :|..|.:....:   |:.:..:.|....||.
Human   806 LGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDLYDDHFKAVESMPRGVVVTLRNIATQLESSW 870

  Fly  1847 SSSSSASALQHKMT--DMLK-------------RKAPPKRKSQSG-------------------- 1876
            ...::...::.:.|  |::|             ....|.....||                    
Human   871 ELHTNRQCIESENTWRDLMKTALENLIVLLKDENTISPYEMCSSGLVQALLTVLNNSMDLDMKQD 935

  Fly  1877 -----------GRAKSRQEDAAVAPA-------------------------GS------------ 1893
                       ..|.|..||....||                         ||            
Human   936 CSQLVERINVFKTAFSENEDDESRPAVALIRKLIAVLESIERLPLHLYDTPGSTYNLQILTRRLR 1000

  Fly  1894 -----GPGGA------------PPSSSGSAMHELLSRATS----------------LGSG----- 1920
                 .||..            .|.::..::.:.|.:..:                |..|     
Human  1001 FRLERAPGETALIDRTGRMLKMEPLATVESLEQYLLKMVAKQWYDFDRSSFVFVRKLREGQNFIF 1065

  Fly  1921 --------NG------------------------------GRSTPNSGGGSGSSKSRFNAGNSSN 1947
                    ||                              ||:.|.  |......||.|:..:.:
Human  1066 RHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGLVVVTSSEGRNLPY--GRLEDILSRDNSALNCH 1128

  Fly  1948 AGSSKSSFLA------------SLNPAR-WGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSG 1999
            :...|:::.|            :|..|| :||...:|....          :|||..|..|    
Human  1129 SNDDKNAWFAIDLGLWVIPSAYTLRHARGYGRSALRNWVFQ----------VSKDGQNWTS---- 1179

  Fly  2000 SGAGLAYT----VSQHGAGSGAG---------------------GLNAAAVAASISKS------- 2032
                 .||    .|.:..||.|.                     |.||:.....:|.|       
Human  1180 -----LYTHVDDCSLNEPGSTATWPLDPPKDEKQGWRHVRIKQMGKNASGQTHYLSLSGFELYGT 1239

  Fly  2033 --------ISHANLLAAANRERARQWVREQAVDFVK-----------RYTEQE------------ 2066
                    :..|...|.||..|.|:.||.|.:.::.           ::.:|:            
Human  1240 VNGVCEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVTGE 1304

  Fly  2067 ----------------------------------------AKRSKAASESGATQSGSS------- 2084
                                                    :.:..:::.||.|||.||       
Human  1305 LHNGWIDVTWDAGGSNSYRMGAEGKFDLKLAPGYDPDTVASPKPVSSTVSGTTQSWSSLVKNNCP 1369

  Fly  2085 -----GVGLSS---TGNTPLSTAGSTNV------LERLSSILFK---LNGSYHDCLDALLELKTI 2132
                 ..|.||   :.::..|.|.|:::      .||.|.|:.:   ::|:  |..:.::.|.: 
Human  1370 DKTSAAAGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGA--DVHEPIVVLSS- 1431

  Fly  2133 LLESDISPFEVNHSGLIKAMLNYMTSETGL--VER----DARLRSFMHVFAGLPLE--------- 2182
              ..::...||..|.  .|..:.:|:|||.  .||    |:.:|:        |.|         
Human  1432 --AENVPQTEVGSSS--SASTSTLTAETGSENAERKLGPDSSVRT--------PGESSAISMGIV 1484

  Fly  2183 ----PLLQNVGQMPTIE-------------------------PIAFGAFVAKLNGCVT-QLEQFP 2217
                |.:.:|.::...|                         |::..|.|..|:...| .||.|.
Human  1485 SVSSPDVSSVSELTNKEAASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFV 1549

  Fly  2218 VKVHDFPAGPGGRSNQSALRFF---NTHQLKCNL-----------QRHPQCNNLRQWKGGTVKID 2268
            .:|.:. |.....:|.:..|..   ||:.|..|:           |..|...........|:...
Human  1550 RRVANI-ARTNATNNMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTS 1613

  Fly  2269 PLAMVQAIERYLVVRGYG--------------------------------------GIRADSDDD 2295
            .:.....:.....|...|                                      .:.|:.|||
Human  1614 SVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDD 1678

  Fly  2296 ---------SEEDMDDN------VAAVVLSQASFRHKL--QFTIGDHVLPYNMTVYQAVKQFSPL 2343
                     .:|:.|||      ...::|.:.|.:.:.  :..:..|.:...:....|.....| 
Human  1679 EDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPAGAGSRP- 1742

  Fly  2344 VSEQPETDNESETLLGNASIW-------------------------VQQ---------HTIHYRP 2374
            :.||.|  .|.||..|....|                         |||         .|.|...
Human  1743 IGEQEE--EEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSEL 1805

  Fly  2375 VEE-EVTSG-------AAAGAASSSS----------------------SCSSGVQKQ-------- 2401
            :|| |.|..       ...|..::..                      ||:..|:..        
Human  1806 LEEVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEP 1870

  Fly  2402 ------QSSSSSASSCVNATSSCSSSSGVASGGGS-----------LTKKAHKS---------SS 2440
                  :....|.....|....|.|...|....|:           |.|.|..:         ::
Human  1871 TYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTN 1935

  Fly  2441 KFMRKKTELWHEGIAPVVISALKPFLSSSLPAD-----VVTVQDASL------------------ 2482
            |.:||...      ...:|:|.|.|......:.     :.|:|.:.:                  
Human  1936 KSIRKNRN------CSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLTKEQPQAKAGNGQNS 1994

  Fly  2483 ----DALCMLRVIHALNRHWDHLYGCVVRQN-------IIPQSDFIHPKIMAKANRQLQDPLVIM 2536
                |.|.:||:::.:.   ...|..:.:::       ..|..:|...||..|..:|:::||.:.
Human  1995 CGVEDVLQLLRILYIVA---SDPYSRISQEDGDEQPQFTFPPDEFTSKKITTKILQQIEEPLALA 2056

  Fly  2537 TGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLD----------TTPDLNAAESS 2591
            :|.||.|..|:...||||.|||||.|.|..|:|...||:..|.:          ||..:...:..
Human  2057 SGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPG 2121

  Fly  2592 ERVAPRLDRRKRAISRTE-ILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQ 2655
            |....||...:..:.|.| :::.||:::|.....|::||:::..|.||||||||||||||:||.|
Human  2122 EFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYALVAAEFQ 2186

  Fly  2656 RTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTT 2720
            |||||.|...|::..:....||:                                          
Human  2187 RTDLGAWLCDDNFPDDESRHVDL------------------------------------------ 2209

  Fly  2721 AQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSS 2785
                                |.|.:|..:                                    
Human  2210 --------------------GGGLKPPGY------------------------------------ 2218

  Fly  2786 TTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGK-SSKLPQMTKAKAKFKFLGKFMA 2849
                                       ||....|||..|..: |.:|.::||.   |.|||.|:|
Human  2219 ---------------------------YVQRSCGLFTAPFPQDSDELERITKL---FHFLGIFLA 2253

  Fly  2850 KAVMDSRMLDLPFSLPFYRWL--------------------------------VSEEH---SIG- 2878
            |.:.|:|::|||.|.||::.:                                ..|.|   |:| 
Human  2254 KCIQDNRLVDLPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGS 2318

  Fly  2879 ---------------------------LADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAME 2916
                                       ..|...|.|.....|..::||..:|..|||:..:...|
Human  2319 FEEDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDE 2383

  Fly  2917 KTEKIEQLDL-----DGCP--IADLGLDFV------LPGHANIELCRGGRDTPVTVHNLHQYISL 2968
            |..|:::|.|     .|.|  |.||||:|.      :.|...::|...|.|..:|:.|..:|:.|
Human  2384 KNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDL 2448

  Fly  2969 VTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRT 3033
            :..:.:..|:|||.||.|:||:.|||:::|..|..||::.:.||:    |...|..:.:......
Human  2449 MFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN----QSPSWAAEDIINYTEP 2509

  Fly  3034 DHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPN 3098
            ..|:.:||........:|...:.||::|||||.||...||.||...|.|.||:|||.   :....
Human  2510 KLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKV---DATDA 2571

  Fly  3099 DYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            .| |||.|||:|||||:|||.|:||::|..|..|  ..|||:
Human  2572 SY-PSVNTCVHYLKLPEYSSEEIMRERLLAATME--KGFHLN 2610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_649496.3 Extensin_2 <688..731 CDD:252669
SRP1 1087..>1312 CDD:227396 55/251 (22%)
WWE 1409..1481 CDD:128922 17/77 (22%)
HECTc <2818..3138 CDD:474882 123/396 (31%)
HECTD1NP_056197.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..269 3/22 (14%)
ANKYR <366..>479 CDD:440430 25/117 (21%)
ANK repeat 366..393 CDD:293786 5/26 (19%)
ANK 1 395..424 5/28 (18%)
ANK repeat 396..426 CDD:293786 6/34 (18%)
ANK 2 426..455 6/28 (21%)
ANK repeat 428..457 CDD:293786 6/28 (21%)
ANK 3 459..491 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513 4/23 (17%)
ANK 4 579..612 6/34 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748 8/40 (20%)
Sad1_UNC 1107..1240 CDD:400199 30/153 (20%)
MIB_HERC2 1277..1335 CDD:461991 1/57 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1406 13/62 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1483 14/59 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1515 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1757 18/85 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 3/19 (16%)
BTHB_HectD1 1893..1958 CDD:439138 14/70 (20%)
K-box 2029..2103 29/73 (40%)
HECTc 2131..2608 CDD:238033 163/614 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318 3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

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