DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Magi3

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_620784.3	Gene:	Magi3 / 245903	RGDID:	621362	Length:	1470	Species:	Rattus norvegicus

Alignment Length:	619	Identity:	106/619 - (17%)
Similarity:	194/619 - (31%)	Gaps:	201/619 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SVKSQSLSALTEGQHD-------DGGSTATSATLANK-----TSGTNTTSASNHSSQRRRNNNTN 56
            :|..||:..|:   ||       |.|.|.|...:|.:     .||||:...| .:.|.|......
  Rat   906 AVNGQSIVDLS---HDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQS-PALQHRPMGQAQ 966

  Fly    57 SNRNKSHHKNEKRNAPATSGPAVSSSVD---------VVPATSTASATSTRRSRSQGRHSSAAAL 112
            :    :|...::.......|..|.||..         ..|.|:..|...:|.|:|.|.:
  Rat   967 A----THIPGDRTALEGEVGKDVCSSYRHSWSDHKHLAQPDTAVISVVGSRHSQSLGCY------ 1021

  Fly   113 SSKESQIPKRSVGAIRSPSSPAFN------------------SIPVVSDQSLSPGSRKRQLN--- 156
                      .|...|.|....|:                  ..|.:.|..:..|.:..::|
  Rat  1022 ----------PVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1076

  Fly   157 QHNNSNNKASSSHQSAPGGDQ--LVCAPLKKRRLQQSLGSGICEGAVEINLGAASFDHTPRQASG 219
            ....::.:|....|:  ||::  |:..|          |:|:..            ||      |
  Rat  1077 TQGITHTRAIELIQA--GGNKVLLLLRP----------GTGLIP------------DH------G 1111

  Fly   220 DCVAQRTRSKTI----SPEELPSTSSAAAARHHQIRPSASSTSFSSSHRNKRKASIGGSIAAVET 280
            |.......|..:    .|..|||:.|||              :|..||           :...|.
  Rat  1112 DWDIYSPSSSNVIYDEQPPPLPSSHSAA--------------TFEESH-----------VPVTED 1151

  Fly   281 TPHRGTAAARAGRSGNLLNYYRKTRKVSHTRSSQKSEKQSIPAEDTT-----ANRNGSAGSGSSS 340
            :..|.....:|....:.:...:.|...|......:|.::::..:|.:     .::|...|....:
  Rat  1152 SLIRVQTCEKAEELKDTVQEKKSTLNGSQPEMKYQSVQKNVSKKDPSRSHGHGDKNLPKGENGVT 1216

  Fly   341 KSGVIPKNRKSL-RHSQQNLLDTEAAEVESAAAETGGEQQSEHGNLDVIDQLPTP---------- 394
            :.|.....:||: |||:::|                             :::|.|
  Rat  1217 RRGRSASPKKSVNRHSEEHL-----------------------------EKIPRPLRSDPKGKSR 1252

  Fly   395 --EAGPNQSEASGIHNQSQLEADRQPVVQDEDDEEDDEEEEEEEEEEVGFYGIVNSAGSSYEEDT 457
              ...|.:.|..|   |..::|...   ||...::........:::::|...:.|:.|...|..:
  Rat  1253 DRSLSPRKGENKG---QVTIKAGSG---QDPCRKDRGRSSSPRKQQKIGGNSLSNTEGKLSEAGS 1311

  Fly   458 QIVAEEDEITTEEEVDDEDDDEIEEEDLSESEFAQQLIGELGGERQQPQRATNNAKKTKNNTPAV 522
            :..|.....:.|:..:.::...:..:||..|:..:                 |..:..:..:..|
  Rat  1312 RRAAGLSSDSPEQLPEGKEKSGVSRKDLKLSQLGK-----------------NRTRSPEKRSSKV 1359

  Fly   523 AAASTIKATTTATTSSGYQQRAAPHGQGAAPGAG 556
            ..||.....|:.|.|....::.    :|..||.|
  Rat  1360 DEASLPSKKTSDTASRVVSEKE----KGRKPGTG 1389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Magi3	NP_620784.3	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:16316992	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:418433
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266
		HUL4	<211..>373	CDD:227354
		WW	299..329	CDD:238122
		WW	345..375	CDD:238122
		Interaction with PTEN. /evidence=ECO:0000250	413..495
		PDZ	416..496	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..575
		PDZ	578..659	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700
		PDZ	729..812	CDD:214570
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..847
		PDZ_signaling	851..936	CDD:238492	10/32 (31%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		11/35 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		8/41 (20%)
		PDZ_signaling	1023..1101	CDD:238492	13/79 (16%)
		PTZ00112	1115..>1405	CDD:240274	56/356 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1146		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1470		42/279 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900