DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Plekha7

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_017177675.1	Gene:	Plekha7 / 233765	MGIID:	2445094	Length:	1359	Species:	Mus musculus

Alignment Length:	1489	Identity:	263/1489 - (17%)
Similarity:	441/1489 - (29%)	Gaps:	540/1489 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 DQLVCAPLKKRRLQQSLGSGIC----------EGAVEINLGAASF-DHTPRQASGDCVAQRTRSK 229
            |||.|......|..:.:.||..          ||..|  .||:.| ||.          |:|
Mouse    29 DQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTE--EGASFFIDHN----------QQT--- 78

  Fly   230 TISPEELPSTSSAAAARHHQIRPSASSTSFSSSHRNKRKASIGGSIAAVETTPHRGTAAARAG-- 292
              :....|.|...::.....:.........|...||:|.:|:....:...||   .|..|:.|
Mouse    79 --TTFRHPVTGQFSSENSEYVLREEPHPHMSKPERNQRPSSMVSETSTAGTT---STLEAKPGPK 138

  Fly   293 --RSGNLLNYYRKTRKVSHTRSSQKSEKQSIPA--------EDTTANR----------------- 330
              :|.:.::.:.|       |........::|.        :|::..|
Mouse   139 IVKSSSKVHSFGK-------RDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYY 196

  Fly   331 --------NGSAGSGSSSKSGVIPKNRKSLRHSQQNLLDTEAAEVESAAAETGGEQQSEHG---- 383
                    .||....|...|.|.|::|.|.::|.:.:.....|.:.|..  |.|.|....|
Mouse   197 KDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTT--TAGSQMEHSGMRTY 259

  Fly   384 --NLDVIDQLPTPEAGPNQS-----------EASGIHNQSQLEADRQPVVQD------------- 422
              :.|.::.:.......||:           :...:..|:..:|:.....|:
Mouse   260 YFSADTLEDMNAWVRAMNQAAQVLSRSSLRRDVDKVERQAMPQANHTDACQECGHVGPGHSRDCP 324

  Fly   423 ----EDDEEDDEEEEEEEEEEVGFYGIVNSAGSSYEEDTQIVAEEDEITTEEEVDDEDDDEIEEE 483
                ||....:..|:|||........:......|......:.||||.:..:
Mouse   325 RRGYEDSYGFNRREQEEERFRAQRDPLEGRRDRSKARSPYLPAEEDALFVD-------------- 375

  Fly   484 DLSESEFAQQLIGELGGERQQPQRATNNAKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAP-- 546
                      |.|...|::.|||||      .||..|......       ...::|||:.|.|
Mouse   376 ----------LPGGPRGQQAQPQRA------EKNGVPPYGLGE-------QNGTNGYQRTAPPRA 417

  Fly   547 ----------------HGQGAAPGAGGGGP---RATRSSNSNSSNNVVDYSIMP----HLTTVAT 588
                            |...|..|.|...|   ...|...|...:...:|..:|    ||:..::
Mouse   418 NPEKHSQRKTGLAQAEHWTKAQKGDGRSLPLDQTLPRQGPSQPLSFPENYQSLPKSTRHLSGSSS 482

  Fly   589 TTPHAL-TPQQHQQQRQPPQPPSHQQQQVH-----------QQQQPPQLLPTHQFAHLSSFVTPT 641
            ..|..| :..::.|.|......|.::::.|           ||:|        ||.|.|    ||
Mouse   483 PPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQ--------QFRHGS----PT 535

  Fly   642 AAAAAAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHF 706
            |            |..|.:..|.:|...:          ...:.|:      |::|  .|.|...
Mouse   536 A------------PIGAGSPEFTEQGRSR----------SLLEVPR------SISV--PPSPSDI 570

  Fly   707 TSTGAGPPPALFQQQAPPQLTRYTPATATTAATFVPPQQQQVV-----YNPQQQQHSSLRRSSR- 765
            ...|   ||..|..:.|     :|||...|..   ||:|::.|     .:|::.:..:.:.||.
Mouse   571 PPPG---PPRPFPPRRP-----HTPAERVTVK---PPEQRRSVDISLGGSPRKARGHAAKNSSHV 624

  Fly   766 --------GKTGSCVSSAAAAQQQQHH------QQQQHSSAAAAVQQ----QLL---------PP 803
                    |.....||:.:...:....      :.|:|.|..|:|:.    |||         ..
Mouse   625 DRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLQRHQSKLASVRNFAVGQLLHHYLTFPACQA 689

  Fly   804 PGTY-------QY--QQVGGNTVVVAVRHQ----------------------------------- 824
            ..||       :|  .::..|..::.|.::
Mouse   690 DDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPGRSMTGRDLLKDRSLKPMKIAESD 754

  Fly   825 ---------------QQLQ------QQQQQQQQLALHHQHQQQQHQQQQQQH------QQQQHQ- 861
                           |.|:      ::.:.|.:..|...|:|.:..:.|.||      ||:..|
Mouse   755 IDVKLSIFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQE 819

  Fly   862 ------------------------------QQQRATLVQP---GFLFSYRSNQPQQQQQPAQQIH 893
                                          :|.:.||.:.   .|.|..:| |.|:.....:.:.
Mouse   820 DLVHIRAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKS-QIQKDLWRIEDVM 883

  Fly   894 QG-----------------------PKVTHSSAASDALTYSLMAQQ--PPSGP------------ 921
            .|                       |...|.|..|.:.|.|..|.|  ||:.|
Mouse   884 AGLSANKENYRVLVGSVKNPERKTVPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQ 948

  Fly   922 --------PHAGGQQITPGANSANLSIVAAALSAARDVGGGSDGGG-------------SAGGAT 965
                    ||           ...|..|.:.|.:.......::...             ....|.
Mouse   949 LQTYVPYRPH-----------PPQLRKVMSPLQSPTKAKPQAEDEAPPRPPLPELYSPEDQPPAV 1002

  Fly   966 PATGASASSVGNTSAVGASSSSNS-----SAGQAASSN---------SNNVTATGSGSAPGGGPT 1016
            |.....|:.:.:||..|....|:.     ..||..:.:         |....|:.||..|....:
Mouse  1003 PPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPELASLSGDVPQPSLS 1067

  Fly  1017 STGTTSGTQHGSGSGAAAAVDSESDDSEVGRLQALLEARGLPPHLFGALGPRVTHILHRTI-GNS 1080
            ..|:.|..|...|.|.:.:.......|.:.....|  .|||......|...|....|.|.. |:.
Mouse  1068 LVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTL--RRGLNAENSSATFSRPKSALERLYSGDH 1130

  Fly  1081 SSSK--ANQLLQGLQSHDESQQLQAAIEMCQMLVMGNEDT--LAGFPIKQVVPALIQLLRMEHNF 1141
            ...|  |.:.|:.::.|.     :|.:...:..:...|.|  |:...:.|.:|..:...:.|..|
Mouse  1131 QRGKMSAEEQLERMKRHQ-----KALVRERKRTLSQGEKTGLLSARYLSQPLPGDLGSWKREQEF 1190

  Fly  1142 D--IMNNACRALAYMLEALPRSSGTV-VEAVPVF----------------LEKLQVI----QCMD 1183
            |  ::..|.:.     :...:..|.: |:|.||.                |.|.:.:    :.::
Mouse  1191 DLQLLERAAQG-----DRKDKEEGWLKVQATPVMELDLEPQDYDLDISRELSKPEKVSIPERYVE 1250

  Fly  1184 VAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFVAE 1248
            :..:...:||.|..|:.|                     |::....:|.:...|:.|     :.:
Mouse  1251 LDPEEPPSLEELQARYQK---------------------AEKIRNILARSSMCNLQP-----LGQ 1289

  Fly  1249 SLPLLARLLSQ-QDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTP 1306
            ....||.|.|| |:::.|.::..|..      ....:|.:|:|       .|||.|:.|
Mouse  1290 DRNSLADLDSQLQEQERIINISYALA------SEASKRSKQVA-------VQQLALLPP 1335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	9/42 (21%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Plekha7	XP_017177675.1	WW	10..39	CDD:366073	4/9 (44%)
		WW	55..84	CDD:366073	10/45 (22%)
		PH_PEPP1_2_3	158..280	CDD:270068	21/123 (17%)
		Smc	<692..>894	CDD:224117	26/202 (13%)
		PHA03247	<903..1009	CDD:223021	18/116 (16%)
		PRK10263	<912..>1118	CDD:236669	40/218 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900