DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and NEDD4L

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_006722489.1	Gene:	NEDD4L / 23327	HGNCID:	7728	Length:	1019	Species:	Homo sapiens

Alignment Length:	1206	Identity:	234/1206 - (19%)
Similarity:	376/1206 - (31%)	Gaps:	468/1206 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  2125 ALLELKTILLESDISP-------FEVNHS--------------------GLIKAMLNYMTSETGL 2162
            ||::.|||  :..::|       |.||.|                    |.:...|:::.:|...
Human    85 ALVQTKTI--KKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT 147

  Fly  2163 VER-----DARLRSFMHV-----FAGLPLEPLLQNVGQ----MPTIEPIAFGAFVAKLNGCVTQ- 2212
            :||     |..||...|.     |..|.:..:.:|.||    ....:.:..|..|...|...:|
Human   148 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQH 212

  Fly  2213 LEQFPVKVHDFPAGPGGRSNQSAL--RFFNTHQLKCNLQRHPQC--------NNLRQWKGGTVKI 2267
            .|:.|..    |..||.......|  .::..|..:......|..        ||:||
Human   213 QEELPPP----PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQ-------- 265

  Fly  2268 DPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDD--------------NVAAVVLSQA------ 2312
                    |.:....|.:...|..|:|...|..:.              |:|...|..|
Human   266 --------INQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPA 322

  Fly  2313 -------------SFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPE--------TDNESE- 2355
                         ....:||.|...:           .:|||.|:..:|.        ||..:|
Human   323 SPGSRTSPQELSEELSRRLQITPDSN-----------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 376

  Fly  2356 --------------------------------TLLGNASIWVQQH---------------TIHYR 2373
                                            |..|..|.|.::.               |...|
Human   377 GHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTR 441

  Fly  2374 PVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASG-GGSLT----- 2432
            |:.:....||:..|.:|::.......::..|.||.:..::|....:..|.|... ..:|:
Human   442 PIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP 506

  Fly  2433 --------KKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLR 2489
                    |..||.:..|:...   |...|||    ..:||.... .....|.:|..|.....:|
Human   507 QPSPYNSPKPQHKVTQSFLPPG---WEMRIAP----NGRPFFIDH-NTKTTTWEDPRLKFPVHMR 563

  Fly  2490 VIHALNRH--------WD---HLYGCV---------------VRQNIIPQSDFIHPKIMAKANRQ 2528
            ...:||.:        |:   ||.|..               .|:: :|..|   .||....:.:
Human   564 SKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRES-VPSYD---SKITQWEDPR 624

  Fly  2529 LQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSER 2593
            ||:|.:            .|.|.|:...|:.::..|       .:.|::..|.............
Human   625 LQNPAI------------TGPAVPYSREFKQKYDYF-------RKKLKKPADIPNRFEMKLHRNN 670

  Fly  2594 VAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTL-EFYALVSAELQRT 2657
            :.....||..::.|.::|             ||.|.|::|:|.|...|... |::.|:|.|:...
Human   671 IFEESYRRIMSVKRPDVL-------------KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNP 722

  Fly  2658 DLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQ 2722
            ..||:                              |.:.||..|
Human   723 YYGLF------------------------------EYSATDNYT--------------------- 736

  Fly  2723 QHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTT 2787
                                    ::.:.:|...||:.|
Human   737 ------------------------LQINPNSGLCNEDHL-------------------------- 751

  Fly  2788 TATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAV 2852
                                    ||                           |.|:|:....||
Human   752 ------------------------SY---------------------------FTFIGRVAGLAV 765

  Fly  2853 MDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYIL-SDPNIDAME 2916
            ...::||..|..|||:.::.::  |.|.|:..|..|..|:|          ::|| :||.
Human   766 FHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSEYYNSL----------KWILENDPT----- 813

  Fly  2917 KTEKIEQLDLDGCPIADLGLDFVLPGHA-NIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQK 2980
                  :|||..|      :|....|.. .::|...|.:..||..|..:||.||..|..:..|||
Human   814 ------ELDLMFC------IDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQK 866

  Fly  2981 QFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSE-----QQHSRWEIKMLQESCRTDHGFHQD 3040
            |..|..|||..:.||..:::|...|||.:.||.|..     :|||.::           :|:..:
Human   867 QMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----------NGYCPN 920

  Fly  3041 SQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL----TPPLTIVRKTLDENQNPNDYL 3101
            ...||:.::.:...:.:::...||||||:.|:|..||..|    .|.|.    |:::..:| :.|
Human   921 HPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLF----TIEQWGSP-EKL 980

  Fly  3102 PSVMTCVNYLKLPDYSSREVMRQKLKVAANEGSMSF 3137
            |...||.|.|.||.|.:.|.:|:||.:|. |.:..|
Human   981 PRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	92/331 (28%)
NEDD4L	XP_006722489.1	C2_NEDD4_NEDD4L	21..179	CDD:175999	21/95 (22%)
		WW	224..250	CDD:278809	3/25 (12%)
		WW	413..442	CDD:278809	3/28 (11%)
		WW	526..556	CDD:238122	8/37 (22%)
		WW	575..625	CDD:197736	9/53 (17%)
		HECTc	662..1016	CDD:238033	120/565 (21%)
		HECTc	686..1015	CDD:214523	116/539 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900