DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and WWC1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_011532787.1	Gene:	WWC1 / 23286	HGNCID:	29435	Length:	1185	Species:	Homo sapiens

Alignment Length:	1367	Identity:	262/1367 - (19%)
Similarity:	434/1367 - (31%)	Gaps:	482/1367 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1775 YFV------TQQGDPR------------QYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQ 1821
            ||:      ||..|||            .|:...|.|:.|   |:|:..  |:||..::.|..||
Human    70 YFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSA---QKEIYQ--VKQQRLELAQQEYQ 129

  Fly  1822 PHHQQPAHLVLASTSSGAASSSSS-----------SSSSSSASALQHKMTDMLKRKAPPKRKSQS 1875
            ..|....|.:.:..|..:.|||||           :::.|..:.|:.:|..:.......:|..|:
Human   130 QLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQT 194

  Fly  1876 GGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHE--LLSRATSLGSGNGGRSTPNSGGGSGSSKS 1938
            ..:...:..||        .|......:.:.:.|  .:.:|.:.|.
Human   195 LKKIDKKMSDA--------QGSYKLDEAQAVLRETKAIKKAITCGE------------------- 232

  Fly  1939 RFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAG 2003
                       ..|...:.||...:.|.:|.:..|              .|..:|:|:...|...
Human   233 -----------KEKQDLIKSLAMLKDGFRTDRGSH--------------SDLWSSSSSLESSSFP 272

  Fly  2004 LA---YTVSQHGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQ 2065
            |.   ..||.....||:.|:|:             .|.||...|.|.|.               :
Human   273 LPKQYLDVSSQTDISGSFGINS-------------NNQLAEKVRLRLRY---------------E 309

  Fly  2066 EAKRSKAASESGATQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLN------GSYHDCLD 2124
            ||||..:.....||.|.|.    .:....|.:::.:...|...|..||.|.      ||...|.:
Human   310 EAKRRLSCQCGQATPSNSE----LTHYQLPQASSKTARHLYLDSHFLFSLKRTTLNLGSVPSCRN 370

  Fly  2125 AL------LELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEP 2183
            |.      |:::...|:|:..|      |::.:            ||| ||.....      .|.
Human   371 ACLRWIANLKIQLAKLDSEAWP------GVLDS------------ERD-RLILINE------KEE 410

  Fly  2184 LLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVH-DFPAGPGGRSNQS-ALRFFNTHQLKC 2246
            ||:   :|..|.|..:      ..|.|.|||....::. |..|   .|..|| ||    |.:||.
Human   411 LLK---EMRFISPRKW------TQGEVEQLEMARKRLEKDLQA---ARDTQSKAL----TERLKL 459

  Fly  2247 NLQR-----------------HPQC----------------NNLRQWKGGTVK------------ 2266
            |.:|                 |.|.                .:|...:|..|.
Human   460 NSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFT 524

  Fly  2267 ---IDPL----AMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGD 2324
               .||.    :.:|:...:|::.|..|.|......:..  :|.||....::...|  ||.....
Human   525 DLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIH--EDEVAKTQKAEGGGR--LQALRSL 585

  Fly  2325 HVLPYNMTVYQAVKQFS------------PLVS----------EQPETDNESETL----LGNASI 2363
            ...|.:||........|            ||::          |.||.   |.||    |||::
Human   586 SGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLNSLEFEDPEL---SATLCELSLGNSA- 646

  Fly  2364 WVQQHTIHYRPVEEEVTSGAAAG-AASSSSSCSSGVQKQQSSSSSASSCVNAT---SSCSSSSGV 2424
              |:   .|| :||..|.|...| |.:::..|...|           :||:|.   .|.:..|||
Human   647 --QE---RYR-LEEPGTEGKQLGQAVNTAQGCGLKV-----------ACVSAAVSDESVAGDSGV 694

  Fly  2425 ASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDAL---- 2485
            ..  .|:.:.....::.|...::|.  .|...:.| ||| :...:....::.:|.::|.||
Human   695 YE--ASVQRLGASEAAAFDSDESEA--VGATRIQI-ALK-YDEKNKQFAILIIQLSNLSALLQQQ 753

  Fly  2486 ------------------CMLR-----------------------VIHALNRHWD-------HLY 2502
                              |:.|                       .:|......|       ||.
Human   754 DQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLE 818

  Fly  2503 GCVVRQNI----IPQS--------DFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLF 2555
            .|:....|    :.:|        :.:..|.:.|.:|:|:               .:|:..|...
Human   819 ECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELK---------------PVGVMAPASG 868

  Fly  2556 PFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQAEHILQD 2620
            |..|       .|:|:| |:..||            |:.|..|::|:...|.|:.|:.:.. .::
Human   869 PAST-------VSWDQD-AVSALL------------EQTAVELEKRQEGRSSTQTLEDSWR-YEE 912

  Fly  2621 FGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAV 2685
            ...::|:.| :.|.||....|....|....|.::        :|..:.|.:..|..:....:..|
Human   913 TSENEAVAE-EEEEEVEEEEGEEDVFTEKASPDM--------DGYPALKVDKETNTETPAPSPTV 968

  Fly  2686 LHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQ--------------HQHPP-TRSSSRS 2735
            :..:|  ....|....|.:.|::::.|.|.:....:|.              .:.|| .|:|...
Human   969 VRPKD--RRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLER 1031

  Fly  2736 HVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTN 2800
            ..:|......|.:.||..:..:|..:...:..:           :|..::.|      .|:..|.
Human  1032 RSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLE-----------LDLQATRT------WHSQLTQ 1079

  Fly  2801 NSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLP 2865
            ..|::............||        ..:|||..:...:|:.|.:.:.|..||
Human  1080 EISVLKELKEQLEQAKSHG--------EKELPQWLREDERFRLLLRMLEKRQMD----------- 1125

  Fly  2866 FYRWLVSEEH--SIGLADLMRVA---------------PEVQNTLVRLQDLVRQREYILSDPNID 2913
                  ..||  .:....:||.|               ||||:...::....|.|      .||.
Human  1126 ------RAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPR------MNIP 1178

  Fly  2914 AM 2915
            |:
Human  1179 AL 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	21/91 (23%)
		HECTc	<2818..3138	CDD:294058	24/115 (21%)
WWC1	XP_011532787.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809	4/13 (31%)
		ALDH-SF	429..>481	CDD:299846	15/58 (26%)
		C2_Kibra	721..844	CDD:176062	17/124 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900