DRSC/TRiP Functional Genomics Resources

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Protein Alignment ctrip and HECW1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_016867371.1 Gene:HECW1 / 23072 HGNCID:22195 Length:1639 Species:Homo sapiens


Alignment Length:2022 Identity:394/2022 - (19%)
Similarity:643/2022 - (31%) Gaps:587/2022 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1306 PAILNTGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLYL-----LTGNAEPAAASATHVEL- 1364
            |.:.:.|  :.||:.:|........| ||.|...:|.|.||.     |...|.|:..|.:.... 
Human     7 PTVKDPG--SVVVQGVSKQVARSAFL-ISRLTPAVAITNLYQNRFLGLAAMASPSRNSQSRRRCK 68

  Fly  1365 ----ISRSPSELYELTCLIGELMPRLPLDGIFAVDSLLD--------RPTL----------NTQD 1407
                .|.:|.:.:.:....|      |.||:....|..|        |.||          ::||
Human    69 EPLRYSYNPDQFHNMDLRGG------PHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQD 127

  Fly  1408 QV-HWQWRD--DRGSWHNYSTIDSRLIE--------AANQSSEDEISLSTFGRTYTVD------- 1454
            .| ||..::  |.|.|.....||..|.|        ..|.|...:|.......:|.|:       
Human   128 LVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICF 192

  Fly  1455 --FHAMQQINEDTGTTRPVQRRLNHNYVAPM--SAGQDLTTTSAGSAAAGGASTSAAAAAASSNN 1515
              :|.:......|..:..|:     |..||:  |.|.|.|....||...  .|.|.:...|....
Human   193 KYYHGVSGALRATTPSVTVK-----NSAAPIFKSIGADETVQGQGSRRL--ISFSLSDFQAMGLK 250

  Fly  1516 NNNNNNNPPGNSVNLNQVKRR--PSLDARIACLKEERGLAADFIKHIFNVLYEVYSSSAGPNVRY 1578
            .....|..|...:::...|..  |:|...    .:||  .:..|.:..|.:::....|       
Human   251 KGMFFNPDPYLKISIQPGKHSIFPALPHH----GQER--RSKIIGNTVNPIWQAEQFS------- 302

  Fly  1579 KCLRALLRMVYYATP-ELLRQVLKYQLVSSH--IAGMLGSNDL-------RIVVGALQMAEILMR 1633
                      :.:.| ::|...:|.:...|.  |...||...:       |..:|...::..|.|
Human   303 ----------FVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGR 357

  Fly  1634 QLP--DVFG-THFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQ 1695
            :||  .|.| ..||     ::.|....|.:....:.|.:|.||..         |.:|  .|:| 
Human   358 RLPTDHVSGQLQFR-----FEITSSIHPADDEEISLSTEPESAQI---------QDSP--MNNL- 405

  Fly  1696 VNPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNY 1760
                 |:|..| ...|..|.||  :|:..:.....         ..|.|          .|..:.
Human   406 -----MESGSG-EPRSEAPESS--ESWKPEQLGEG---------SVPDG----------PGNQSI 443

  Fly  1761 SSSAPSSSSGAPAAYFVTQQGDP-----------RQYVHFQQPAVPAPPPQQ--ELLPSGVQ--- 1809
            ..|.|     |..|..:|:.||.           ......|:...|||..::  |.|..|.:   
Human   444 ELSRP-----AEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASA 503

  Fly  1810 ---QQGQQVPQVIYQPHHQQPAHLVLASTSS--GAASSSSSSSSSSSASALQHKMTDMLKRKAPP 1869
               :.|:.......:|..::      |:|.|  |..............|.|: :....|:.:|..
Human   504 LLLEDGEAPASTKEEPLEEE------ATTQSRAGREEEEKEQEEEGDVSTLE-QGEGRLQLRASV 561

  Fly  1870 KRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSG 1934
            ||||:......|..| ..:|.|...|  ..|.:....:|.||.   |:.|..||.:.....|...
Human   562 KRKSRPCSLPVSELE-TVIASACGDP--ETPRTHYIRIHTLLH---SMPSAQGGSAAEEEDGAEE 620

  Fly  1935 SSKSRFNAGNSSNAGSSKSSFLASLNPARWGRQ-----------THQNHHHHHQQSQQQHHGLSK 1988
            .|..:   .:|...|.|:...:|: :|:.....           .|..|...|..|..  :|.::
Human   621 ESTLK---DSSEKDGLSEVDTVAA-DPSALEEDREEPEGATPGTAHPGHSGGHFPSLA--NGAAQ 679

  Fly  1989 DSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASISKSISHANLLAAANRERARQWVRE 2053
            |.....||||.|.:.     .:.|......|.:|:..:.|...|..::.                
Human   680 DGDTHPSTGSESDSS-----PRQGGDHSCEGCDASCCSPSCYSSSCYST---------------- 723

  Fly  2054 QAVDFVKRYTEQEAKRSKAASESGATQSGSSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGS 2118
                        ....|...|.|..:.|..:|...:|  :|..|:..|..:.|   |.:|.....
Human   724 ------------SCYSSSCYSASCYSPSCYNGNRFAS--HTRFSSVDSAKISE---STVFSSQDD 771

  Fly  2119 YHDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGL--PL 2181
            ..:...|...:...:...::.|...|.:|   ...:.:.:.:|.|||...         ||  |:
Human   772 EEEENSAFESVPDSMQSPELDPESTNGAG---PWQDELAAPSGHVERSPE---------GLESPV 824

  Fly  2182 E----------PLLQN---VGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGRSNQ 2233
            .          |:|.|   |.|:|::.|               :...:|......|.....|.:.
Human   825 AGPSNRREGECPILHNSQPVSQLPSLRP---------------EHHHYPTIDEPLPPNWEARIDS 874

  Fly  2234 SALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEE 2298
            ....|:..|           .|....|:..|....|..|          |..|.|:.        
Human   875 HGRVFYVDH-----------VNRTTTWQRPTAAATPDGM----------RRSGSIQQ-------- 910

  Fly  2299 DMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASI 2363
                      :.|.:.|                  ||.:::  .:.:|:.|.|:.|::.      
Human   911 ----------MEQLNRR------------------YQNIQR--TIATERSEEDSGSQSC------ 939

  Fly  2364 WVQQHTIHYRPVEEEVTSGAAAGAASSS---SSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVA 2425
                         |:..:|...|..|.|   ||.||...:::.|.|..:|               
Human   940 -------------EQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNS--------------- 976

  Fly  2426 SGGGSLTKKAHKSSSKFMRKKT--ELWHEGIAPVVISALKPFLSSS-LPADVVTVQDASLDALCM 2487
               ..:|......:.||:....  .:.|..     .||.:.|.||: |...::.|:   .||...
Human   977 ---QKITLLLQSPAVKFITNPEFFTVLHAN-----YSAYRVFTSSTCLKHMILKVR---RDARNF 1030

  Fly  2488 LRVIH----------------ALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIM 2536
            .|..|                .|.|.|:      ::.:...:|.|:...  ::|...:...:.:.
Human  1031 ERYQHNRDLVNFINMFADTRLELPRGWE------IKTDQQGKSFFVDHN--SRATTFIDPRIPLQ 1087

  Fly  2537 TGNLPQWLPQIGMACPFLFPFETRHL-------LFYATSFDRDRALQRLLDTTPDLNAAESSE-- 2592
            .|.||..|.            ..:||       ...|:...|:|....|......|.||..|:  
Human  1088 NGRLPNHLT------------HRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQ 1140

  Fly  2593 -------------------RVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGT 2638
                               .:...|..|:.:::|...|::..|.::..|:.              
Human  1141 HESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNH-------------- 1191

  Fly  2639 GLGPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPA 2703
            ||            |....|..|......:::..::.|.:..|..............::.||:|.
Human  1192 GL------------EKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPG 1244

  Fly  2704 VAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRS--------GAGQQP--------VEHSSS 2752
            :..||..:.|              |.|....:. ||:        |.||.|        .:|   
Human  1245 LQRASARAPS--------------PYRRDFEAK-LRNFYRKLEAKGFGQGPGKIKLIIRRDH--- 1291

  Fly  2753 SAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSS-----IITTTTTTS 2812
               ..|...|.|:|....:..          .:....|.|.:.....:..|     :::......
Human  1292 ---LLEGTFNQVMAYSRKELQ----------RNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNP 1343

  Fly  2813 YVHAVHGLFPLPLGKSSKLPQMTKAKA-------KFKFLGKFMAKAVMDSRMLDLPFSLPFYRWL 2870
            |    :|||......:..: |::...|       .|:|.|:.:..|::...:||..|:.|||:.|
Human  1344 Y----YGLFEYSANDTYTV-QISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKAL 1403

  Fly  2871 VSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNI-DAMEKTEKIEQLDLDGCPIADL 2934
            :  .....|:||..:..|...:|           ..:.|.|| |.::.|..:.            
Human  1404 L--RLPCDLSDLEYLDEEFHQSL-----------QWMKDNNITDILDLTFTVN------------ 1443

  Fly  2935 GLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLR 2999
              :.|.......||..||.:|.||..|..:||..:..|.:..||.:|.|||..||..|...:.:.
Human  1444 --EEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVS 1506

  Fly  3000 MFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH--GFHQDSQAIQYLYEILASYNRDEQRAF 3062
            :|...|||.|..|:.        ||.:......|::  |:|.....|::.:..:..:|.:::...
Human  1507 VFDARELELVIAGTA--------EIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRL 1563

  Fly  3063 LQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLK 3127
            ||||||:..:|..||.||... ..:|:...|.......||...||.|.|.||.|.|..::.:||.
Human  1564 LQFVTGTSSVPYEGFAALRGS-NGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLL 1627

  Fly  3128 VAANEGS 3134
            .|..|.|
Human  1628 TAVEETS 1634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922 19/91 (21%)
FAM199X <1985..2074 CDD:292442 13/88 (15%)
HECTc <2818..3138 CDD:294058 88/327 (27%)
HECW1XP_016867371.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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