DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and Hectd2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001156943.1	Gene:	Hectd2 / 226098	MGIID:	2442663	Length:	775	Species:	Mus musculus

Alignment Length:	338	Identity:	92/338 - (27%)
Similarity:	152/338 - (44%)	Gaps:	58/338 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  2815 HAVHGLFPLPLGKSSKLPQMTKAK----AKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVS--- 2872
            |..:|:|  ...|.|.....:..|    ::|:.:|..|..||.:|..||:.|....|:.|:|
Mouse   473 HPDYGMF--TYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPV 535

  Fly  2873 ----EEHSIGLA-----DLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDA-MEKTEKIEQLDLD 2927
                :...:|:.     ||.:|.||:.:.|         :|.:..:.|::. ...|.::.|.:..
Mouse   536 VPSDQSTPVGICSVTIDDLCQVMPELAHGL---------KELLSYEGNVEEDFYSTFQVFQEEFG 591

  Fly  2928 GCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSV 2992
                       |:..:   .|..||...|||..|..:|:.|.|.:.|.:.:.|||.|...||.||
Mouse   592 -----------VIKSY---NLKPGGDKIPVTNQNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSV 642

  Fly  2993 FPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILASYNRD 3057
            .....|.:..|||:|.:.|||.....|:      ||.|.:.| |:.:....|:|.::::..:..:
Mouse   643 CASNALMLLRPEEVEILVCGSPELDMHA------LQRSTQYD-GYAKTDLTIRYFWDVVLGFPLE 700

  Fly  3058 EQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVM 3122
            .|:..|.|.|||.|:|.||...|       ...:.:|:...::||...||.|.|.||.|.|::.:
Mouse   701 LQKKLLHFTTGSDRVPVGGMADL-------NFKISKNETSTNWLPVAHTCFNQLCLPPYKSKKDL 758

  Fly  3123 RQKL--KVAANEG 3133
            :|||  .::.:||
Mouse   759 KQKLIIGISNSEG 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	91/335 (27%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		HECTc	416..773	CDD:238033	92/338 (27%)
		HECTc	439..772	CDD:214523	92/338 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900